 | | Vol. 13.30 – 13 August, 2021 |
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| The authors utilized an engineered microbial organism with a six-letter semi-synthetic DNA code to generate a library of site-specific, click chemistry compatible amino acid substitutions in the human cytokine IL-2.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that the differentiation of innate lymphoid cells (ILC2s), and their concomitant high level of GATA3 expression, were controlled by a Gata3 enhancer, Gata3 +674/762, that played only a minimal role in T helper type 2 cell differentiation.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers investigated the mechanism of how SLC15A4 directed inflammatory responses. Proximity-dependent biotin identification revealed glycolysis as highly enriched gene ontology terms.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists established two murine Ebf1-deficient pro-B cell lines, with and without T-lineage potential. The latter expressed lower levels of Lmo2; their potential was restored via ectopic expression of Lmo2.
[eLife] |
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| The authors demonstrated that hexavalent chromium inhibited the formation of neutrophil extracellular traps in rat peripheral blood and induced neutrophils apoptosis by inhibiting the AMP-activated protein kinase (AMPK) signaling pathway.
[Ecotoxicology and Environmental Safety] |
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| Investigators used protein engineering methods to develop new recombinant antibodies that detected the N-terminal leucine zipper structural domain of myocilin and that were cross-reactive for human and mouse myocilin.
[Journal of Biological Chemistry] |
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| Scientists investigated the effect of diesel exhaust particles (DEP) exposure on allergic rhinitis using a mouse model. BALB/c mice sensitized to house dust mite (HDM) were intranasally challenged with HDM in the presence and absence of DEP.
[Scientific Reports] |
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| To investigate the mechanism of cysteine protease cathepsin S (CTSS) in systemic lupus erythematosus (SLE), CTSS-overexpressing transgenic mice were generated, and induced lupus-like symptoms.
[Scientific Reports] |
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| Researchers evaluated the effects of the autophagy activator AZD8055 on experimental autoimmune encephalomyelitis (EAE). EAE model mice were established, histological examination was performed to assess the degree of inflammatory cell infiltration and demyelination.
[Biochemical and Biophysical Research Communications] |
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| The authors summarizes the recent preclinical and clinical progress on RORγ with emphasis on its role in reprogramming tumor cholesterol metabolism and its regulation.
[Biochemical Pharmacology] |
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| Investigators explore the role of cellular senescence in age-associated lymphoid organ dysfunction and immunosenescence, and provide a framework to explore therapies to rejuvenate the aged immune system.
[Aging-Us] |
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| VYNE Therapeutics, Inc. announced that it has entered into an exclusive license agreement with In4Derm Limited, a spin-out of the University of Dundee’s School of Life Sciences focused on the discovery and development of proprietary Bromodomain and Extra-Terminal Domain inhibitors (BET inhibitor) for the treatment of immunology and oncology conditions.
[VYNE Therapeutics, Inc.] |
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| Two University of Missouri (MU) School of Medicine researchers will receive $2.2 million of a $3 million grant from the US Department of Defense to test a potentially life-changing, novel treatment for millions of people with type 1 diabetes.
[The Missourian] |
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| September 26 – October 1, 2021
Orlando, Florida, United States |
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| | Purdue University – West Lafayette, Indiana, United States |
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| | University Of Wisconsin–Madison – Madison, Wisconsin, United States |
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| | National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States |
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| | NYU Langone Health – New York, New York, United States |
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| | Queen’s University Belfast – Belfast, Northern Ireland, United Kingdom |
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