Immune Regulation News Volume 14.01 | Jan 14 2022

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    2022-01-14 | IRN 14.01


    Immune Regulation News by STEMCELL Technologies
    Vol. 14.01 – 14 January, 2022
    TOP STORY

    HLA-Independent T Cell Receptors for Targeting Tumors with Low Antigen Density

    The authors edited the TRAC locus in human peripheral blood T cells to engage cell-surface targets through their T cell receptor–CD3 complex reconfigured to utilize the same immunoglobulin heavy and light chains as a matched CAR.
    [Nature Medicine]

    Full Article
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    Androgen Receptor Signaling Promotes Treg Suppressive Function during Allergic Airway Inflammation

    Using androgen receptor (AR) deficient and Foxp3 fate-mapping mice, researchers determined that AR signaling increased Treg suppression during Alternaria extract challenge by stabilizing Foxp3+ Tregs and limiting the number of ST2+ ex-Tregs and IL-13+ Th2 and ex-Tregs.
    [Journal of Clinical Investigation]

    Abstract

    EBV+ Tumors Exploit Tumor Cell-Intrinsic and -Extrinsic Mechanisms to Produce Regulatory T Cell-Recruiting Chemokines CCL17 and CCL22

    Both in vitro and in vivo Treg migration was effectively blocked by a novel, small molecule antagonist of CCR4, CCR4-351.
    [PLoS Pathogens]

    Full Article

    Loss of CMTM6 Promotes DNA Damage-Induced Cellular Senescence and Antitumor Immunity

    Investigators showed that chemokine-like factor-like MARVEL transmembrane domain-containing family member 6 (CMTM6) was upregulated in clear cell renal cell carcinoma tissues and was strongly associated with advanced tumor grades, early metastases, and a worse prognosis.
    [Oncoimmunology]

    Full Article

    Fewer LAG-3+ T Cells in Relapsing-Remitting Multiple Sclerosis and Type 1 Diabetes

    The authors observed significantly fewer LAG-3+ CD4 and CD8 T cells from subjects with relapsing-remitting multiple sclerosis and type 1 diabetes.
    [Journal of Immunology]

    Abstract

    Long Noncoding RNA HOTAIRM1 Promotes Immunosuppression in Sepsis by Inducing T Cell Exhaustion

    Using a mouse model of sepsis, scientists found that the long noncoding RNA HOXA transcript antisense RNA myeloid-specific 1 (HOTAIRM1) was highly expressed in mice during the late phase of sepsis.
    [Journal of Immunology]

    Abstract

    Topical Astilbin Ameliorates Imiquimod-Induced Psoriasis-Like Skin Lesions in SKH-1 Mice via Suppression Dendritic Cell-Th17 Inflammation Axis

    Investigators found that astilbin inhibited R837-induced maturation and activation of bone marrow-derived dendritic cells and decreased the expression of pro-inflammatory cytokines by downregulating myeloid differentiation factor 88.
    [Journal of Cellular and Molecular Medicine]

    Full Article

    CCR2 Promotes Monocyte Recruitment and Intestinal Inflammation in Mice Lacking the Interleukin-10 Receptor

    The authorss asked whether CCR2 was necessary for the development of colitis in mice lacking the receptor for IL10.
    [Scientific Reports]

    Full Article

    Cytosporone B (Csn-B), an NR4A1 Agonist, Attenuates Acute Cardiac Allograft Rejection by Inducing Differential Apoptosis of CD4+ T Cells

    Researchers revealed that nuclear receptor subfamily 4 Group A member 1 was upregulated during cardiac allograft rejection and that the increased Nr4A1 was primarily localized in intragraft-infiltrating CD4+ T cells.
    [International Immunopharmacology]

    Abstract

    Control of Tumors by Antigen-Specific CD8+ T Cells through PDL1-Targeted Delivery of Antigenic Peptide

    Scientists generated a therapeutic chimeric protein containing the PD-L1 single-chain variable fragment linked to a cleavable model cytotoxic T lymphocyte epitope: E7 CTL peptide.
    [Journal of Immunology Research]

    Abstract
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    REVIEWS

    T Cells: Friends and Foes in NASH Pathogenesis and Hepatocarcinogenesis

    The authors review the specific functions of several T cell populations involved in NAFLD and NAFLD-driven HCC.
    [Hepatology]

    Abstract

    The Role of Indoleamine 2,3-Dioxygenase in Allergic Disorders

    A considerable number of studies suggest that the role of indoleamine 2,3 dioxygenase in T helper 2 cell regulation may be different from that of T helper 1 immune responses.
    [Molecular Biology Reports]

    Abstract

    INDUSTRY AND POLICY NEWS

    Emerald Health Pharmaceuticals Receives IND Clearance to Begin Phase II Clinical Trial of EHP-101 for Relapsing Forms of Multiple Sclerosis

    Emerald Health Pharmaceuticals, Inc. received clearance of its Investigational New Drug (IND) application by the FDA to begin enrolling patients in its Phase IIa clinical trial of EHP-101 for certain relapsing forms of multiple sclerosis (MS), specifically relapsing-remitting MS and active secondary progressive MS.
    [Emerald Health Pharmaceuticals, Inc. (GlobeNewswire, Inc.)]

    Press Release

    UHN and U of T Receive $24-Million Federal Grant for Transplant Research

    Researchers at University Health Network (UHN) and the University of Toronto (UoT) received $24 million to advance technology to repair and rebuild organs outside the body for patients in need.
    [University of Toronto]

    Press Release

    FEATURED EVENT

    Keystone Symposia – Cancer Neoantigens, Vaccines and Viruses

    February 6 – 10, 2022
    Banff, Alberta, Canada

    > See All Events

    JOB OPPORTUNITIES

    Senior Researcher – Biology

    UK Research and Innovation – Oxfordshire, England, United Kingdom

    Project Manager – Therapeutic Development Branch

    National Institute of Health – Rockville, Maryland, United States

    Faculty Position – Molecular Therapeutics

    Fox Chase Cancer Center, Temple University – Philadelphia, Pennsylvania, United States

    Postdoctoral Fellowship – Breast Cancer Immunology

    The University of Texas Southwestern Medical Center – Dallas, Texas, United States

    Senior Scientists – T Cells

    Intima Bioscience – Cambridge, England, United Kingdom

    > See All Jobs

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