Immune Regulation News Volume 13.29 | Aug 6 2021

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    2021-08-06 | IRN 13.29


    Immune Regulation News by STEMCELL Technologies
    Vol. 13.29 – 6 August, 2021
    TOP STORY

    The Microbiota Coordinates Diurnal Rhythms in Innate Immunity with the Circadian Clock

    Rhythmic segmented filamentous bacteria (SFB) attachment was driven by the circadian clock through control of feeding rhythms. Mechanistically, rhythmic SFB attachment activated an immunological circuit involving group 3 innate lymphoid cells.
    [Cell]

    AbstractGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Dual Targeting of CTLA-4 and CD47 on Treg Cells Promotes Immunity against Solid Tumors

    The authors found that anti–cytotoxic T lymphocyte–associated protein 4 (CTLA-4)×SIRPα preferentially depleted ICOShigh immunosuppressive Treg cells in the tumor microenvironment and enhanced immunity against solid tumors, including MC38 and CT26 murine colon cancers.
    [Science Translational Medicine]

    Abstract

    MAIT Cells Regulate NK Cell-Mediated Tumor Immunity

    Investigators showed that MR1-restricted mucosal-associated invariant T (MAIT) cell-deficient mice have enhanced NK cell-dependent control of metastatic B16F10 tumor growth relative to control mice.
    [Nature Communications]

    Full Article

    The Circular RNA circINPP4B Acts as a Sponge of miR-30a to Regulate Th17 Cell Differentiation during Progression of Experimental Autoimmune Encephalomyelitis

    Using transcriptome microarray analysis at different stages of experimental autoimmune encephalomyelitis (EAE), researchers identified the EAE progression-related circINPP4B, which showed upregulated expression in Th17 cells from mice with EAE and during Th17 differentiation in vitro.
    [Cellular & Molecular Immunology]

    Full Article

    IL-25–Induced Shifts in Macrophage Polarization Promote Development of Beige Fat and Improve Metabolic Homeostasis in Mice

    Scientists found that interleukin (IL)-25 signaling through its cognate receptor, IL-17 receptor B, increased in adipose tissue after cold exposure and β3-adrenoceptor agonist stimulation.
    [PLoS Biology]

    Full Article

    Driving Regeneration, Instead of Healing, in Adult Mammals: The Decisive Role of Resident Macrophages through Efferocytosis

    By using studies of gain and loss of function, specific cell depletion approaches, and hematopoietic chimeras researchers demonstrated that tissue regeneration in adult mammals depends on an early and transient peak of granulocyte producing reactive oxygen species and an efficient efferocytosis specifically by tissue-resident macrophages.
    [NPJ Regenerative Medicine]

    Full Article

    Tissue Signals Imprint Aiolos Expression in ILC2s to Modulate Type 2 Immunity

    The authors interrogated the signatures of group 2 innate lymphoid cells from five tissues at the transcriptome and epigenetic level.
    [Mucosal Immunology]

    Abstract

    mTOR Signaling Mediates ILC3-Driven Immunopathology

    Using mice specifically defective for either mTORC1 or mTORC2 in ILC3s, scientists show that both mTOR complexes regulate the maintenance of type III Innate lymphoid cells at steady state and pathological immune response during colitis.
    [Mucosal Immunology]

    Abstract

    Mechanism of TCONS_00147848 Regulating Apoptosis of Nasal Mucosa Cells and Alleviating Allergic Rhinitis through FOSL2-Mediated JAK/STAT3 Signaling Pathway

    Researchers explored the roles and related mechanisms of lncRNA-TCONS_00147848 in nasal mucosa cell apoptosis and allergic rhinitis (AR). AR mice were sensitized with ovalbumin, with the TCONS_00147848 interference lentiviral vector and FOSL2 overexpressing lentiviral vectors constructed respectively.
    [Scientific Reports]

    Full Article

    Mechanically Active Adhesive and Immune Regulative Dressings for Wound Closure

    Investigators developed a mechanically active adhesive and immune regulative dressin, mainly consisting of temperature-sensitive hydrogel with semi-interpenetrating network structure.
    [Matter]

    AbstractGraphical Abstract

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    REVIEWS

    Importance of Lymphocyte–Stromal Cell Interactions in Autoimmune and Inflammatory Rheumatic Diseases

    The authors describe the importance of lymphocyte-stromal cell interactions in chronic inflammation, with a focus on human disease, using three selected autoimmune and inflammatory diseases.
    [Nature Reviews Rheumatology]

    Abstract

    INDUSTRY AND POLICY NEWS

    BioMed X Institute Today Announces Two New Research Groups in Autoimmunity and Drug Delivery in Collaboration with Janssen

    German independent research institute BioMed X announced the start of two new research projects with Janssen Research & Development, LLC, one of the Janssen Pharmaceutical Companies of Johnson & Johnson. The new research group Protective Tissue Factors in Autoimmune Diseases is led by Dr. Mojca Frank Bertoncelj, whose research group will develop new approaches to combat chronic inflammatory diseases.
    [Revolo Biotherapeutics]

    Press Release

    Moderna Announces First Participant Dosed in Phase I Study of Its IL-2 mRNA Therapeutic

    Moderna, Inc. announced the first participant has been dosed in the Phase I study of mRNA-6231, the company’s mRNA-encoded IL-2 modified for the expansion of regulatory T cells.
    [Moderna, Inc.]

    Press Release
    FEATURED EVENT

    Translational Immunology

    November 22 – 23, 2021
    Ghent, Belgium

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    JOB OPPORTUNITIES

    Research Assistant – Pharmacology

    The Scripps Research Institute – La Jolla, California, United States

    Scientist – Autoimmune and Inflammatory Diseases

    Amgen – San Francisco, California, United States

    Postdoctoral Research Fellow – Inflammatory Bowel Disease

    Harvard Medical School​ – Boston, Massachusetts, United States

    Assistant Professor – Translational Metabolism

    Dalhousie University – Halifax, Nova Scotia, Canada

    Postdoctoral Scholar – Immunology, Cancer Immunotherapy, and Protein Engineering

    University of California Irvine – Irvine, California, United States

    > See All Jobs

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