Immune Regulation News Volume 13.43 | Nov 19 2021

May 12, 2022

2021-11-19 | IRN 13.43

Immune Regulation News by STEMCELL Technologies

Vol. 13.43 – 19 November, 2021

TOP STORY

GOLM1 Exacerbates CD8⁺ T Cell Suppression in Hepatocellular Carcinoma by Promoting Exosomal PD-L1 Transport into Tumor-Associated Macrophages

Golgi membrane protein 1 (GOLM1) was positively correlated with infiltrating tumor-associated macrophages expressed high levels of programmed death-ligand 1 (PD-L1) and CD8⁺ T cell suppression in hepatocellular carcinoma tissues.
[Signal Transduction and Targeted Therapy]

Full Article

How can evaluating the immuno-oncology potential of compounds in vitro predict clinical outcomes? Watch this webinar by Dr. Alison O'Mahony, Eurofins DiscoverX

PUBLICATIONSRanked by the impact factor of the journal

Lactate Supports a Metabolic-Epigenetic Link in Macrophage Polarization

Investigators reported that interleukin-4 –induced M0 → M2 macrophage polarization was accompanied by interchangeable glucose- or lactate-dependent tricarboxylic acid cycle metabolism that directly drove histone acetylation, M2 gene transcription, and functional immune suppression.
[Science Advances]

Full Article

Dependence on Bcl6 and Blimp1 Drive Distinct Differentiation of Murine Memory and Follicular Helper CD4⁺ T Cells

Using single-cell RNA and ATAC sequencing, researchers showed that virus-responding CD4⁺ T cells lacking both Bcl6 and Blimp1 could differentiate into cells with transcriptomic, chromatin accessibility, and functional attributes of memory cells but not of follicular helper T cells.
[Journal of Experimental Medicine]

Abstract

A Novel Cytokine Consisting of the p40 and EBI3 Subunits Suppresses Experimental Autoimmune Arthritis via Reciprocal Regulation of Th17 and Treg Cells

The presence of the p40-EBI3 heterodimer was confirmed by ELISA, immunoprecipitation, and western blotting. A p40-EBI3 vector and p40-EBI3-Fc protein were synthesized to confirm the immunological role of this protein in mice with collagen-induced arthritis
[Cellular & Molecular Immunology]

Full Article

Autotaxin Impedes Anti-Tumor Immunity by Suppressing Chemotaxis and Tumor Infiltration of CD8⁺ T Cells

Investigators showed that autotaxin (ATC) secreted by melanoma cells was chemorepulsive for tumor-infiltrating lymphocytes and circulating CD8⁺ T cells ex vivo, with autotaxin functioning as an LPA-producing chaperone.
[Cell Reports]

Full Article Graphical Abstract

COMMD10 Is Critical for Kupffer Cell Survival and Controls Ly6C^hi Monocyte Differentiation and Inflammation in the Injured Liver

Copper metabolism MURR1 domain (COMMD10) deficiency in Kupffer cells and in other tissue-resident macrophages impedes their homeostatic survival, leading to their continuous replacement by Ly6C^hi monocytes.
[Cell Reports]

Abstract Graphical Abstract

Neutrophil Gelatinase-Associated Lipocalin From Macrophages Plays a Critical Role in Renal Fibrosis Via the CCL5 (Chemokine Ligand 5)-Th2 Cells-IL4 (Interleukin 4) Pathway

The role of the CCL5 and IL4 in kidney fibrosis was studied by administration of the CCL5 receptor antagonist maraviroc or by injections of an anti-IL4 neutralizing antibody.
[Hypertension]

Abstract

Oncolytic Adenovirus Inhibits Malignant Ascites of Advanced Ovarian Cancer via Reprograming Ascitic Immune Microenvironment

Scientists found that oncolytic adenovirus conferred an effective ability to reduce ascites development and prolong overall survival.
[Molecular Therapy-Oncolytics]

Abstract Press Release Graphical Abstract

A TNFR2 Antibody by Countering Immunosuppression Cooperates with HMGN1 and R848 Immune Stimulants to Inhibit Murine Colon Cancer

Researchers examined the efficacy of anti-TNFR2 antibody as an anti-tumor immune reagent combined with HMGN1and R848.
[International Immunopharmacology]

Abstract

As a scientist, how you separate the facts from the claims is just as important as how you separate your cells. See for yourself.

REVIEWS

Cellular Interactions in Resident Memory T Cell Establishment and Function

The authors highlight recent studies focusing on cellular interactions that regulate tissue resident memory T cells establishment and function.
[Current Opinion in Immunology]

Abstract

The Effect of α7nAChR Signaling on T Cells and Macrophages and Their Clinical Implication in the Treatment of Rheumatic Diseases

Investigators summarize the roles of different T cells and macrophages subsets in the occurrence and progression of rheumatoid arthritis (RA), and highlighted the immune consequences of cholinergic anti-inflammatory pathway activation in these cells under RA circumstances.
[Neurochemical Research]

Abstract

INDUSTRY AND POLICY NEWS

Revelation Biosciences, Inc. Announces Initiation of a Phase Ib Clinical Study of REVTx-99 for the Experimental Treatment of Allergic Rhinitis and Chronic Nasal Congestion

Revelation Biosciences, Inc. announced the initiation for its Phase Ib proof-of-concept nasal allergen challenge clinical study to evaluate the potential utility of REVTx-99 for treating patients with allergic rhinitis and patients with chronic nasal congestion without polyps.
[Revelation Biosciences, Inc.]

Press Release

Horizon Therapeutics plc Receives CHMP Positive Opinion for UPLIZNA^® (Inebilizumab) as a Monotherapy for the Treatment of Adult Patients with Neuromyelitis Optica Spectrum Disorder (NMOSD)

Horizon Therapeutics plc announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has adopted a positive opinion recommending marketing authorization for UPLIZNA^® as a monotherapy for the treatment of adult patients with NMOSD.
[Horizon Therapeutics plc]

Press Release

FEATURED EVENT

GOLM1 Exacerbates CD8⁺ T Cell Suppression in Hepatocellular Carcinoma by Promoting Exosomal PD-L1 Transport into Tumor-Associated Macrophages

Lactate Supports a Metabolic-Epigenetic Link in Macrophage Polarization

Dependence on Bcl6 and Blimp1 Drive Distinct Differentiation of Murine Memory and Follicular Helper CD4⁺ T Cells

A Novel Cytokine Consisting of the p40 and EBI3 Subunits Suppresses Experimental Autoimmune Arthritis via Reciprocal Regulation of Th17 and Treg Cells

Autotaxin Impedes Anti-Tumor Immunity by Suppressing Chemotaxis and Tumor Infiltration of CD8⁺ T Cells

COMMD10 Is Critical for Kupffer Cell Survival and Controls Ly6C^hi Monocyte Differentiation and Inflammation in the Injured Liver

Neutrophil Gelatinase-Associated Lipocalin From Macrophages Plays a Critical Role in Renal Fibrosis Via the CCL5 (Chemokine Ligand 5)-Th2 Cells-IL4 (Interleukin 4) Pathway

Oncolytic Adenovirus Inhibits Malignant Ascites of Advanced Ovarian Cancer via Reprograming Ascitic Immune Microenvironment

A TNFR2 Antibody by Countering Immunosuppression Cooperates with HMGN1 and R848 Immune Stimulants to Inhibit Murine Colon Cancer

Cellular Interactions in Resident Memory T Cell Establishment and Function

The Effect of α7nAChR Signaling on T Cells and Macrophages and Their Clinical Implication in the Treatment of Rheumatic Diseases

Revelation Biosciences, Inc. Announces Initiation of a Phase Ib Clinical Study of REVTx-99 for the Experimental Treatment of Allergic Rhinitis and Chronic Nasal Congestion

Horizon Therapeutics plc Receives CHMP Positive Opinion for UPLIZNA^® (Inebilizumab) as a Monotherapy for the Treatment of Adult Patients with Neuromyelitis Optica Spectrum Disorder (NMOSD)

British Society for Immunology (BSI) Congress

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Research Associate – Cancer, Immunity, and Stem Cell Biology

Research Scientist – Immunology

Postdoctoral Fellow – Bioinformatics

Scientist – Immune System-Tumor Interactions

Postdoctoral Fellow – Autoimmunity

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