Immune Regulation News Volume 14.18 | May 20 2022

May 20, 2022

2022-05-20 | IRN 14.18

Immune Regulation News by STEMCELL Technologies

Vol. 14.18 – 20 May, 2022

TOP STORY

Activation of the Transcription Factor NRF2 Mediates the Anti-Inflammatory Properties of a Subset of Over-the-Counter and Prescription NSAIDs

Using genetic and pharmacologic approaches, the authors found that nonsteroidal anti-inflammatory drug (NSAID)-mediated GDF15 induction was dependent on the activation of nuclear factor erythroid 2-related factor 2 (NRF2) in myeloid cells.
[Immunity]

Abstract Graphical Abstract

Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.

PUBLICATIONSRanked by the impact factor of the journal

Zbtb20 Identifies and Controls a Thymus-Derived Population of Regulatory T Cells That Play a Role in Intestinal Homeostasis

Zbtb20 expression identified and controlled the function of a distinct subset of Tregs that were involved in intestinal homeostasis.
[Science Immunology]

Abstract Press Release

The Phosphatase PTEN Links Platelets with Immune Regulatory Functions of Mouse T Follicular Helper Cells

Investigators showed that mice with platelet-specific deletion of phosphatase and tensin homolog (Pten) developed age-related lymphoproliferative diseases and humoral autoimmunity not seen in wildtype animals.
[Nature Communications]

Full Article

The Ubiquitin Ligase Cul5 Regulates CD4⁺ T Cell Fate Choice and Allergic Inflammation

Researchers showed that the E3 ubiquitin ligase Cul5 determined fate selection in CD4⁺ T cells by regulating IL-4 receptor signaling.
[Nature Communications]

Full Article

ATP Spreads Inflammation to Other Limbs through Crosstalk between Sensory Neurons and Interneurons

The authors showed that ATP served as both a neurotransmitter and an inflammation enhancer, thus acting as an intermediary between the local inflammation and neural pathway that induced inflammation on the other side.
[Journal of Experimental Medicine]

Abstract Press Release

Claudin-12 Deficiency Inhibits Tumor Growth by Impairing Transendothelial Migration of Myeloid-Derived Suppressor Cells

Scientists used mice deficient in tight-junction protein Claudin-12 (Cldn12) compared to wild-type mice and found that loss of host Cldn12 inhibited the growth of transplanted tumors, reduced intratumoral accumulation of myeloid-derived suppressor cells, increased anti-tumor immune responses, and decreased tumor vescular density.
[Cancer Research]

Abstract

Insights into Immune Escape during Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer

Investigators showed that Nitroso-N-methylurea–induced mammary tumors in outbred Sprague-Dawley rats recapitulated the heterogeneity for mutational profiles, ER expression, and immune evasive mechanisms observed in human breast cancer.
[Cancer Immunology Research]

Full Article

Retinoic Acid Signaling Acts as a Rheostat to Balance Treg Function

Researchers employed mouse models in which retinoic acid (RA) signaling was silenced by the expression of the dominant negative receptor RARα in all T cells.
[Cellular & Molecular Immunology]

Abstract

WEE1 Inhibition Enhances the Antitumor Immune Response to PD-L1 Blockade by the Concomitant Activation of STING and STAT1 Pathways in SCLC

The authors demonstrated cell-autonomous and immune-stimulating activity of WEE1 inhibition in small cell lung cancer (SCLC) models.
[Cell Reports]

Full Article Graphical Abstract

Myeloid Cell-Specific Topoisomerase 1 Inhibition Using DNA Origami Mitigates Neuroinflammation

Investigators showed that topoisomerase 1 (TOP1) was highly expressed in neuroinflammatory conditions, and TOP1 inhibition using camptothecin and its FDA-approved analog topotecan reduced inflammatory responses in microglia/macrophages and ameliorated neuroinflammation in vivo.
[EMBO Reports]

Full Article Graphical Abstract

Recruitment of Monocytes Primed to Express Heme Oxygenase-1 Ameliorates Pathological Lung Inflammation in Cystic Fibrosis

Scientists revealed the mechanism of action of PP-007 responsible for the immunomodulatory function observed in clinical trials for a wide range of diseases and demonstrated the potential use of PP-007 in controlling neutrophilic pulmonary inflammation by promoting the expression of HO-1 in monocytes/macrophages.
[Experimental & Molecular Medicine]

Full Article

Variants of Beta-Glucan Polysaccharides Downregulate Autoimmune Inflammation

Researchers investigated the effects of β-glucan polysaccharides in the effector phase of arthritis and as regulators of psoriasis and psoriatic arthritis-like symptoms in mice.
[Communications Biology]

Full Article

Peripheral NOD-Like Receptor Deficient Inflammatory Macrophages Trigger Neutrophil Infiltration into the Brain Disrupting Daytime Locomotion

Scientists investigated whether inappropriate macrophage-evoked inflammation altered central nervous system control of daily-life animal locomotion using a set of zebrafish mutants selected for specific macrophage dysfunction and microglia deficiency.
[Communications Biology]

Full Article

Learn about immunological considerations for hPSC banking by watching Dr. David Turner's webinar from the Nature Research Round Table on hPSC Quality

REVIEWS

Immunosuppressive Cells in Cancer: Mechanisms and Potential Therapeutic Targets

The authors summarize the phenotype, function, and potential therapeutic targets of immunosuppressive cells in the tumor microenvironment.
[Journal of Hematology & Oncology]

Full Article

Crosstalk between ILC2s and Th2 CD4⁺ T Cells in Lung Disease

Scientists review the latest progress on type 2 innate lymphoid cells (ILC2s) and CD4⁺T cells in the lung, the close relationship between the two, and their relevance in the lung disease and immunity.
[Journal of Immunology Research]

Full Article

INDUSTRY AND POLICY NEWS

Surrozen Initiates Dosing in Phase I Clinical Trial of SZN-1326 for Moderate to Severe Ulcerative Colitis

Surrozen, Inc. announced that the first subject has been dosed in its three-part Phase I clinical trial to evaluate SZN-1326 for the potential treatment of moderate to severe ulcerative colitis.
[Surrozen, Inc.]

Press Release

Research Animals Mistreated by Leading Supplier, Animal Welfare Group Alleges

The contract research organization Inotiv is neglecting animals at a research facility in Indiana that conducts toxicity testing of experimental drugs, the Humane Society of the United States alleged.
[ScienceInsider]

Press Release

FEATURED EVENT

Immune Regulation News Volume 14.18 | May 20 2022

Activation of the Transcription Factor NRF2 Mediates the Anti-Inflammatory Properties of a Subset of Over-the-Counter and Prescription NSAIDs

Zbtb20 Identifies and Controls a Thymus-Derived Population of Regulatory T Cells That Play a Role in Intestinal Homeostasis

The Phosphatase PTEN Links Platelets with Immune Regulatory Functions of Mouse T Follicular Helper Cells

The Ubiquitin Ligase Cul5 Regulates CD4⁺ T Cell Fate Choice and Allergic Inflammation

ATP Spreads Inflammation to Other Limbs through Crosstalk between Sensory Neurons and Interneurons

Claudin-12 Deficiency Inhibits Tumor Growth by Impairing Transendothelial Migration of Myeloid-Derived Suppressor Cells

Insights into Immune Escape during Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer

Retinoic Acid Signaling Acts as a Rheostat to Balance Treg Function

WEE1 Inhibition Enhances the Antitumor Immune Response to PD-L1 Blockade by the Concomitant Activation of STING and STAT1 Pathways in SCLC

Myeloid Cell-Specific Topoisomerase 1 Inhibition Using DNA Origami Mitigates Neuroinflammation

Recruitment of Monocytes Primed to Express Heme Oxygenase-1 Ameliorates Pathological Lung Inflammation in Cystic Fibrosis

Variants of Beta-Glucan Polysaccharides Downregulate Autoimmune Inflammation

Peripheral NOD-Like Receptor Deficient Inflammatory Macrophages Trigger Neutrophil Infiltration into the Brain Disrupting Daytime Locomotion

Immunosuppressive Cells in Cancer: Mechanisms and Potential Therapeutic Targets

Crosstalk between ILC2s and Th2 CD4⁺ T Cells in Lung Disease

Surrozen Initiates Dosing in Phase I Clinical Trial of SZN-1326 for Moderate to Severe Ulcerative Colitis

Research Animals Mistreated by Leading Supplier, Animal Welfare Group Alleges

Recent Insights Into Immuno-Oncology

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Postdoctoral Scholarship – Immunology

Postdoctoral Research Scientist – B Cell Immunology

Research Technologist – Bioengineering

Postdoctoral Fellow – Stromal Immune Interactions in Cancer

Tenure Track Faculty Position – Cell Signaling

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Activation of the Transcription Factor NRF2 Mediates the Anti-Inflammatory Properties of a Subset of Over-the-Counter and Prescription NSAIDs

Zbtb20 Identifies and Controls a Thymus-Derived Population of Regulatory T Cells That Play a Role in Intestinal Homeostasis

The Phosphatase PTEN Links Platelets with Immune Regulatory Functions of Mouse T Follicular Helper Cells

The Ubiquitin Ligase Cul5 Regulates CD4+ T Cell Fate Choice and Allergic Inflammation

ATP Spreads Inflammation to Other Limbs through Crosstalk between Sensory Neurons and Interneurons

Claudin-12 Deficiency Inhibits Tumor Growth by Impairing Transendothelial Migration of Myeloid-Derived Suppressor Cells

Insights into Immune Escape during Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer

Retinoic Acid Signaling Acts as a Rheostat to Balance Treg Function

WEE1 Inhibition Enhances the Antitumor Immune Response to PD-L1 Blockade by the Concomitant Activation of STING and STAT1 Pathways in SCLC

Myeloid Cell-Specific Topoisomerase 1 Inhibition Using DNA Origami Mitigates Neuroinflammation

Recruitment of Monocytes Primed to Express Heme Oxygenase-1 Ameliorates Pathological Lung Inflammation in Cystic Fibrosis

Variants of Beta-Glucan Polysaccharides Downregulate Autoimmune Inflammation

Peripheral NOD-Like Receptor Deficient Inflammatory Macrophages Trigger Neutrophil Infiltration into the Brain Disrupting Daytime Locomotion

Immunosuppressive Cells in Cancer: Mechanisms and Potential Therapeutic Targets

Crosstalk between ILC2s and Th2 CD4+ T Cells in Lung Disease

Surrozen Initiates Dosing in Phase I Clinical Trial of SZN-1326 for Moderate to Severe Ulcerative Colitis

Research Animals Mistreated by Leading Supplier, Animal Welfare Group Alleges

The Ubiquitin Ligase Cul5 Regulates CD4⁺ T Cell Fate Choice and Allergic Inflammation

Crosstalk between ILC2s and Th2 CD4⁺ T Cells in Lung Disease