| Vol. 14.10 – 18 March, 2022 |
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| Researchers showed that type 1 interferon regulated coinhibitory receptor expression on human T cells, inducing PD-1/TIM-3/LAG-3 while inhibiting T cell immunoreceptor with immunoglobulin and ITIM domains expression. [Nature Immunology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators reported the development and deployment of Bacterioboat, which consisted of surface-encapsulated mesoporous nanoparticles on metabolically active Lactobacillus reuteri as a drug carrier suitable for oral administration. [Science Advances] |
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| Thr authors explored the effect of Autophagy-related 5 (Atg5) deficiency in liver CD11c+ cells in mice fed high-fat diet. When compared to control mice, Atg5-deficient CD11c+ mice exhibited increased glucose intolerance and decreased insulin sensitivity when fed a HFD. [Nature Communications] |
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| Scientists showed that B cell responses remained T cell dependent in constitutive Wiskott-Aldrich syndrome protein (WASp)-deficient mice, whereas selective WASp deletion in germinal center B cells was sufficient to induce broad development of self-reactive antibodies and kidney pathology. [Cell Reports] |
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| Investigators characterized the immune phenotype of aged CD4+ T cells in the lacrimal gland as compared with lymphoid organs. Effector T helper 1 genes were highly upregulated on aged Tregs, including the master regulator Tbx21. [GeroScience] |
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| Using two chimeric mouse models, scientists demonstrated that the replacement of mutant LRRK2 with wild-type formed of the protein in T- and B-lymphocytes diminished LPS-mediated inflammation and rescued the substantia nigra pars compacta dopamine neuron loss in the mutant LRRK2 brain. [npj Parkinsons Disease] |
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| Researchers developed a rapid semi-quantitative method for in situ imaging of bacteria and multiplex cell phenotypes on the same solid tumor tissue sections. [Cytometry Part A] |
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| Drosophila larvae exposed to benzene were examined for total hemocyte count, phagocytic activity, oxidative stress, apoptosis, and their developmental delay and reduction were analyzed. [Environmental Toxicology] |
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| The authors showed that branching of asparagine-linked glycans increased with age in females more than in males, in naive T cells more than in memory T cells, and in CD4+ more than in CD8+ T cells. [Nature Aging] |
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| Investigators highlight microplastics’ and nanoplastics’ pathways to the food chains and how these plastic particles can cause risks to human health [Chemosphere] |
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| Diagnosis of Pprimary immune regulatory disorders is a significant challenge to physicians due to their rarity, complexity, and diversity in clinical manifestations. [Orphanet Journal of Rare Diseases] |
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| A German independent research institute, BioMed X, announced the start of its new research project ‘Regulatory T Cell Dysfunction in Autoimmunity and Inflammaging’ in collaboration with Merck KGaA, Darmstadt, Germany. [BioMedX] |
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| AbbVie announced Health Canada has approved SKYRIZI® for the treatment of adult patients with active psoriatic arthritis. In PsA, SKYRIZI can be used alone or in combination with a conventional non-biologic disease-modifying antirheumatic drug. [AbbVie] |
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| April 2 – April 3 Fukuoka, Japan and Virtual |
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| Princess Margaret Cancer Center – Toronto, Ontario, Canada |
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| NIH National Institute on Aging – Baltimore, Maryland, United States |
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| University of Sherbrooke – Sherbrooke, Quebec, Canada |
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| Lee Kong Chian School of Medicine – Singapore, Singapore |
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| Moffit Cancer Center – Tampa Bay, Florida, United States |
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