Immune Regulation News Volume 13.31 | Aug 20 2021

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    2021-08-20 | IRN 13.31


    Immune Regulation News by STEMCELL Technologies
    Vol. 13.31 – 20 August, 2021
    TOP STORY

    GM-CSF Drives Myelopoiesis, Recruitment and Polarisation of Tumour-Associated Macrophages in Cholangiocarcinoma and Systemic Blockade Facilitates Antitumour Immunity

    Blood and tumors were analyzed from Intrahepatic cholangiocarcinomapatients (iCCA) and controls. Treatment and correlative studies were performed in mice with autochthonous and established orthotopic iCCA tumors treated with anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) monoclonal antibody.
    [Gut]

    Full Article
    As a scientist, how you separate the facts from the claims is just as important as how you separate your cells. See for yourself.
    PUBLICATIONSRanked by the impact factor of the journal

    Single-Cell Evaluation Reveals Shifts in the Tumor-Immune Niches That Shape and Maintain Aggressive Lesions in the Breast

    Single-cell transcriptomics and multiparametric imaging applied to a mouse model of breast cancer revealed that the aggressive tumor niche was characterized by an expanded basal-like population, specialization of tumor subpopulations, and mixed-lineage tumor cells potentially serving as a transition state between luminal and basal phenotypes.
    [Nature Communications]

    Full Article

    Tet2 Controls the Responses of β Cells to Inflammation in Autoimmune Diabetes

    Researchers showed that Tet2 regulated pathologic interactions between β cells and immune cells and controlled damaging inflammatory pathways.
    [Nature Communications]

    Full Article

    Stromal Cell-Derived DEL-1 Inhibits Tfh Cell Activation and Inflammatory Arthritis

    Scientists mice with endothelial-specific overexpression of DEL-1 were protected from arthritis relative to WT controls, while arthritis was exacerbated in DEL-1-deficient mice.
    [Journal of Clinical Investigation]

    AbstractGraphical Abstract

    Memory IgM Protects Endogenous Insulin from Autoimmune Destruction

    The authors immunized wild-type mice with insulin as a common self-antigen and monitored diabetes symptoms as a measure for autoimmune disease.
    [EMBO Journal]

    Full ArticleGraphical Abstract

    Experimental Colitis Promotes Sustained, Sex-Dependent, T-Cell-Associated Neuroinflammation and Parkinsonian Neuropathology

    In mouse models, investigators assessed whether dextran sodium sulfate-mediated colitis could exert lingering effects on dopaminergic pathways in the brain and whether colitis increased vulnerability to a subsequent exposure to the dopaminergic neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
    [Acta Neuropathologica Communications]

    Full ArticleGraphical Abstract

    Lenvatinib Enhances T Cell Immunity and the Efficacy of Adoptive Chimeric Antigen Receptor-Modified T Cells by Decreasing Myeloid-Derived Suppressor Cells in Cancer

    The antitumour activity of lenvatinib in immunocompetent and immunodeficient mice was compared to determine the role of T cell immunity. The antitumour activity of T cells was analyzed by cytokine production and adoptive T cell therapy.
    [Pharmacological Research]

    AbstractGraphical Abstract

    Development of an Immune-Related lncRNA–miRNA–mRNA Network Based on Competing Endogenous RNA in Periodontitis

    Researchers explored the relationship between lncRNAs and immune response and to construct an immune-related competing endogenous RNA network in periodontitis.
    [Journal of Clinical Periodontology]

    Abstract

    Lymph Node Stromal Cell–Intrinsic MHC Class II Expression Promotes MHC Class I–Restricted CD8 T Cell Lineage Conversion to Regulatory CD4 T Cells

    Scientists examined the cellular and molecular elements that promoted CD8-to-CD4 lineage conversion and the development of CI-Treg cells in mice.
    [Journal of Immunology]

    Abstract
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    REVIEWS

    Technological Advances in Cancer Immunity: From Immunogenomics to Single-Cell Analysis and Artificial Intelligence

    The authors summarize conventional and state-of-the-art technologies in the field of immunogenomics, single-cell and artificial intelligence, and present prospects for future research.
    [Signal Transduction and Targeted Therapy]

    Full Article

    Neutrophils in Secondary Lymphoid Organs

    Understanding the mechanisms underpinning the effects of neutrophils on lymph node immune cells and adaptive immunity could facilitate the development of neutrophil-targeted therapies in inflammatory diseases.
    [Immunology]

    AbstractFull Article
    INDUSTRY AND POLICY NEWS

    Cytocom, Inc. and La Jolla Institute for Immunology Announce Five-Year Research Alliance Agreement

    Cytocom, Inc. announced a collaboration agreement to fund research and laboratory facilities at the La Jolla Institute for Immunology. The agreement is directed to research that will support the development of potential new immune-modulating agents targeting toll-like receptors for the treatment of cancer, infectious, autoimmune and chronic inflammatory diseases.
    [Cytocom, Inc.]

    Press Release

    Gift to Propel Precision Medicine Research, Training at Harvard Medical School, Clalit Research Institute

    Harvard Medical School in Boston and Clalit Research Institute in Tel Aviv are launching a joint precision medicine effort, enabled by a donation from the Berkowitz family, with the intent of untangling the precise factors that underlie such medical mysteries can illuminate individualized treatments based on a person’s genetic predispositions, immune profile, health history, and lifestyle.
    [The Harvard Gazette]

    Press Release
    FEATURED EVENT

    Immuno US

    February 7 – 8, 2022
    San Diego, California, United States

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    JOB OPPORTUNITIES

    Research Fellow – Cancer Immunology and Stem Cells Research

    Dana-Farber Cancer Institute- Boston, Massachusetts, United States

    Assistant/Associate/Full Professor Tenure-Track – Aging and Inflammation

    Medical College of Georgia, Augusta University – Augusta, Georgia, United States

    Faculty Position – Cancer Biology and Signal Transduction

    Purdue University – West Lafayette, Indiana, United States

    Research Associate – Cell and Regenerative Biology

    University Of Wisconsin–Madison – Madison, Wisconsin, United States

    Investigator – Host Immunity and Microbiome

    National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States

    > See All Jobs

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