Immune Regulation News Volume 13.47 | Dec 17 2021

May 12, 2022

2021-12-17 | IRN 13.47

Immune Regulation News by STEMCELL Technologies

Vol. 13.47 – 17 December, 2021

TOP STORY

Anatomically Distinct Fibroblast Subsets Determine Skin Autoimmune Patterns

The authors identified subsets of dermal fibroblasts that were responsible for driving patterned autoimmune activity, by using a robust mouse model of vitiligo that was based on the activation of endogenous auto-reactive CD8⁺ T cells that targeted epidermal melanocytes.
[Nature]

Abstract

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PUBLICATIONSRanked by the impact factor of the journal

Stem-Like Intestinal Th17 Cells Give Rise to Pathogenic Effector T Cells during Autoimmunity

Researchers characterized the heterogeneity, plasticity, and migratory phenotypes of tissue Th17 cells in vivo by combined fate mapping with profiling of the transcriptomes and TCR clonotypes of over 84,000 Th17 cells at homeostasis and during CNS autoimmune inflammation.
[Cell]

Abstract Graphical Abstract

Infant T Cells Are Developmentally Adapted for Robust Lung Immune Responses through Enhanced T Cell Receptor Signaling

Mouse infant T cells showed increased sensitivity to low antigen doses, originating at the interface between T cells and antigen-bearing accessory cells—through actin-mediated mobilization of signaling molecules to the immune synapse.
[Science Immunology]

Abstract

Biomimetic Nanoparticles Deliver mRNAs Encoding Costimulatory Receptors and Enhance T Cell Mediated Cancer Immunotherapy

Researchers hypothesized that delivery of costimulatory receptor mRNA to tumor-infiltrating T cells will enhance the antitumor effects of antibodies.
[Nature Communications]

Full Article

TBK1 Recruitment to STING Mediates Autoinflammatory Arthritis Caused by Defective DNA Clearance

The authors found that the STING S365A mutation, which abrogated IRF3 binding and type I interferon induction, rescued the embryonic lethality of DNase II^−/− mice.
[Journal of Experimental Medicine]

Full Articles

Genome-Wide Fitness Gene Identification Reveals Roquin as a Potent Suppressor of CD8 T Cell Expansion and Anti-Tumor Immunity

Investigators performed in vivo and in vitro CRISPR screens to systematically identify genes influencing CD8 T cell expansion.
[Cell Reports]

Full Article Graphical Abstract

GPR120 Induces Regulatory Dendritic Cells by Inhibiting HK2-Dependent Glycolysis to Alleviate Fulminant Hepatic Failure

Scientists found that interference with GPR120 activity using pharmacological agonist attenuated the severity of the liver injury and mortality of fulminant hepatic failure in mice.
[Cell Death & Disease]

Full Article

CD4⁺ T-cell Activation of Bone Marrow Causes Bone Fragility and Insulin Resistance in Type 2 Diabetes

In type 2 diabetes mellitus mice, investigators inhibited systemic activation of T cells with a fusion protein between the extracellular domain of Cytotoxic T-Lymphocyte Antigen 4 and the Fc domain of human immunoglobulin G.
[Bone]

Abstract Graphical Abstract

Intercellular Interactions between Mast Cells and Stromal Fibroblasts Obtained from Canine Cutaneous Mast Cell Tumors

Scientists described the establishment of primary cocultures of neoplastic mast cells from canine cutaneous mast cell tumors and cancer-associated fibroblasts.
[Scientific Reports]

Full Articles

Meteorin-Like Facilitates Skeletal Muscle Repair through a Stat3/IGF-1 Mechanism

Investigators identified the myokine/cytokine Meteorin-like as a critical regulator of muscle regeneration.
[Nature Metabolism]

Abstract

Autophagy Promotes Growth of Tumors with High Mutational Burden by Inhibiting a T Cell Immune Response

Researchers showed that autophagy, especially in the liver, promoted tumor immune tolerance by enabling regulatory T-cell function and limiting stimulator of interferon genes, T-cell response and interferon-γ, which enables growth of high-tumor mutational burden tumors.
[Nature Cancer]

Abstract

Single-Cell Profiling of Immune System Alterations in Lymphoid, Barrier and Solid Tissues in Aged Mice

The authors revealed an atlas of age-related changes in the abundance and phenotype of immune cell populations across 12 mouse tissues.
[Nature Aging]

Full Article

REVIEWS

Rebalancing the Unbalanced Aged Immune System – a Special Focus on Zinc

Driven by this research, scientists provide a comprehensive and up-to-date overview of the various rebalancing capabilities of zinc in the unbalanced immune system of the elderly.
[Ageing Research Reviews]

Abstract Graphical Abstract

INDUSTRY AND POLICY NEWS

Alpine Immune Sciences and Horizon Therapeutics plc Announce Exclusive License and Collaboration Agreement to Develop Novel Protein-Based Therapies for Autoimmune and Inflammatory Diseases

Alpine Immune Sciences, Inc. and Horizon Therapeutics plc announced an exclusive license and collaboration agreement for the development and commercialization of up to four preclinical candidates generated from Alpine’s unique discovery platform.
[Alpine Immune Sciences, Inc.]

Press Release

Takeda Receives Positive CHMP Opinion for Vedolizumab IV for the Treatment of Active Chronic Pouchitis

Takeda Pharmaceutical Company Limited announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency has recommended the approval of intravenous vedolizumab for the treatment of adult patients with moderately to severely active chronic pouchitis.
[Takeda Pharmaceutical Company Limited]

Press Release

FEATURED EVENT

Anatomically Distinct Fibroblast Subsets Determine Skin Autoimmune Patterns

Stem-Like Intestinal Th17 Cells Give Rise to Pathogenic Effector T Cells during Autoimmunity

Infant T Cells Are Developmentally Adapted for Robust Lung Immune Responses through Enhanced T Cell Receptor Signaling

Biomimetic Nanoparticles Deliver mRNAs Encoding Costimulatory Receptors and Enhance T Cell Mediated Cancer Immunotherapy

TBK1 Recruitment to STING Mediates Autoinflammatory Arthritis Caused by Defective DNA Clearance

Genome-Wide Fitness Gene Identification Reveals Roquin as a Potent Suppressor of CD8 T Cell Expansion and Anti-Tumor Immunity

GPR120 Induces Regulatory Dendritic Cells by Inhibiting HK2-Dependent Glycolysis to Alleviate Fulminant Hepatic Failure

CD4⁺ T-cell Activation of Bone Marrow Causes Bone Fragility and Insulin Resistance in Type 2 Diabetes

Intercellular Interactions between Mast Cells and Stromal Fibroblasts Obtained from Canine Cutaneous Mast Cell Tumors

Meteorin-Like Facilitates Skeletal Muscle Repair through a Stat3/IGF-1 Mechanism

Autophagy Promotes Growth of Tumors with High Mutational Burden by Inhibiting a T Cell Immune Response

Single-Cell Profiling of Immune System Alterations in Lymphoid, Barrier and Solid Tissues in Aged Mice

Rebalancing the Unbalanced Aged Immune System – a Special Focus on Zinc

Alpine Immune Sciences and Horizon Therapeutics plc Announce Exclusive License and Collaboration Agreement to Develop Novel Protein-Based Therapies for Autoimmune and Inflammatory Diseases

Takeda Receives Positive CHMP Opinion for Vedolizumab IV for the Treatment of Active Chronic Pouchitis

AACR: Precision Prevention, Early Detection, and Interception of Cancer

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Postdoctoral Research Fellow – Immunotherapy, Stem Cell Transplantation and GVHD

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