 | | Vol. 13.33 – 3 September, 2021 |
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| Researchers found that Neurofibromin 2 (NF2) facilitated innate immunity by regulating YAP/TAZ-mediated TBK1 inhibition. Patient-derived individual mutations in the FERM domain of NF2 converted NF2 into a potent suppressor of cGAS-STING signaling.
[Molecular Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors employed gene transfer into hematopoietic stem and progenitor cells to selectively express anti-tumoral cytokines in tumor-infiltrating monocytes/macrophages.
[EMBO Molecular Medicine] |
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| Investigators engineered a NK cell line to express CD64, the sole human high-affinity IgG Fcγ receptor, and bound these cells with antibodies to provide interchangeable tumor-targeting elements.
[Cancer Immunology Research] |
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| Researchers compared the immune profiles generated by KrasG12D-mutated mouse pancreatic ductal epithelial cells engineered genetically to express the Trp53R172H mutation with their p53 wild-type control.
[Cell Reports] |
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| Scientists investigated the effect of early-life antibiotic exposure on otherwise healthy, normal chow-fed, wild-type mice, monitoring these mice for more than 700 days in comparison with untreated control mice.
[Cell Reports] |
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| To gain functional insights into tissue-resident intestinal intraepithelial T lymphocytes (T-IEL), the authors used high-resolution, quantitative mass spectrometry to compare the proteomes of induced T-IEL and natural T-IEL subsets, with naive CD8+ T cells from lymph nodes.
[eLife] |
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| Scientists demonstrated that radiation exposure in mice promoted the expansion of splenic and intestinal myeloid-derived suppressor cells and caused intestinal inflammation due to the increased secretion of cytokines.
[Cell Death & Disease] |
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| Researchers established in vitro cultured mixed-natural killer cells (NKM) to achieve immune normalization. The in vitro cytotoxicity of NKM cells was tenfold higher than that of peripheral blood mononuclear cells
[Aging-Us] |
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| Researchers showed that tolinapant acted as an efficacious immunomodulatory molecule capable of inducing complete tumor regression in a syngeneic model of T cell lymphoma exclusively in the presence of an intact immune system.
[Blood Advances] |
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| Scientists showed that glutamine was a crucial regulator of endothelial to hematopoietic transition and a rate limiting metabolite in the hematopoietic differentiation of hemogenic endothelial cells.
[Scientific Reports] |
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| Scientists discuss six broad disease groups: infectious disease, cancer, metabolic disease, cardiovascular disease, autoimmune or inflammatory disease, and allergic and atopic diseases.
[Nature Reviews Gastroenterology & Hepatology] |
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| Investigators review recent advances that have expanded appreciation of the diversity of macrophage phenotypes in health and disease, emphasizing studies of liver, adipose tissue, and brain macrophages as paradigms for other tissue macrophages and cell types.
[Molecular Cell] |
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| The authors discuss the importance of oncolytic viruses-based combination therapies in optimizing antiviral and antitumor innate immune responses stimulated by virotherapy toward tumor eradication, and how these processes vary depending on the tumor and oncolytic viruses in question.
[Cancer Gene Therapy] |
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| Brickell Biotech, Inc. announced it has entered into a definitive agreement with Voronoi, Inc. that grants Brickell exclusive, worldwide rights to research, develop and commercialize novel therapeutics generated from a proprietary DYRK1A inhibitor platform.
[Brickell Biotech, Inc.] |
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| Two National Institute of Health (NIH) grants totaling over $1.3 million will enable research into antibody-mediated drug delivery technology for the treatment of cancer and autoimmune disorders. L. Nathan Tumey is the Principal Investigator on both grants — $1.2 million from the National Institute of General Medical Sciences and $150,000 from the National Institute of Allergy and Infectious Diseases.
[Bringhamton University] |
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| October 18 – 22, 2021
Washington, DC, United States & Online |
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| The University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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| | University of Miami – Miami, Florida, United States |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| University of North Dakota – Grand Forks, North Dakota, United States |
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| | Epitopea – Cambridge, England, United Kingdom |
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