Immune Regulation News Volume 14.10 | Mar 17 2022

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    2022-03-18 | IRN 14.10


    Immune Regulation News by STEMCELL Technologies
    Vol. 14.10 – 18 March, 2022
    TOP STORY

    Type I Interferon Transcriptional Network Regulates Expression of Coinhibitory Receptors in Human T Cells

    Researchers showed that type 1 interferon regulated coinhibitory receptor expression on human T cells, inducing PD-1/TIM-3/LAG-3 while inhibiting T cell immunoreceptor with immunoglobulin and ITIM domains expression.
    [Nature Immunology]

    Full Article
    She wanted to join the battle against cancer. So she started a company. Read Sofie Pattijn's story.
    PUBLICATIONSRanked by the impact factor of the journal

    Bacterioboat — a Novel Tool to Increase the Half-Life Period of the Orally Administered Drug

    Investigators reported the development and deployment of Bacterioboat, which consisted of surface-encapsulated mesoporous nanoparticles on metabolically active Lactobacillus reuteri as a drug carrier suitable for oral administration.
    [Science Advances]

    Full Article

    Autophagy Impairment in Liver CD11c+ Cells Promotes Non-Alcoholic Fatty Liver Disease through Production of IL-23

    Thr authors explored the effect of Autophagy-related 5 (Atg5) deficiency in liver CD11c+ cells in mice fed high-fat diet. When compared to control mice, Atg5-deficient CD11c+ mice exhibited increased glucose intolerance and decreased insulin sensitivity when fed a HFD.
    [Nature Communications]

    Full Article

    Critical Role of WASp in Germinal Center Tolerance through Regulation of B Cell Apoptosis and Diversification

    Scientists showed that B cell responses remained T cell dependent in constitutive Wiskott-Aldrich syndrome protein (WASp)-deficient mice, whereas selective WASp deletion in germinal center B cells was sufficient to induce broad development of self-reactive antibodies and kidney pathology.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Immune Phenotype of the CD4+ T Cells in the Aged Lymphoid Organs and Lacrimal Glands

    Investigators characterized the immune phenotype of aged CD4+ T cells in the lacrimal gland as compared with lymphoid organs. Effector T helper 1 genes were highly upregulated on aged Tregs, including the master regulator Tbx21.
    [GeroScience]

    Abstract

    Mutant LRRK2 in Lymphocytes Regulates Neurodegeneration via IL-6 in an Inflammatory Model of Parkinson’s Disease

    Using two chimeric mouse models, scientists demonstrated that the replacement of mutant LRRK2 with wild-type formed of the protein in T- and B-lymphocytes diminished LPS-mediated inflammation and rescued the substantia nigra pars compacta dopamine neuron loss in the mutant LRRK2 brain.
    [npj Parkinsons Disease]

    Full Article

    In Situ Imaging for Tumor Microbiome Interactions via Imaging Mass Cytometry on Single-Cell Level

    Researchers developed a rapid semi-quantitative method for in situ imaging of bacteria and multiplex cell phenotypes on the same solid tumor tissue sections.
    [Cytometry Part A]

    Abstract

    Hsp70 Overexpression in Drosophila Hemocytes Attenuates Benzene-Induced Immune and Developmental Toxicity via Regulating ROS/JNK Signaling Pathway

    Drosophila larvae exposed to benzene were examined for total hemocyte count, phagocytic activity, oxidative stress, apoptosis, and their developmental delay and reduction were analyzed.
    [Environmental Toxicology]

    Abstract

    Age-Associated Impairment of T Cell Immunity Is Linked to Sex-Dimorphic Elevation of N-Glycan Branching

    The authors showed that branching of asparagine-linked glycans increased with age in females more than in males, in naive T cells more than in memory T cells, and in CD4+ more than in CD8+ T cells.
    [Nature Aging]

    Full Article
    Request your free copy of the 'Human Immune Cytokines' Wallchart
    REVIEWS

    Micro(nano)plastics Pollution and Human Health: How Plastics Can Induce Carcinogenesis to Humans?

    Investigators highlight microplastics’ and nanoplastics’ pathways to the food chains and how these plastic particles can cause risks to human health
    [Chemosphere]

    Abstract

    Primary Immune Regulatory Disorders: Undiagnosed Needles in the Haystack?

    Diagnosis of Pprimary immune regulatory disorders is a significant challenge to physicians due to their rarity, complexity, and diversity in clinical manifestations.
    [Orphanet Journal of Rare Diseases]

    Full Article
    INDUSTRY AND POLICY NEWS

    BioMed X Institute and Merck KGaA, Darmstadt, Germany, Start Second Research Project in Immunology

    A German independent research institute, BioMed X, announced the start of its new research project ‘Regulatory T Cell Dysfunction in Autoimmunity and Inflammaging’ in collaboration with Merck KGaA, Darmstadt, Germany.
    [BioMedX]

    Press Release

    AbbVie Expands Immunology Portfolio in Canada as Health Canada approves SKYRIZI® (Risankizumab) for the Treatment of Adults with Active Psoriatic Arthritis

    AbbVie announced Health Canada has approved SKYRIZI® for the treatment of adult patients with active psoriatic arthritis. In PsA, SKYRIZI can be used alone or in combination with a conventional non-biologic disease-modifying antirheumatic drug.
    [AbbVie]

    Press Release
    FEATURED EVENT

    1st International Symposium of Clinical Immunology

    April 2 – April 3
    Fukuoka, Japan and Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Lymphoid Malignancies

    Princess Margaret Cancer Center – Toronto, Ontario, Canada

    Staff Scientist – Aging Physiology and Pathology

    NIH National Institute on Aging – Baltimore, Maryland, United States

    Research Chair – Canada Excellence

    University of Sherbrooke – Sherbrooke, Quebec, Canada

    Assistant Professor – Skin Immunology

    Lee Kong Chian School of Medicine – Singapore, Singapore

    Postdoctoral Scholar – Tumor Immunology

    Moffit Cancer Center – Tampa Bay, Florida, United States

    > See All Jobs

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