 | | Vol. 14.06 – 18 February, 2022 |
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| Scientists characterized the mycobiota biogeography along the gastrointestinal tract and identified a subset of fungi associated with the intestinal mucosa of mice and humans.
[Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers investigated the immunological effect of chiral nanomaterials as therapeutic and preventive options against tumors.
[Advanced Materials] |
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| Interruption of T cell antigen receptors-mediated ‘normality sensing’ had no impact on γδ T cell numbers but altered their signature phenotype, while the epidermal barrier function was compromised.
[Nature Immunology] |
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| Investigators studied the safety and preclinical efficacy of using these enzymes to remove A antigen from human donor lungs using ex vivo lung perfusion.
[Science Translational Medicine] |
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| The authors demonstrate that activated T cells armed with anti-CD3 x anti-EGFR bispecific antibody increases tumor infiltrating lymphocytes and mediate anti-tumor cytotoxicity while decreasing tumor cell viability.
[Oncogene] |
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| Scientists reported specifically elevated expression of IL-36α, and not IL-36β or IL-36γ in the serum of newly diagnosed, treatment naïve, pediatric inflammatory bowel diseases patients and identify T cells as primary cellular mediators of IL-36 responses in the inflamed gut.
[Mucosal Immunology] |
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| The authors investigated whether Themis plays a direct role in cytokine signaling in mature T cells.
[Science Signaling] |
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| Within LPS-treated MODE-K cells, METTL3 knockdown promoted cell viability, inhibited cell apoptosis, decreased apoptotic caspase3/9 cleavage, and decreased the levels of proinflammatory cytokines and inflammatory enzymes
[Cell Death Discovery] |
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| Gene expression was measured in mice receiving no immunotherapy; and in which anaphylaxis could never occur.
[Scientific Reports] |
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| Researchers focused on the effects and mechanisms of the Astragali Radix and Coptis Rhizoma herb pair attenuation of atherosclerosis in apolipoprotein E knockout (ApoE-/-) mice.
[Evidence-Based Complementary and Alternative Medicine] |
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| Scientists summarizes the critical mediators and mechanisms involved in immune cell trafficking in IBD and the available evidence for efficacy, safety and pharmacokinetics of sphingosine 1-phosphate receptor modulators in IBD and other immune-mediated disorders.
[Nature Reviews Gastroenterology & Hepatology] |
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| The authors review the recent literature that describes the changes induced in immune cells following internalization of cargo-free particles.
[Trends in Pharmacological Sciences] |
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| Statera Biopharma, Inc. announced that it has received Central Institutional Review Board approval to conduct a Phase III clinical trial for STAT-201 in the treatment of pediatric Crohn’s Disease, a chronic relapsing inflammatory condition of the gastrointestinal tract.
[Statera Biopharma, Inc.] |
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| OSE Immunotherapeutics SA announced that Veloxis Pharmaceuticals, Inc. has obtained fast track designation from the FDA for VEL-101/FR104, a novel investigational maintenance immunosuppressive agent being developed for prophylaxis of renal allograft rejection in recipients of kidney transplants.
[OSE Immunotherapeutics SA] |
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| 29 – 31 March, 2022
Boston, Massachusetts, United States |
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| | University of Lausanne – Lausanne, Switzerland |
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| | Columbia University – New York, New York, United States |
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| TU Dresden – Dresden, Germany |
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| | Babraham Institute – Babraham, England, United Kingdom |
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| | Ragon Institute – Boston, Massachusetts, United States |
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