Immune Regulation News Volume 14.05 | Feb 11 2022

May 12, 2022

2022-02-11 | IRN 14.05

Immune Regulation News by STEMCELL Technologies

Vol. 14.05 – 11 February, 2022

TOP STORY

Marginal Zone B Cells Acquire Dendritic Cell Functions by Trogocytosis

Scientists determined that complement component 3 bound to peptide-loaded major histocompatibility complex class II molecules exposed on the surface of mouse and human conventional dendritic cells, forming a covalent bond with the carbohydrate moiety of the MHC II α chain.
[Science]

Abstract

Quantify Cytokines with Confidence with High-Performance ELISA Kits

PUBLICATIONSRanked by the impact factor of the journal

Loss of TSC1/TSC2 Sensitizes Immune Checkpoint Blockade in Non–Small Cell Lung Cancer

Researchers found that TSC1/TSC2 loss defined a distinct subtype of non-small cell lung cancercharacterized as inflamed tumor microenvironment and superior sensitivity to immune checkpoint blockade.
[Science Advances]

Full Article

DExD/H-box Helicase 9 Intrinsically Controls CD8⁺ T Cell–Mediated Antiviral Response through Noncanonical Mechanisms

Investigators found that T cell–specific deletion of nuclear helicase Dhx9 led to impaired CD8⁺ T cell survival, effector differentiation, and viral clearance.
[Science Advances]

Full Article

Combining p53 mRNA Nanotherapy with Immune Checkpoint Blockade Reprograms the Immune Microenvironment for Effective Cancer Therapy

The authors developed and optimized a CXCR4-targeted mRNA nanoparticle platform to effectively induce p53 expression in hepatocellular carcinoma models.
[Nature Communications]

Full Article Press Release

Glutaredoxin 1 Controls Monocyte Reprogramming during Nutrient Stress and Protects Mice against Obesity and Atherosclerosis in a Sex-Specific Manner

Researchers reported that in chow-fed, reproductively senescent female mice but not in age-matched male mice, deficiency in the thiol transferase glutaredoxin 1 promoted dysregulated macrophage phenotypes as well as rapid weight gain and atherogenesis.
[Nature Communications]

Full Article

Post-Transplant Malignancies Show Reduced T Cell Abundance and Tertiary Lymphoid Structures as Correlates of Impaired Cancer Immunosurveillance

Digital image analysis of whole section slides was used to assess abundance and spatial distribution of T cells and tertiary lymphoid structures in the tumor immune microenvironment of 117 tumor samples.
[Clinical Cancer Research]

Abstract

Single-Cell Transcriptomics Uncovers an Instructive T Cell Receptor Role in Adult γδ T Cell Lineage Commitment

Single-cell transcriptomics of LAT-deficient double-negative third stage γδ^int cells demonstrated no sign of commitment to the γδ T-cell lineage, apart from γδ T cell receptor expression.
[EMBO Journal]

Full Article Graphical Abstract

Natural Disaster and Immunological Aging in a Nonhuman Primate

Scientists examined the impact of Hurricane Maria and its aftermath on immune cell gene expression in large, age-matched, cross-sectional samples from free-ranging rhesus macaques living on an isolated island.
[Proceedings of the National Academy of Sciences of the United States of America]

Abstract

Activation and Expansion of T-Follicular Helper Cells in Chronic Lymphocytic Leukemia Nurselike Cell Co-Cultures

In co-cultures from 28 different chronic lymphocytic leukemia patients, the authors detected an expansion of T-follicular helper cells based on PD-1, BCL6, and ICOS expression, with increased IL-21 and downmodulated CD40L surface expression.
[Leukemia]

Abstract

NAFLD Indirectly Impairs Antigen Specific CD8⁺ T Cell Immunity against Liver Cancer in Mice

Scientists generated a doxycycline inducible MHC-I and II antigen expressing hepatocellular carcinoma cell line which allowed them to investigate tumor antigen specific T cell response in two non-alcoholic fatty liver disease (NAFLD) mouse models.
[iScience]

Abstract Graphical Abstract

In Situ Vaccination Using Unique TLR9 Ligand K3-SPG Induces Long-Lasting Systemic Immune Response and Synergizes with Systemic and Local Immunotherapy

K3-SPG, a second-generation nanoparticulate Toll-like receptor 9 (TLR9) ligand consisting of K-type CpG oligodeoxynucleotide (ODN) wrapped with schizophyllan, integrated the best of conventional CpG ODNs, making it an ideal cancer immunotherapy adjuvant.
[Scientific Reports]

Full Article

REVIEWS

Activation Pathways That Drive CD4⁺ T Cells to Break Tolerance in Autoimmune Diseases

Investigators review our current understanding of how each of the three signals of CD4+ T cell activation cell plays a role in three different autoimmune diseases and highlight the genetic polymorphisms that predispose individuals to autoimmunity.
[Immunological Reviews]

Abstract

Regulation of Immune Cell Function by Nicotinamide Nucleotide Transhydrogenase

The authors provides] an overview of nucleotide transhydrogenase (NNT) and focus on the current knowledge of NNT in the immune cells.
[American Journal of Physiology-Cell Physiology]

Abstract

INDUSTRY AND POLICY NEWS

Intrommune Reports Positive Update from Ongoing Phase I Study in Peanut Allergy

Intrommune Therapeutics, Inc. announced an initial update from its ongoing Phase I OMEGA Trial of INT301 in patients with peanut allergy.
[Intrommune Therapeutics, Inc.]

Press Release

Husker Researcher Takes Another Step toward Virtual Immune System

The renewal of a National Institutes of Health grant will enable a University of Nebraska–Lincoln researcher to continue developing a tool that illuminates the complex, multi-scale interplay of the immune system’s many components.
[Nebraska Today]

Press Release

FEATURED EVENT

Marginal Zone B Cells Acquire Dendritic Cell Functions by Trogocytosis

Loss of TSC1/TSC2 Sensitizes Immune Checkpoint Blockade in Non–Small Cell Lung Cancer

DExD/H-box Helicase 9 Intrinsically Controls CD8⁺ T Cell–Mediated Antiviral Response through Noncanonical Mechanisms

Combining p53 mRNA Nanotherapy with Immune Checkpoint Blockade Reprograms the Immune Microenvironment for Effective Cancer Therapy

Glutaredoxin 1 Controls Monocyte Reprogramming during Nutrient Stress and Protects Mice against Obesity and Atherosclerosis in a Sex-Specific Manner

Post-Transplant Malignancies Show Reduced T Cell Abundance and Tertiary Lymphoid Structures as Correlates of Impaired Cancer Immunosurveillance

Single-Cell Transcriptomics Uncovers an Instructive T Cell Receptor Role in Adult γδ T Cell Lineage Commitment

Natural Disaster and Immunological Aging in a Nonhuman Primate

Activation and Expansion of T-Follicular Helper Cells in Chronic Lymphocytic Leukemia Nurselike Cell Co-Cultures

NAFLD Indirectly Impairs Antigen Specific CD8⁺ T Cell Immunity against Liver Cancer in Mice

In Situ Vaccination Using Unique TLR9 Ligand K3-SPG Induces Long-Lasting Systemic Immune Response and Synergizes with Systemic and Local Immunotherapy

Activation Pathways That Drive CD4⁺ T Cells to Break Tolerance in Autoimmune Diseases

Regulation of Immune Cell Function by Nicotinamide Nucleotide Transhydrogenase

Intrommune Reports Positive Update from Ongoing Phase I Study in Peanut Allergy

Husker Researcher Takes Another Step toward Virtual Immune System

Cell Therapy Analytics Symposium

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Postdoctoral Scientist – Cellular Immunology/T Cell Therapy

Postdoctoral Research Scientist – Immune Regulation

Research Scientist – T Cell Stimulation

Postdoctoral Fellow – Cell Death in the Innate Immune System

Postdoctoral Positions – Atherosclerosis

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