Immune Regulation News Volume 14.17 | May 13 2022

May 13, 2022

155

2022-05-13 | IRN 14.17

Immune Regulation News by STEMCELL Technologies

Vol. 14.17 – 13 May, 2022

TOP STORY

Single-Cell eQTL Models Reveal Dynamic T Cell State Dependence of Disease Loci

Using more than 500,000 unstimulated memory T cells from 259 Peruvian individuals, scientists showed that around one-third of 6,511 cis-expression quantitative trait loci (eQTLs) had effects that were mediated by continuous multimodally defined cell states, such as cytotoxicity and regulatory capacity.
[Nature]

Abstract

Find the Right Antibodies for Your Stem Cell Research. Learn More

PUBLICATIONSRanked by the impact factor of the journal

Reversible CD8 T Cell–Neuron Cross-Talk Causes Aging-Dependent Neuronal Regenerative Decline

Researchers identified an aging-dependent mechanism that relied on the CXCL13-dependent recruitment and activation of CXCR5⁺CD8⁺ T cells in proximity to sensory neurons that restricted axonal regeneration after nerve injury after communication with MHC I–presenting dorsal root ganglia neurons.
[Science]

Abstract Graphical Abstract

Rapid, Site-Specific Labeling of “Off-the-Shelf” and Native Serum Autoantibodies with T Cell–Redirecting Domains

Investigators developed a simple method to site-specifically and covalently attach a T cell–redirecting domain to any off-the-shelf, human immunoglobulin G (IgG) or native IgG isolated from serum.
[Science Advances]

Full Article

The Immune Checkpoint B7x Expands Tumor-Infiltrating Tregs and Promotes Resistance to Anti-CTLA-4 Therapy

The authors showed that transduction and stable expression of B7x in multiple syngeneic tumor models led to the expansion of immunosuppressive Tregs.
[Nature Communications]

Full Article

Hypoxia Induces Adrenomedullin from Lung Epithelia, Stimulating ILC2 Inflammation and Immunity

Researchers reported that conditional deletion of the E3 ubiquitin ligase VHL in lung epithelial cells resulted in exacerbated type 2 responses accompanied by selective increase of group 2 innate lymphoid cells (ILC2s) at steady state and following inflammation or helminth infection.
[Journal of Experimental Medicine]

Abstract Press Release

LAMP2 Regulates Autophagy in the Thymic Epithelium and Thymic Stroma-Dependent CD4 T Cell Development

Scientists showed that lysosomal-associated membrane protein 2 (LAMP2) was highly expressed in cortical thymic epithelial cells and that genetic inactivation of Lamp2 in thymic stromal cells impaired the development of CD4 T cells that completed positive selection.
[Autophagy]

Full Article

Mobilization of Innate and Adaptive Antitumor Immune Responses by the RNP-Targeting Antibody ATRC-101

In syngeneic murine models, ATRC-101 demonstrated robust antitumor activity and evidence of immune memory following rechallenge of cured mice with fresh tumor cells.
[Proceedings of the National Academy of Sciences of the United States of America]

Full Article Press Release

The Kinase p38α Functions in Dendritic Cells to Regulate Th2-Cell Differentiation and Allergic Inflammation

The authors showed that p38α activity in dendritic cells was decreased upon house dust mite stimulation and dynamically regulated by both extrinsic signals and T helper 2 (Th2)-instructive cytokines.
[Cellular & Molecular Immunology]

Full Article

Aryl Hydrocarbon Receptor Signals in Epithelial Cells Govern the Recruitment and Location of Helios⁺ Tregs in the Gut

Scientists administered indigo naturalis (IN), a nontoxic phytochemical aryl hydrocarbon receptor agonist used for treating patients with ulcerative colitis in Asia, and showed that IN increased Helios⁺ Tregs and MHC class II⁺ epithelial cells in the colon.
[Cell Reports]

Full Article Graphical Abstract

HOIL1 Regulates Group 2 Innate Lymphoid Cell Numbers and Type 2 Inflammation in the Small Intestine

To investigate the role of HOIL1 in regulating intestinal inflammation, researchers employed a mouse model of partial HOIL1 deficiency.
[Mucosal Immunology]

Full Article

Tim-3⁺ Decidual Mφs Induced Th2 and Treg Bias in Decidual CD4⁺ T Cells and Promoted Pregnancy Maintenance via CD132

Investigators found a higher frequency of T cell immunoglobulin mucin-3 (Tim-3)⁺ decidual macrophages (Mφs) in response to trophoblasts. The reduced abundance of Tim-3 on Mφs was accompanied by disordered anti- and pro-inflammatory cytokine profiles in miscarriage.
[Cell Death & Disease]

Full Article

**Human CD4⁺/CD8α⁺ Regulatory T Cells Induced by Faecalibacterium prausnitzii Protect against Intestinal Inflammation**

Scientists demonstrated a protective effect of an HLA-DR*0401-restricted DP8α Treg clone combined with F. prausnitzii administration in a colitis model.
[JCI Insight]

Abstract Full Article Graphical Abstract

Maternal-Fetal Conflict Averted by Progesterone Induced FOXP3⁺ Regulatory T Cells

The authors showed that the female reproductive hormone, progesterone, coordinated immune tolerance by stimulating the expansion of FOXP3⁺ regulatory T cells.
[iScience]

Abstract Full Article Graphical Abstract

REVIEWS

Macrophage Functional Diversity in NAFLD — More than Inflammation

Scientists reveal hepatic macrophage function beyond their classically described inflammatory role in the progression of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis pathogenesis.
[Nature Reviews Endocrinology]

Abstract

**Thymic and Extrathymic Aire-Expressing Cells in Maternal-Fetal Tolerance**

Investigators summarize findings related to essential Aire biology, discuss the known roles of Aire-deficiency related to pregnancy complications and infertility, and review the newly discovered role for extrathymic Aire-expressing cells (eTACs) in the maintenance of maternal-fetal tolerance.
[Immunological Reviews]

Abstract

Therapeutic Opportunities to Modulate Immune Tolerance through the Metabolism-Chromatin Axis

The authors evaluate novel possibilities for developing therapeutic strategies to modulate immune tolerance through metabolism via epigenetic drugs.
[Trends in Endocrinology and Metabolism]

Abstract

INDUSTRY AND POLICY NEWS

NexImmune, Yale, and JDRF Enter into Research Partnership for Type 1 Diabetes

NexImmune, Inc., Yale, and JDRF have begun a two-year project to explore the use of NexImmune’s AIM nanoparticles in combination with an anti-CD3 mAb to tolerize, deplete or modulate diabetes antigen-specific T cells.
[NexImmune, Inc.]

Press Release

NGM Bio Announces Initiation of Phase I/Ib Clinical Study of NGM438 for the Treatment of Patients with Advanced Solid Tumors

NGM Biopharmaceuticals, Inc. announced it has initiated a Phase I/Ib clinical study of NGM438 for the treatment of patients with advanced solid tumors.
[NGM Biopharmaceuticals, Inc.]

Press Release

FEATURED EVENT

Immune Regulation News Volume 14.17 | May 13 2022

Single-Cell eQTL Models Reveal Dynamic T Cell State Dependence of Disease Loci

Reversible CD8 T Cell–Neuron Cross-Talk Causes Aging-Dependent Neuronal Regenerative Decline

Rapid, Site-Specific Labeling of “Off-the-Shelf” and Native Serum Autoantibodies with T Cell–Redirecting Domains

The Immune Checkpoint B7x Expands Tumor-Infiltrating Tregs and Promotes Resistance to Anti-CTLA-4 Therapy

Hypoxia Induces Adrenomedullin from Lung Epithelia, Stimulating ILC2 Inflammation and Immunity

LAMP2 Regulates Autophagy in the Thymic Epithelium and Thymic Stroma-Dependent CD4 T Cell Development

Mobilization of Innate and Adaptive Antitumor Immune Responses by the RNP-Targeting Antibody ATRC-101

The Kinase p38α Functions in Dendritic Cells to Regulate Th2-Cell Differentiation and Allergic Inflammation

Aryl Hydrocarbon Receptor Signals in Epithelial Cells Govern the Recruitment and Location of Helios⁺ Tregs in the Gut

HOIL1 Regulates Group 2 Innate Lymphoid Cell Numbers and Type 2 Inflammation in the Small Intestine

Tim-3⁺ Decidual Mφs Induced Th2 and Treg Bias in Decidual CD4⁺ T Cells and Promoted Pregnancy Maintenance via CD132

**Human CD4⁺/CD8α⁺ Regulatory T Cells Induced by Faecalibacterium prausnitzii Protect against Intestinal Inflammation**

Maternal-Fetal Conflict Averted by Progesterone Induced FOXP3⁺ Regulatory T Cells

Macrophage Functional Diversity in NAFLD — More than Inflammation

**Thymic and Extrathymic Aire-Expressing Cells in Maternal-Fetal Tolerance**

Therapeutic Opportunities to Modulate Immune Tolerance through the Metabolism-Chromatin Axis

NexImmune, Yale, and JDRF Enter into Research Partnership for Type 1 Diabetes

NGM Bio Announces Initiation of Phase I/Ib Clinical Study of NGM438 for the Treatment of Patients with Advanced Solid Tumors

ISSCR 2022 Annual Meeting

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Research Technologist – Bioengineering

Postdoctoral Fellow – Stromal Immune Interactions in Cancer

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Single-Cell eQTL Models Reveal Dynamic T Cell State Dependence of Disease Loci

Reversible CD8 T Cell–Neuron Cross-Talk Causes Aging-Dependent Neuronal Regenerative Decline

Rapid, Site-Specific Labeling of “Off-the-Shelf” and Native Serum Autoantibodies with T Cell–Redirecting Domains

The Immune Checkpoint B7x Expands Tumor-Infiltrating Tregs and Promotes Resistance to Anti-CTLA-4 Therapy

Hypoxia Induces Adrenomedullin from Lung Epithelia, Stimulating ILC2 Inflammation and Immunity

LAMP2 Regulates Autophagy in the Thymic Epithelium and Thymic Stroma-Dependent CD4 T Cell Development

Mobilization of Innate and Adaptive Antitumor Immune Responses by the RNP-Targeting Antibody ATRC-101

The Kinase p38α Functions in Dendritic Cells to Regulate Th2-Cell Differentiation and Allergic Inflammation

Aryl Hydrocarbon Receptor Signals in Epithelial Cells Govern the Recruitment and Location of Helios+ Tregs in the Gut

HOIL1 Regulates Group 2 Innate Lymphoid Cell Numbers and Type 2 Inflammation in the Small Intestine

Tim-3+ Decidual Mφs Induced Th2 and Treg Bias in Decidual CD4+ T Cells and Promoted Pregnancy Maintenance via CD132

Human CD4+/CD8α+ Regulatory T Cells Induced by Faecalibacterium prausnitzii Protect against Intestinal Inflammation

Maternal-Fetal Conflict Averted by Progesterone Induced FOXP3+ Regulatory T Cells

Macrophage Functional Diversity in NAFLD — More than Inflammation

Thymic and Extrathymic Aire-Expressing Cells in Maternal-Fetal Tolerance

Therapeutic Opportunities to Modulate Immune Tolerance through the Metabolism-Chromatin Axis

NexImmune, Yale, and JDRF Enter into Research Partnership for Type 1 Diabetes

NGM Bio Announces Initiation of Phase I/Ib Clinical Study of NGM438 for the Treatment of Patients with Advanced Solid Tumors

Aryl Hydrocarbon Receptor Signals in Epithelial Cells Govern the Recruitment and Location of Helios⁺ Tregs in the Gut

Tim-3⁺ Decidual Mφs Induced Th2 and Treg Bias in Decidual CD4⁺ T Cells and Promoted Pregnancy Maintenance via CD132

**Human CD4⁺/CD8α⁺ Regulatory T Cells Induced by Faecalibacterium prausnitzii Protect against Intestinal Inflammation**

Maternal-Fetal Conflict Averted by Progesterone Induced FOXP3⁺ Regulatory T Cells

**Thymic and Extrathymic Aire-Expressing Cells in Maternal-Fetal Tolerance**