Immune Regulation News Volume 14.02 | Jan 28 2022

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    2022-01-28 | IRN 14.02


    Immune Regulation News by STEMCELL Technologies
    Vol. 14.02 – 28 January, 2022
    TOP STORY

    Effector Memory CD4+ T Cells Induce Damaging Innate Inflammation and Autoimmune Pathology by Engaging CD40 and TNFR on Myeloid Cells

    Investigators identified a critical signaling node that was engaged by effector memory T cells to mobilize a broad proinflammatory program in the innate immune system.
    [Science Immunology]

    Abstract

    Learn about immunological considerations for hPSC banking by watching Dr. David Turner's webinar from the Nature Research Round Table on hPSC Quality
    PUBLICATIONSRanked by the impact factor of the journal

    Skin and Heart Allograft Rejection Solely by Long-Lived Alloreactive TRM Cells in Skin of Severe Combined Immunodeficient Mice

    By grafting alloskin or heart into severe combined immunodeficient or Rag2KO mice in which a piece of induced CD4+ and/or CD8+ tissue-resident memory (TRM) cell–containing MHC-matched or syngeneic skin was transplanted in advance, researchers addressed this issue.
    [Science Advances]

    Full Article

    Gut Microbiota–Derived Metabolite 3-Idoleacetic Acid Together with LPS Induces IL-35+ B Cell Generation

    Scientists investigated the regulatory effects of the gut microbiota on IL-35+ cells by using genetically modified mouse models of obesity.
    [Microbiome]

    Full Article

    Myeloid Cell TBK1 Restricts Inflammatory Responses

    Investigators showed that TANK-binding kinase 1 (TBK1) served as a vital regulator of proinflammatory macrophage function and protected against tissue inflammation.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    CXCR3 Regulates Stem and Proliferative CD8+ T Cells during Chronic Infection by Promoting Interactions with DCs in Splenic Bridging Channels

    The authors observed distinct locations for parasite-specific T cell subsets, implying a link between differentiation and anatomical niches in the spleen.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Colon Stroma Mediates an Inflammation-Driven Fibroblastic Response Controlling Matrix Remodeling and Healing

    Researchers performed single-cell RNA-sequencing of colon-derived stromal cells and identified distinct classes of fibroblasts with gene signatures that were differentially regulated by chronic inflammation, including IL-11–producing inflammatory fibroblasts.
    [PLoS Biology]

    Full Article

    Sialic Acid Blockade in Dendritic Cells Enhances CD8+ T Cell Responses by Facilitating High-Avidity Interactions

    Scientists established cultures of murine bone marrow-derived dendritic cells that lacked sialic acid expression using a sialic acid-blocking mimetic Ac53FaxNeu5Ac.
    [Cellular and Molecular Life Sciences]

    Full Article

    M-CSF Supports Medullary Erythropoiesis and Erythroid Iron Demand Following Burn Injury through Its Activity on Homeostatic Iron Recycling

    The authors found M-CSF secretion was increased in burn patients and a murine model of post burn ACI, so they neutralized M-CSF in ACI mice to determine if erythropoiesis was improved.
    [Scientific Reports]

    Full Article
    Explore Antibodies for Immunology Research
    REVIEWS

    Tissue-Resident Memory T Cells in the Urogenital Tract

    The understanding of T cell memory responses changed drastically with the discovery that specialized T cell memory populations reside within peripheral tissues at key pathogen entry sites.
    [Nature Reviews Nephrology]

    Abstract

    Regulation of Activated T Cell Survival in Rheumatic Autoimmune Diseases

    Investigators review the molecular mechanisms that limit the duration of immune responses in health and discuss the factors that alter such regulation in the setting of systemic lupus erythematosus and rheumatoid arthritis.
    [Nature Reviews Rheumatology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Mustang Bio Provides an Update on its IND Application for MB-207, a Lentiviral Gene Therapy for Treatment of X-linked Severe Combined Immunodeficiency (“XSCID”) in Previously Transplanted Patients

    Mustang Bio, Inc. announced that the FDA has issued a hold, pending Chemistry, Manufacturing and Controls clearance, on the company’s Investigational New Drug (IND) application.
    [Mustang Bio, Inc.]

    Press Release

    Allergy Therapeutics Announces FDA Clearance of IND Application for Novel Peanut Allergy Vaccine Candidate VLP Peanut

    Allergy Therapeutics announced that the FDA cleared the group’s Investigational New Drug (IND) application for its novel virus-like particle (VLP)-based peanut allergy vaccine candidate.
    [Allergy Therapeutics]

    Press Release
    FEATURED EVENT

    Antibody Biology and Engineering

    March 13 – 18, 2022
    Ventura, California, United States

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    JOB OPPORTUNITIES

    Postdoctoral Researcher – Cell Death Research & Therapy

    Flanders Institute for Biotechnology – Leuven, Belgium

    Postdoctoral Positions – Atherosclerosis

    Columbia University – New York, New York, United States

    Research Associate – T Cell Therapeutics

    Kyverna Therapeutics, Inc. – Emeryville, California, United States

    PhD Student – Chronic Lymphocytic Leukemia

    Luxembourg Institute of Health – Luxembourg, Luxembourg

    Senior Researcher – Biology

    UK Research and Innovation – Oxfordshire, England, United Kingdom

    > See All Jobs

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