Immune Regulation News Volume 14.02 | Jan 21 2022

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    Justin.choi
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    2022-01-21 | IRN 14.02


    Immune Regulation News by STEMCELL Technologies
    Vol. 14.02 – 21 January, 2022
    TOP STORY

    Immuno-Engineered Nanodecoys for the Multi-Target Anti-Inflammatory Treatment of Autoimmune Diseases

    IFN-γ treatment induced remarkable PD-L1 expression on PD-L1-expressing macrophage membrane (PRM), thereby allowing PRM nanodecoyss to bind mPD-1 on CD4+ T cell surfaces or neutralize free sPD-1, which reconstructed the PD-1/PD-L1 inhibitory axis to suppress CD4+ T cell activation and restore immune tolerance.
    [Advanced Materials]

    Abstract
    Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.
    PUBLICATIONSRanked by the impact factor of the journal

    Interleukin-37 Promotes Colitis-Associated Carcinogenesis via SIGIRR-Mediated Cytotoxic T Cells Dysfunction

    Scientists found that IL-37 transgenic mice were highly susceptible to colitis-associated colorectal cancer and suffered from dramatically increased tumor burdens in colon.
    [Signal Transduction and Targeted Therapy]

    Full Article

    FoxP3 Associates with Enhancer-Promoter Loops to Regulate Treg-Specific Gene Expression

    Investigators applied chromatin conformation capture with immunoprecipitation in Treg and closely related conventional CD4+ T cells.
    [Science Immunology]

    Abstract

    Functional Genomics Analysis Identifies T and NK Cell Activation as a Driver of Epigenetic Clock Progression

    Four clocks resulted in similar predictions of individual chronological age, and their constituting CpGs were correlated in DNA methylation level and were enriched for similar histone modifications and chromatin states.
    [Genome Biology]

    Full Article

    Long-Acting Recombinant Human Interleukin-7, NT-I7, Increases Cytotoxic CD8+ T Cells and Enhances Survival in Mouse Glioma Models

    Researchers assessed regulatory T cells and cytotoxic T lymphocytes in the tumor microenvironment, cervical lymph nodes, spleen, and thymus; and hematopoietic stem and progenitor cells in the bone marrow.
    [Clinical Cancer Research]

    Abstract

    CD169+ Macrophages in Lymph Node and Spleen Critically Depend on Dual RANK and LTbetaR Signaling

    The authors demonstrated that lymph node CD169+ macrophages were dependent on direct lymphotoxin beta receptor signaling.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    ISM1 Protects Lung Homeostasis via Cell-Surface GRP78-Mediated Alveolar Macrophage Apoptosis

    Researchers reported that absence of isthmin 1 (ISM1) in mice led to increase in both alveolar macrophages number and functional heterogeneity, with enduring lung inflammation, progressive emphysema, and significant lung function decline, phenotypes similar to human obstructive pulmonary disease.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    DJ-1 Depletion Prevents Immunoaging in T Cell Compartments

    Investigators showed that loss of DJ-1 encoded by PARK7/DJ-1, causing early-onset familial Parkinson’s disease, unexpectedly diminished signs of immunoaging in T cell compartments of both human and mice.
    [EMBO Reports]

    Full Article

    Inhalation of Dimethyl Fumarate-Encapsulated Solid Lipid Nanoparticles Attenuate Clinical Signs of Experimental Autoimmune Encephalomyelitis and Pulmonary Inflammatory Dysfunction in Mice

    Scientists investigated the potential effects of solid lipid nanoparticles containing dimethyl fumarate, administered by inhalation on the clinical signs, central nervous system inflammatory response, and lung function changes in mice with experimental autoimmune encephalomyelitis.
    [Clinical Science]

    Abstract

    Autologous Humanized Mouse Models of iPSC-Derived Tumors Enable Characterization and Modulation of Cancer-Immune Cell Interactions

    The authors showed that fibroblastic, hepatic, or neural tumors were all efficiently infiltrated and partially or totally rejected by autologous immune cells in humanized mice.
    [Cell Reports Methods]

    Full ArticleGraphical Abstract
    SepMate™ PBMC Isolation
    REVIEWS

    Microenvironmental Influences on T Cell Immunity in Cancer and Inflammation

    Both in inflamed and cancer tissues, a wide range of changes in physical conditions and nutrient availability are now acknowledged to shape immunity.
    [Cellular & Molecular Immunology]

    Full Article

    Development of the Immune System in the Human Embryo

    Fetal B-1 and B-2 B cells involved in innate and adaptive immune responses, respectively, arise in staggered waves of development from distinct progenitors.
    [Pediatric Research]

    Abstract
    INDUSTRY AND POLICY NEWS

    ASLAN Pharmaceuticals Initiates Phase IIb Study of ASLAN004 (Eblasakimab) in Moderate-to-Severe Atopic Dermatitis

    ASLAN Pharmaceuticals announced that it has screened the first patient in its Phase IIb dose-ranging clinical study of eblasakimab in adults with moderate-to-severe atopic dermatitis.
    [ASLAN Pharmaceuticals]

    Press Release

    Revelation Biosciences, Inc. Announces First Patient Enrolled and Dosed in Phase Ib Clinical Study of REVTx-99 for the Treatment of Allergic Rhinitis

    Revelation Biosciences, Inc. announced that the first patient has been enrolled and dosed in a Phase Ib clinical study to evaluate the potential utility of REVTx-99 for treating patients with allergic rhinitis and patients with chronic nasal congestion without polyps.
    [Revelation Biosciences, Inc.]

    Press Release
    FEATURED EVENT

    Immuno US

    February 7 – 8, 2022
    San Diego, California, United States

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – T Cell Therapeutics

    Kyverna Therapeutics, Inc. – Emeryville, California, United States

    PhD Student – Chronic Lymphocytic Leukemia

    Luxembourg Institute of Health – Luxembourg, Luxembourg

    Senior Researcher – Biology

    UK Research and Innovation – Oxfordshire, England, United Kingdom

    Project Manager – Therapeutic Development Branch

    National Institute of Health – Rockville, Maryland, United States

    Faculty Position – Molecular Therapeutics

    Fox Chase Cancer Center, Temple University – Philadelphia, Pennsylvania, United States

    > See All Jobs

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