Immune Regulation News Volume 14.14 | Apr 22 2022

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    Danielle Corrigan
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    2022-04-22 | IRN 14.14


    Immune Regulation News by STEMCELL Technologies
    Vol. 14.14 – 22 April, 2022
    TOP
    STORY

    Augmenting NK Cell-Based Immunotherapy by Targeting
    Mitochondrial Apoptosis

    Scientists found that mitochondrial apoptosis pathway was essential for efficient NK killing, especially at
    physiologically relevant effector-to-target ratios.
    [Cell]

    AbstractGraphical
    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Vitamin E Enhances Cancer Immunotherapy by Reinvigorating
    Dendritic Cells via Targeting Checkpoint SHP1

    In mouse models, vitamin E (VitE) increased immune checkpoint therapy antitumor efficacy, which depended on dendritic
    cells (DCs). VitE entered DCs via SCARB1 receptor and restored tumor-associated DCs’ functionality by directly binding to and inhibiting protein tyrosine phosphatase SHP1.
    [Cancer Discovery]

    AbstractPress Release

    The IFNγ-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote
    Hypertension

    Investigators used mouse models of DOCA+salt treatment and adoptive transfer of CD8+ T cells (CD8T) from
    hypertensive animals to normotensive animals in in vivo studies.
    [Circulation Research]

    Abstract

    Binding of LAG-3 to Stable Peptide-MHC Class II Limits T Cell
    Function and Suppresses Autoimmunity and Anti-Cancer Immunity

    Researchers investigated the relative contribution of potential ligands, stable peptide-MHC class II complexes and
    fibrinogen-like protein 1, to lymphocyte activation gene-3 (LAG-3) activity in vitro and in vivo.
    [Immunity]

    AbstractGraphical
    Abstract

    The Mitochondrial Pyruvate Carrier Regulates Memory T Cell
    Differentiation and Antitumor Function

    The authors found that genetic deletion of mitochondrial pyruvate carrier (MPC) drove CD8+ T cell
    differentiation toward a memory phenotype. In the tumor microenvironment, MPC was essential for sustaining lactate oxidation to support CD8+ T cell antitumor function.
    [Cell Metabolism]

    Full ArticleGraphical Abstract

    PD-L1–PD-1 Interactions Limit Effector Regulatory T Cell
    Populations at Homeostasis and during Infection

    Investigators found that regulatory T cell with an effector phenotype (eTreg) cell expression of PD-1 acted as a sensor to
    rapidly tune the pool of eTreg cells at homeostasis and during inflammatory processes.
    [Nature Immunology]

    AbstractPress Release

    LAG3 Associates with TCR-CD3 Complexes and Suppresses Signaling
    by Driving Co-Receptor-Lck Dissociation

    Scientists showed that LAG3 moved to the immunological synapse and associated with the T cell receptor (TCR)-CD3 complex
    in CD4+ and CD8+ T cells, in the absence of binding to major histocompatibility complex class II — its canonical ligand.
    [Nature Immunology]

    AbstractPress Release

    Oncolytic Virus-Mediated Expansion of Dual-Specific CAR T Cells
    Improves Efficacy against Solid Tumors in Mice

    Using systemically delivered oncolytic viruses (OVs) and CAR T cells in immunocompetent mouse models, the authors defined
    a mechanism by which OVs could potentiate CAR T cell efficacy against solid tumor models of melanoma and glioma.
    [Science Translational Medicine]

    AbstractPress Release

    Tissue-Resident CD8+ T Cells Drive Compartmentalized
    and Chronic Autoimmune Damage against CNS Neurons

    Scientists observed that a high frequency of brain-infiltrating CD8+ T cells exhibited a memory T cells-like
    phenotype in human autoimmune encephalitis.
    [Science Translational Medicine]

    Abstract

    Myeloid Cell PKM2 Deletion Enhances Efferocytosis and Reduces
    Atherosclerosis

    Genetic deletion of pyruvate kinase muscle 2 (PKM2) in myeloid cells or limiting its nuclear translocation reduced
    atherosclerosis by suppressing inflammation and enhancing efferocytosis.
    [Circulation Research]

    AbstractFull
    Article    Graphical Abstract

    Human Coronary Plaque T Cells Are Clonal and Cross-React to
    Virus and Self

    Researchers used single-cell technology and in vitro assays to interrogate the immune microenvironment of human
    coronary atherosclerotic plaque at different stages of maturity.
    [Circulation Research]

    AbstractGraphical
    Abstract

    A Common Framework of Monocyte-Derived Macrophage
    Activation

    The authors contextualized macrophage heterogeneity across mouse tissues and inflammatory conditions, specifically aiming
    to define a common framework of macrophage activation.
    [Science Immunology]

    Full Article

    Androgen Conspires with the CD8+ T Cell Exhaustion
    Program and Contributes to Sex Bias in Cancer

    Investigators established a role for CD8+ T cell-dependent anti-tumor immunity in mediating sex differences in
    tumor aggressiveness, which was driven by the gonadal androgen but not sex chromosomes.
    [Science Immunology]

    AbstractPress Release

    Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.
    REVIEWS

    A Guide to Antigen Processing and Presentation

    Scientists describe the essentials of antigen processing and presentation and how the source proteins for these antigens
    are tagged for degradation, destroyed and ultimately displayed as peptides in complex with major histocompatibility complex molecules for T cell recognition.
    [Nature Reviews Immunology]

    Full Article

    Cellular Metabolic Adaptations in Rheumatoid Arthritis and
    Their Therapeutic Implications

    Understanding the complex interplay between metabolic and inflammatory pathways in synovial cells in rheumatoid arthritis
    will provide insight into the underlying mechanisms of disease pathogenesis.
    [Nature Reviews Rheumatology]

    Abstract

    CD36, a Signaling Receptor and Fatty Acid Transporter That
    Regulates Immune Cell Metabolism and Fate

    The authors examine the dual functions of CD36 in a variety of immune cells, especially macrophages and T
    cells.
    [Journal of Experimental Medicine]

    Full Article

    INDUSTRY AND POLICY
    NEWS

    Dragonfly Therapeutics Announces Multi-Target Expansion of Its
    Research Collaboration with AbbVie to Develop Novel Therapeutic Candidates for Immune-Mediated Diseases

    Dragonfly Therapeutics, Inc. announced an expansion of its research collaboration with AbbVie to discover and develop
    Dragonfly’s novel immunotherapies for new targets in autoimmune and fibrotic diseases.
    [Dragonfly Therapeutics, Inc. (Cision US, Inc.)]

    Press Release

    FEATURED EVENT

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    Discovery – From Chemical Biology to Therapeutics

    May 22 – 25, 2022
    Denver, Colorado, United States

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Translational
    Autoimmunity

    Uppsala University – Uppsala, Sweden

    Research
    Technician – Human Biology

    Fred Hutchinson Cancer Center – Seattle, Washington, United States

    Research
    Associate – Molecular Biology

    The University of British Columbia – Vancouver, British Columbia, Canada

    PhD
    Position – Tumor Immunology

    University Hospital Carl Gustav Carus Dresden – Dresden, Germany

    Postdoctoral
    Fellow/Assistant Staff Scientist – Metabolic Regulation of Innate-Like T cells

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    > See All Jobs

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