Immune Regulation News Volume 14.03 | Feb 4 2022

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    2022-02-04 | IRN 14.03


    Immune Regulation News by STEMCELL Technologies
    Vol. 14.03 – 4 February, 2022
    TOP STORY

    CCL17 Aggravates Myocardial Injury by Suppressing Recruitment of Regulatory T Cells

    Investigators utilized mouse models of reperfused myocardial infarction, angiotensin II and phenylephrine infusion, and diphtheria toxin cardiomyocyte ablation to investigate C-C chemokine ligand 17.
    [Circulation]

    Abstract
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    Human Skin-Resident Host T Cells Can Persist Long Term after Allogeneic Stem Cell Transplantation and Maintain Recirculation Potential

    The authors identified and characterize skin-resident T cells in humans defined by their long-term in situ lodgment.
    [Science Immunology]

    AbstractPress Release

    Elongation Factor-2 Kinase Is a Critical Determinant of the Fate and Antitumor Immunity of CD8+ T Cells

    eEF-2K KO CD8+ T cells were more metabolically active and showed hyperactivation of the Akt-mTOR-S6K pathway.
    [Science Advances]

    Full Article

    Aspirin Activates Resolution Pathways to Reprogram T Cell and Macrophage Responses in Colitis-Associated Colorectal Cancer

    Researchers demonstrated that aspirin increased concentrations of the immune-regulatory aspirin-triggered (AT) specialized proresolving mediators, including AT-lipoxin A4 and AT-resolvin D1, in colonic tissues during inflammation-associated colorectal cancer.
    [Science Advances]

    Full Article

    Selective Delivery of Low-Affinity IL-2 to PD-1+ T Cells Rejuvenates Antitumor Immunity with Reduced Toxicity

    Investigators observed that anti–PD-1 therapy depends on IL-2 signaling, which raised the possibility that a lack of IL-2 limited anti–PD-1–induced effector T cell expansion.
    [Journal of Clinical Investigation]

    Full ArticleGraphical Abstract

    Suppressive Effects of the Obese Tumor Microenvironment on CD8 T Cell Infiltration and Effector Function

    The authors investigated the effects of obesity on CD8 T cells in mouse models and patients with endometrial cancer.
    [Journal of Experimental Medicine]

    Full Article

    Selective Autophagy Controls Innate Immune Response through a TAK1/TAB2/SH3PX1 Axis

    Scientists showed that the apical kinase of the Drosophila immune deficiency pathway Tak1, as well as its co-activator Tab2, were both selective autophagy substrates that interacted with the autophagy protein Atg8a.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Human Invariant Natural Killer T Cells Promote Tolerance by Preferential Apoptosis Induction of Conventional Dendritic Cells

    Dendritic cells were either generated from monocytes or isolated directly from blood of healthy donors or graft-versus-host disease patients and co-cultured in a mixed lymphocyte reaction with T cells obtained from healthy donors or transplantation bags.
    [Haematologica]

    Full Article

    Zinc Finger Protein Zfp335 Controls Early T Cell Development and Survival through β-Selection-Dependent and -Independent Mechanisms

    Investigators identified Zfp335 transcription factor as a new player in the regulatory network controlling thymocyte development in mice.
    [eLife]

    Abstract
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    REVIEWS

    T Cell Responses to the Microbiota

    Scientists discussed known T cell–microbe interactions in the gut and placed them in the context of an algorithmic framework of recognition, context-dependent interpretation, and response circuits across multiple levels of microbial recognition resolution.
    [Annual Reviews of Immunology]

    Abstract

    Adaptive Immune Cell Responses as Therapeutic Targets in Antibody-Mediated Organ Rejection

    The authors discuss how recent investigations have uncovered the key contributions of T follicular helper and B cells and their coordinated actions in driving donor-specific antibody generation and immune progression towards antibody-mediated rejection.
    [Trends in Molecular Medicine]

    Abstract
    INDUSTRY AND POLICY NEWS

    Revolo Biotherapeutics Receives MHRA Approval for Two Phase II Clinical Trials of ‘1805 in Autoimmune Diseases in the United Kingdom

    Revolo Biotherapeutics announced that it has received approval from the Medicines and Healthcare products Regulatory Agency to commence two Phase II clinical trials to evaluate its immune-resetting drug candidate, ‘1805, in patients with autoimmune diseases, one in people with moderate to severe active Rheumatoid Arthritis.
    [Revolo Biotherapeutics]

    Press Release

    Tiziana Announces Submission of Amendment to Investigational New Drug Application to Advance Oral Foralumab, a Fully Human Anti-CD3 Monoclonal Antibody, in Patients with Crohn’s Disease

    Tiziana Life Sciences Ltd announced submission of an amendment to an Investigational New Drug application for evaluation of orally administered capsules of foralumab, which it believed would be the first “take home” immunotherapy, in patients with mild-to-moderately active Crohn’s Disease.
    [Tiziana Life Sciences Ltd]

    Press Release
    FEATURED EVENT

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    March 9 – 11, 2022
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    JOB OPPORTUNITIES

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    King’s College London- London, England, United Kingdom

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    Osaka University – Osaka, Japan

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    Flanders Institute for Biotechnology – Leuven, Belgium

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    Columbia University – New York, New York, United States

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    Kyverna Therapeutics, Inc. – Emeryville, California, United States

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