 | | Vol. 14.09 – 11 March, 2022 |
| |
|
|
| Researchers generated an epigenetic and transcriptional atlas of T cell differentiation from healthy humans that included exhausted CD8 T cells and applied this resource in three ways.
[Immunity] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| The authors identified a group of clonotypes, characterized by semi-invariant T cell receptor alpha chains, to be significantly enriched in the blood of patients with Crohn’s disease and particularly expanded in the CD8+ T cell population.
[Gut] |
|
|
|
| Researchers investigated the combination of IL-15 with an intratumoral anti-CD40 monoclonal antibody (mAb) in a dual tumor TRAMP-C2 murine prostate cancer model and expanded the regimen to include an anti-PD-1 mAb.
[Clinical Cancer Research] |
|
|
|
| Investigators showed that Tregs in tumor-bearing omenta predominantly had thymus-derived characteristics.
[Cancer Immunology Research] |
|
|
|
| Scientists studied the consequences of pAg-stimulated γδ T cell interactions with NK cells and CD8+ T cells, major innate and adaptive effectors, respectively.
[Cancer Immunology Research] |
|
|
|
| The authors investigated the impact of mammary tumorigenesis on regulatory T cells in distant organs and how this affected multi-organ metastatic disease.
[Cell Reports] |
|
|
|
| Scientists evaluated if acute exposure to JUUL e-cigarette aerosols in three popular flavors elicited an immunomodulatory or oxidative stress response in mice.
[Archives of Toxicology] |
|
|
|
| Investigators described that weaning rats fed diets rich in Maillard reaction products were affected in both their immune and endocrine systems.
[Scientific Reports] |
|
|
|
| Researchers investigated whether the EZH2 noncanonical pathway could be involved in early T cell maturation, which required cell polarization.
[Scientific Reports] |
|
|
|
| Tumor necrosis factor receptor-associated factor 6 (TRAF6)-overexpressing dendritic cells had increased expression of costimulatory molecules, major histocompatibility complex molecules and IL-12 expression.
[International Immunopharmacology] |
|  |
|
|
|
| The author discusses the increase in circulating follicular helper T cells seen in autoimmune settings and explores potential explanations for this phenomenon.
[Nature Reviews Immunology] |
|
|
|
| Scientists review the relationships between central nervous system macrophage populations, with a focus on the origins, phenotypes, and functions of cerebrospinal fluid macrophages in health and disease.
[Science Immunology] |
|
|
|
| Diagnosis of primary immune regulatory disorders is a significant challenge to physicians due to their rarity, complexity, and diversity in clinical manifestations.
[Orphanet Journal of Rare Diseases] |
|
|
|
|
| aTyr Pharma, Inc. announced the positive outcome of a Type B End-of-Phase II meeting with the FDA regarding its lead therapeutic candidate, efzofitimod, for the treatment of pulmonary sarcoidosis.
[aTyr Pharma, Inc.] |
|
|
|
|
| April 3 – April 5, 2022
Lisbon, Portugal |
|
|
|
|
|
| | University of Sherbrooke – Sherbrooke, Quebec, Canada |
|
|
|
| | King’s College London – London, England, United Kingdom |
|
|
|
| | Lee Kong Chian School of Medicine – Singapore, Singapore |
|
|
|
| | Monash University – Clayton, Australia |
|
|
|
| University of Virginia School of Medicine – Charlottesville, Virginia, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
