| Vol. 14.03 – 4 February, 2022 |
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| Investigators utilized mouse models of reperfused myocardial infarction, angiotensin II and phenylephrine infusion, and diphtheria toxin cardiomyocyte ablation to investigate C-C chemokine ligand 17. [Circulation] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| The authors identified and characterize skin-resident T cells in humans defined by their long-term in situ lodgment. [Science Immunology] |
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| eEF-2K KO CD8+ T cells were more metabolically active and showed hyperactivation of the Akt-mTOR-S6K pathway. [Science Advances] |
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| Researchers demonstrated that aspirin increased concentrations of the immune-regulatory aspirin-triggered (AT) specialized proresolving mediators, including AT-lipoxin A4 and AT-resolvin D1, in colonic tissues during inflammation-associated colorectal cancer. [Science Advances] |
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| Investigators observed that anti–PD-1 therapy depends on IL-2 signaling, which raised the possibility that a lack of IL-2 limited anti–PD-1–induced effector T cell expansion. [Journal of Clinical Investigation] |
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| The authors investigated the effects of obesity on CD8 T cells in mouse models and patients with endometrial cancer. [Journal of Experimental Medicine] |
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| Scientists showed that the apical kinase of the Drosophila immune deficiency pathway Tak1, as well as its co-activator Tab2, were both selective autophagy substrates that interacted with the autophagy protein Atg8a. [Cell Reports] |
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| Dendritic cells were either generated from monocytes or isolated directly from blood of healthy donors or graft-versus-host disease patients and co-cultured in a mixed lymphocyte reaction with T cells obtained from healthy donors or transplantation bags. [Haematologica] |
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| Investigators identified Zfp335 transcription factor as a new player in the regulatory network controlling thymocyte development in mice. [eLife] |
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| Scientists discussed known T cell–microbe interactions in the gut and placed them in the context of an algorithmic framework of recognition, context-dependent interpretation, and response circuits across multiple levels of microbial recognition resolution. [Annual Reviews of Immunology] |
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| The authors discuss how recent investigations have uncovered the key contributions of T follicular helper and B cells and their coordinated actions in driving donor-specific antibody generation and immune progression towards antibody-mediated rejection. [Trends in Molecular Medicine] |
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| Revolo Biotherapeutics announced that it has received approval from the Medicines and Healthcare products Regulatory Agency to commence two Phase II clinical trials to evaluate its immune-resetting drug candidate, ‘1805, in patients with autoimmune diseases, one in people with moderate to severe active Rheumatoid Arthritis. [Revolo Biotherapeutics] |
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| Tiziana Life Sciences Ltd announced submission of an amendment to an Investigational New Drug application for evaluation of orally administered capsules of foralumab, which it believed would be the first “take home” immunotherapy, in patients with mild-to-moderately active Crohn’s Disease. [Tiziana Life Sciences Ltd] |
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| March 9 – 11, 2022 Melbourne, Victoria, Australia |
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| King’s College London- London, England, United Kingdom |
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| Osaka University – Osaka, Japan |
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| Flanders Institute for Biotechnology – Leuven, Belgium |
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| Columbia University – New York, New York, United States |
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| Kyverna Therapeutics, Inc. – Emeryville, California, United States |
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