 | | Vol. 14.00 – 7 January, 2022 |
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Scientists adapted a B cell pipeline for undocumented alleles, genotype, and haplotype inference for full and partial adaptive immune receptor repertoire sequencing T cell receptor data sets.
[Genome Medicine] |
|  | | PUBLICATIONSRanked by the impact factor of the journal |
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| In vivo subcutaneous tumor xenograft model, azoxymethane/dextran sodium sulfate -induced tumor mouse model and in vitro co-culture assays were used to investigate the Hmga2 role in tumor-associated macrophages recruitment and polarization.
[Theranostics] |
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| MC38 and B16-F10 tumor-bearing mouse models were established to investigate the role of FcγRIIB during tumor progression.
[Theranostics] |
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| A platelet lysate-rich plasma macroporous hydrogel scaffold with around 100 μm pore size and 1.25 MPa Young’s modulus was developed to sustainedly recruit and polarize endogenous anti-inflammatory macrophages for improving cartilage defect repair.
[Advanced Healthcare Materials] |
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| Investigators found that the tissue invasion of Drosophila macrophages, also known as plasmatocytes or hemocytes, utilized enhanced cortical F-actin levels stimulated by the Drosophila member of the fos proto oncogene transcription factor family.
[PLoS Biology] |
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| Researchers used a novel interleukin 35 reporter model to understand which signaling pathways were important for immunosuppressive properties in B cells.
[Frontiers in Immunology] |
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| The authors investigated the roles of zebrafish colony-stimulating factor receptor (Csf1rs) and their ligands – Csf1a, Csf1b and Il34, in embryonic and adult myelopoiesis.
[Blood Advances] |
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| Treatment with R10 fraction, isolated from garlic, was performed and the alterations in hormonal levels, T cell polarization markers, and expression of fertility-related genes were evaluated.
[Journal of Ovarian Research] |
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| After the inoculation of canine transmissible venereal tumors (CTVTs) and MCTVTs into immune-competent beagle dogs separately, MCTVTs grew faster and metastasized more frequently than CTVTs did.
[BMC Veterinary Medicine] |
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| Investigators discuss how tertiary lymphoid structures (TLSs) are detected and defined, the mechanism(s) of formation in cancer, and the potential of targeting TLSs for therapeutic benefit.
[Science] |
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| Scientists highlight how the use of high-resolution mass spectrometry to analyze T cell proteomes can improve our understanding of how these processes are regulated.
[Cellular & Molecular Immunology] |
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| The authors review the role of tumor-infiltrating Tregs in tumor progression and metabolic reprogramming of the tumor microenvironment.
[Cancer] |
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| TRex Bio Inc. announced that it has entered into a multi-year research collaboration and licensing agreement with Janssen Pharmaceutica NV, one of the Janssen Pharmaceutical Companies of Johnson & Johnson.
[TRexBio, Inc.] |
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| aTyr Pharma, Inc. announced that the FDA has granted the company orphan drug designation for its lead therapeutic candidate, ATYR1923, for the treatment of sarcoidosis.
[aTyr Pharma, Inc.] |
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| February 6-9, 2022
Keystone Resort, Colorado, United States |
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| Fox Chase Cancer Center, Temple University – Philadelphia, Pennsylvania, United States |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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| | Intima Bioscience – Cambridge, England, United Kingdom |
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| | Memorial Sloan Kettering – New York City, New York, United States |
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| | Allen Institute – Seattle, Washington, United States |
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