 | | Vol. 14.07 – 25 February, 2022 |
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| Scientists demonstrated that a trispecific antibody to HER2, CD3 and CD28 stimulated regression of breast cancers in a humanized mouse model through a mechanism involving CD4-dependent inhibition of tumor cell cycle progression.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers investigated how changes to naive CD8+ T cell gene expression depended on the basic leucine zipper ATF-like transcription factor Batf, which was essential for the early phases of the process.
[Science Immunology] |
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| The authors reported the identification of hepatitis C virus NS5A inhibitors Pibrentasvir and Ombitasvir as SARS-CoV-2 exonuclease inhibitors.
[Communications Biology] |
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| Scientists tested whether perinatal intake of a multispecies probiotic could mitigate the abnormal emotional behavior in the juvenile and adult offspring of obese dams.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators used modeling to show that the unbinding rate of tandem, but not single, Src homology 2 domains could be accelerated by phosphatases.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers found that diminished expression of a model tissue-restricted antigen gene in aged thymic stromal cells correlated with impaired clonal deletion of cognate T cells recognizing an autoantigen involved in atherosclerosis.
[Cell Reports] |
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| Scientists reported that mice with Treg cell–specific ablation of miR-142 developed a fatal systemic autoimmune disorder due to a breakdown in peripheral T cell tolerance.
[PLoS Biology] |
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| Investigators evaluated the anti-inflammatory and antioxidant effects of 18β-GA in an ovalbumin-induced asthma mouse model, and examined the role of NF-κB and Nrf2/HO-1 signaling pathways.
[Scientific Reports] |
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| Murine splenocytes were differentiated into T helper 17 cells, and the effect of the TGF-βRI inhibitor SB-505124 was studied.
[Scientific Reports] |
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| IL-2 biologics have proven to be effective in preclinical studies and clinical assessment of some is now underway.
[Nature Reviews Immunology] |
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| Investigators hypothesize that memory responses to antigens from the microbiota must be ‘licensed’ by inflammatory signals activated by invasion of the host by microorganisms.
[Mucosal Immunology] |
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| MyMD Pharmaceuticals, Inc. announced that the first patient has been enrolled in the company’s Phase II clinical trial of lead candidate MYMD-1, an oral immune regulator drug, as a therapy for delaying aging and expanding healthy lifespan.
[MyMD Pharmaceuticals, Inc. (BusinessWire, Inc.)] |
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| Dr. Vishva Dixit has received the Vilcek Prize in Biomedical Science for his groundbreaking discoveries on the mechanism of apoptosis.
[The Vilceck Foundation] |
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| March 19 – 22, 2022
Sitges, Spain |
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| | Genetech – South San Francisco, California, United States of America |
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| | University of Lausanne – Lausanne, Switzerland |
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| | Columbia University – New York, New York, United States |
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| TU Dresden – Dresden, Germany |
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| | Babraham Institute – Babraham, England, United Kingdom |
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Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
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