Immune Regulation News Volume 13.36 | Oct 1 2021

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    Justin.choi
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    2021-10-01 | IRN 13.36


    Immune Regulation News by STEMCELL Technologies
    Vol. 13.36 – 1 October, 2021
    TOP STORY

    Site-Specific PEGylation of Interleukin-2 Enhances Immunosuppression via the Sustained Activation of Regulatory T Cells

    The authors showed that the pharmacokinetics and half-life of IL-2 could be substantially improved by orthogonally conjugating the cytokine to poly(ethylene glycol) (PEG) moieties via a copper-free click reaction through the incorporation of azide-bearing amino acids at defined sites.
    [Nature Biomedical Engineering]

    Full Article
    Who does immunology research in the Bolivian Andes? He does. Read Jason Young's story.
    PUBLICATIONSRanked by the impact factor of the journal

    CCR2 Deficiency Alters Activation of Microglia Subsets in Traumatic Brain Injury

    Researchers defined the heterogeneity of microglia and macrophage phenotypes during traumatic brain injury (TBI) in wild-type mice and Ccr2−/−` mice, which lacked macrophage influx following TBI and were resistant to brain damage.
    [Cell Reports]

    Full Article

    Early Life Exposure to House Dust Mite Allergen Prevents Experimental Allergic Asthma Requiring Mitochondrial H2O2

    Lung dendritic cells (DCs) from tolerized mice induced a low Th2 response in vitro mirroring impact of tolerance in vivo. Wild type-Tol mice displayed a decrease in total, cDC1 and cDC2 subsets in the lung as compared to that in naive mice.
    [Mucosal Immunology]

    Abstract

    Metabolomics Activity Screening of T Cell–Induced Colitis Reveals Anti-Inflammatory Metabolites

    Investigators used the T cell transfer mouse model of colitis to identify small-molecule metabolites with altered abundance due to intestinal inflammation.
    [Science Signaling]

    Abstract

    Alternative Splicing Regulation of Cell Cycle Genes by SPF45/SR140/CHERP Complex Controls Cell Proliferation

    Scientists reported that three splicing factors, SPF45, SR140 and CHERP formed a tight physical and functionally coherent complex that regulated a variety of alternative splicing events, frequently by repressing short exons flanked by suboptimal 3′ splice sites.
    [RNA]

    AbstractFull Article

    Regulation of the Immune Tolerance System Determines the Susceptibility to HLA-Mediated Abacavir-Induced Skin Toxicity

    The authors showed the importance of immune tolerance for idiosyncratic drug toxicity (IDT) onset and determine whether it was susceptible to a common IDT, HLA-B*57:01-mediated abacavir-induced hypersensitivity, using CD4+ T cell-depleted programmed death-1 receptor-deficient HLA-B*57:01 transgenic mice
    [Communications Biology]

    Full Article

    BTN2A2 Protein Negatively Regulates T Cells to Ameliorate Collagen-Induced Arthritis in Mice

    Researchers investigated the ability of a recombinant BTN2A2-IgG2a Fc fusion protein to treat Collagen type II (CIA). They showed that administration of BTN2A2-Ig attenuatex established CIA, as compared with control Ig protein treatment.
    [Scientific Reports]

    Full Article

    SEC61G Overexpression and DNA Amplification Correlates with Prognosis and Immune Cell Infiltration in Head and Neck Squamous Cell Carcinoma

    SEC61G expression was analyzed using publicly available datasets. The association between SEC61G and disease prognosis was evaluated.
    [Cancer Medicine]

    Full Article

    Lycopus lucidus Turcz Ameliorates DNCB-Induced Atopic Dermatitis in BALB/C Mice

    The authors determined whether Lycopus lucidus Turcz (LLT) could improve 2,4‑dinitrochlorobenzene‑induced dermatitis and to verify the inhibitory effect of LLT on the expression of chemokines and pro‑inflammatory cytokines in the HaCaT immortalized keratinocyte cell line.
    [Molecular Medicine Reports]

    Abstract

    This webinar provides insights and techniques for efficient leukopak sample processing and streamlined cell isolation.
    REVIEWS

    Role of the Gut Microbiome in Chronic Diseases: A Narrative Review

    Scientists detail the role of the gut microbiome in chronic diseases and ways it can be modulated for the management or prevention of chronic conditions.
    [European Journal of Clinical Nutrition]

    Abstract
    INDUSTRY AND POLICY NEWS

    Bio-Thera Solutions and Intract Pharma Enter Global Collaboration and License Agreement for Soteria® and Phloral® Drug Delivery Technologies to Enable Development of Oral Antibody Medicines

    Bio-Thera Solutions, Ltd. and Intract Pharma announced a global collaboration and licensing agreement that gives Bio-Thera access to Intract’s Soteria® and Phloral® drug delivery technologies to develop novel oral monoclonal antibody treatments for chronic gastrointestinal inflammatory diseases.
    [Bio-Thera Solutions, Ltd. (BusinessWire, Inc.)]

    Press Release

    TG Therapeutics Submits Biologics License Application to the US Food and Drug Administration for Ublituximab as a Treatment for Patients with Relapsing Forms of Multiple Sclerosis

    TG Therapeutics, Inc. announced the submission of a Biologics License Application to the FDA requesting approval of ublituximab, the company’s investigational glycoengineered anti-CD20 monoclonal antibody, as a treatment for patients with relapsing forms of multiple sclerosis.
    [TG Therapeutics, Inc.]

    Press Release
    FEATURED EVENT

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Tumor Immunology

    MD Anderson Cancer Center – Houston, Texas, United States

    Postdoctoral Fellow – Cancer Immunology

    Weill Cornell Medicine – New York, New York, United States

    Postdoctoral Researcher – Brain Stem Cell Researcher

    University of Helsinki – Helsinki, Finland

    Postdoctoral Associate – Mucosal Immunology

    Scripps Research Florida – Jupiter, Florida, United States

    Postdoctoral Researcher – Lung Immunology

    Karolinska Institutet – Stockholm, Sweden

    > See All Jobs

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