Immune Regulation News Volume 13.46 | Dec 10 2021

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    2021-12-10 | IRN 13.46


    Immune Regulation News by STEMCELL Technologies
    Vol. 13.46 – 10 December, 2021
    TOP STORY

    Neutrophils Prevent Rectal Bleeding in Ulcerative Colitis by Peptidyl-Arginine Deiminase-4-Dependent Immunothrombosis

    The authors used high-resolution endoscopy and colon tissue samples of active ulcerative colitis as well as experimental models of physical and chemical mucosal damage in mice deficient for peptidyl-arginine deiminase-4, gnotobiotic mice and controls.
    [Gut]

    Abstract

    Register for the Immunometabolism at the Crossroads of Obesity and Cancer conference.
    PUBLICATIONSRanked by the impact factor of the journal

    Intestinal IL-33 Promotes Platelet Activity for Neutrophil Recruitment during Acute Inflammation

    Intestinal epithelium damage induced the elevated level of alarm cytokine interleukin-33 (IL-33), leading to platelet activation via promoting gut-derived serotonin release.
    [Blood]

    Abstract

    Bursty Gene Expression and mRNA Decay Pathways Orchestrate B Cell Activation

    The authors examined how during the course of B cell activation E2A and E2-2 gene expression was regulated.
    [Science Advances]

    Abstract

    NFAT-Dependent and -Independent Exhaustion Circuits Program Maternal CD8 T Cell Hypofunction in Pregnancy

    Scientists used mouse models and human transplant registry data to reveal that pregnancy induced exhausted CD8 T cells, which associated with prolonged allograft survival.
    [Journal of Experimental Medicine]

    Full Article

    TNF Plays a Crucial Role in Inflammation by Signaling via T Cell TNFR2

    Exposure of mouse CD4+ T cells to TNF and TGF-β generated Th17 cells that expressed low levels of IL-17 and high levels of inflammatory markers independently of IL-6 and STAT3.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Hobit Confers Tissue-Dependent Programs to Type 1 Innate Lymphoid Cells

    Using Zfp683 reporter mice, scientists showed that correlation of Hobit expression with type 1 innate lymphoid cells was tissue- and context-dependent.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    The Deubiquitinase OTUD1 Inhibits Colonic Inflammation by Suppressing RIPK1-Mediated NF-κB Signaling

    Investigators showed that loss of ovarian tumor deubiquitinase 1 (OTUD1) in mice contributed to the pathogenesis of dextran sulfate sodium-induced colitis via excessive release of proinflammatory cytokines.
    [Cellular & Molecular Immunology]

    Abstract

    Clinical Characterization and Immunosuppressive Regulation of CD161 (KLRB1) in Glioma through 916 Samples

    Retrospective RNA-seq data analysis was conducted in a cohort of 313 patients with glioma in the Chinese Glioma Genome Atlas database and 603 patients in the TCGA database.
    [Cancer Science]

    Abstract

    Intravenous Calcitriol Administration Modulates Mesenteric Lymph Node CD4+ T-cell Polarization and Attenuates Intestinal Inflammation in Obese Mice Complicated with Polymicrobial Sepsis

    Researchers investigated treatment with calcitriol on mesenteric lymph node CD4+ T cell polarization and intestinal injury in obese mice with sepsis.
    [Journal of Parenteral and Enteral Nutrition]

    Abstract
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    REVIEWS

    Early-Life Imprinting of Unconventional T Cells and Tissue Homeostasis

    Unconventional T cells compete for niches within tissues, and recent evidence supports the idea that the fundamental role of these cells in tissue physiology may result from their action as a network with overlapping and potentially synergistic functions, rather than as individual subsets.
    [Science]

    Full Article

    Spatial Determinates of Effector and Memory CD8+ T Cell Fates

    The authors detail the inflammatory and chemokine regulators of spatially restricted T cell differentiation, with a focus on how to promote stem-like memory cell.
    [Immunological Reviews]

    Abstract
    INDUSTRY AND POLICY NEWS

    The University of Colorado Anschutz Medical Campus and Orange Grove Bio to Collaborate on Development and Commercialization of Novel Therapies

    Orange Grove Bio and the University of Colorado Anschutz Medical Campus (CU Anschutz) announced the establishment of a collaboration with the goal of supporting the translation of cutting-edge research being conducted at CU Anschutz into the creation of innovative life science companies focused on the development of novel therapeutics.
    [Orange Grove Bio (GlobeNewswire, Inc.)]

    Press Release

    MRM Health Announces First Patient Dosed with Next Generation Live Microbiome Consortia Therapeutic MH002 in Phase Ib/IIa Study in Patients with Ulcerative Colitis

    MRM Health announced that the first patient received MH002 in a Phase Ib/IIa multi-center clinical trial in mild-to-moderate ulcerative colitis.
    [MRM Health]

    Press Release
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    JOB OPPORTUNITIES

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    Fred Hutch – Seattle, Washington, United States

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    Allen Institute – Seattle, Washington, United States

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