 | | Vol. 13.39 – 22 October, 2021 |
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| Investigators demonstrated that high levels of baseline CXCL13+ T cells were linked to the proinflammatory features of macrophages and could predict effective responses to the combination therapy.
[Cancer Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors described the development of a humanized monoclonal antibody, ICT01, with subnanomolar affinity for the three isoforms of BTN3A.
[Science Translational Medicine] |
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| Researchers assessed the role of cardiac immune cells in the early hypertrophy response to cardiac pressure overload-induced by transverse aortic constriction.
[Circulation Research] |
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| Investigators reported a bifunctional Janus particle probe to simultaneously monitor acidification and proteolysis in single phagosomes in live cells.
[Angewandte Chemie-International Edition] |
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| Scientists demonstrated that FRS2β, an adaptor protein expressed in a small subset of epithelial cells, triggered the proinflammatory changes that induced stroma in premalignant mammary tissues and was responsible for the disease onset.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| In the mouse aortocaval fistula model, anti-PD-L1 antibody was given to inhibit PD-L1 activity during arteriovenous fistulae maturation.
[Arteriosclerosis Thrombosis and Vascular Biology] |
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| The authors analyzed molecular changes within the epithelial and stromal compartments of dysplastic aberrant crypt foci formed in the ascending colon, where rapidly developing interval cancers occur.
[Molecular Cancer Research] |
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| Researchers developed, characterized and assessed whether chimeric heavy chain only antibodies against CTLA4 were viable therapeutic candidates for the treatment of canine cancers.
[Scientific Reports] |
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| Investigators systematically profiled chromatin accessibility on Th1, Th2, Th1-17, Th17, and Treg cells and found that chromatin remodeling contributed significantly to the pathogenesis of the disease.
[Frontiers of Medicine] |
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| The recent research progress on tumor-infiltrating B cells and T cells, including CD8+ T cells, CD4+ T cells, and exhausted T cells and their role in anti-tumor immunity, is summarized.
[Advanced Science] |
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| Infiltration and activity of CD8+ T cells is reduced in hypoxic conditions, whereas regulatory T cells and myeloid-derived suppressor cells show high activities.
[Life Sciences] |
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| ASLAN Pharmaceuticals announced a collaboration with renowned inflammatory skin disease expert Dr. Emma Guttman-Yassky to conduct research that will continue throughout ASLAN’s Phase IIb program to identify and characterize the effects of ASLAN004 on disease-associated skin and serum-biomarkers in adults with moderate-to-severe atopic dermatitis.
[ASLAN Pharmaceuticals] |
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| Regeneron Pharmaceuticals, Inc. and Sanofi announced positive pivotal Phase III results from a trial evaluating Dupixent® in adults with uncontrolled prurigo nodularis, a chronic type 2 inflammatory skin disease that causes extreme itch and skin lesions.
[Regeneron Pharmaceuticals, Inc.] |
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| November 10 – 11, 2021
Seoul, Korea & Online |
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| | Duke University – Durham, North Carolina, United States |
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| | Hong Kong University – Hong Kong, China |
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| | Medical University of Vienna – Vienna, Austria |
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| Brigham and Women’s Hospital and Harvard Medical School – Boston, Massachusetts, United States |
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