 | | Vol. 14.19 – 27 May, 2022 |
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| Researchers revealed a precisely timed process in distinct anatomical niches for the establishment of macrophage subsets in the central nervous system (CNS).
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| In a mouse model of excisional skin wounding, inhibition or loss of SLC7A11 expression accelerated healing dynamics and reduced the apoptotic cell load in the wound. Mechanistic studies revealed a link between SLC7A11, glucose homeostasis, and diabetes.
[Nature] |
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| Scientists demonstrated that major histocompatibility class I (MHC-I) cross-dressing, an antigen presentation pathway in which dendritic cells acquired and displayed intact tumor-derived peptide:MHC-I molecules, was important in orchestrating anti-tumor immunity.
[Immunity] |
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| The authors identified brain interleukin 2 levels as a limiting factor for brain-resident Treg cells. They developed a gene-delivery approach for astrocytes, with a small-molecule on-switch to allow temporal control, and enhanced production in reactive astrocytes to spatially direct delivery to inflammatory sites.
[Nature Immunology] |
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| Investigators provided mechanistic insights as to how distinct T cell fate trajectories could be established during the first division.
[Molecular Cell] |
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| Researchers demonstrated that the genomic landscape shaped by surgical resection created an immunosuppressive milieu characterized by hypoxia and high-influx of myeloid cells, fostering cancer progression and hindering PD-L1 blockade therapy.
[Nature Communications] |
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| Scientists revealed that chondroitin sulfate proteoglycans played a critical role in preventing inflammation resolution by blocking the conversion of pro-inflammatory immune cells to a pro-repair phenotype in rodent models of spinal cord injury.
[Nature Communications] |
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| Investigators showed double positive T cells in murine and human tumors as a heterogenous population originating from single positive T cells which re-expressed the opposite co-receptor and acquired features of the opposite cell type’s phenotype and function following T cell receptor stimulation.
[Journal of Experimental Medicine] |
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| Using a functional genetic knockdown screen, the authors identified the long noncoding RNA Malat1 as a regulator of terminal effector cells and the terminal effector memory circulating memory subset.
[Journal of Experimental Medicine] |
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| Scientists showed for the first time that toll-like receptor 9−/− mice exhibited a low bone mass and low-grade systemic chronic inflammation, which was characterized by the expansion of CD4+ T cells and increased levels of inflammatory cytokines, including TNFα, RANKL, and IL1β.
[Bone Research] |
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| Glioma isocitrate dehydrogenase type 1 (IDH) mutations resulted in specifically educated, dysfunctional dendritic cells via paracrine reprogramming of infiltrating monocytes, providing the basis for combinatorial immunotherapy concepts against IDH mutant gliomas.
[Neuro-Oncology] |
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| Researchers tested the impact of hepatocyte-derived free mitochondria on blood-derived and lung-derived CD8 T cells in vitro and in experimental mouse models in vivo.
[Thorax] |
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| Inducible depletion of γδ T cells showed that direct interaction between γδ T cells and immature B cells in the spleen supported an “innate” transition to mature B cells with a broad range of antigen specificities.
[Cell Reports] |
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| The authors discuss the origins of mast cells and their diverse and plastic phenotypes that are influenced by tissue residence.
[Nature Reviews Immunology] |
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| Scientists review foundational technologies to profile the epigenome at multiple scales, including mapping the locations of transcription factors and histone modifications, DNA methylation and 3D genome conformation.
[Nature Immunology] |
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| LIGHT and its signaling receptors, herpesvirus entry mediator, and lymphotoxin β receptor form an immune regulatory network with two co-receptors of herpesvirus entry mediator, checkpoint inhibitor B and T lymphocyte attenuator, and CD160.
[Journal of Experimental Medicine] |
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| Quoin Pharmaceuticals Ltd. announced it has signed a second, exclusive research agreement with the Queensland University of Technology, Australia that will focus on investigating small-molecule inhibition of the VCAM-1: VL-4 interaction for the treatment of scleroderma, a rare, autoimmune disease.
[Quoin Pharmaceuticals, Ltd.] |
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| DxTerity Diagnostics announced the opening of enrollment in Empower Lupus Erythematous Patients Via Allowing RemoTe Evaluation (ELEVATE), a new observational clinical study for patients with Systemic Lupus Erythematosus.
[DxTerity Diagnostics (Cision US, Inc.)] |
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| June 17 – 20, 2022
Halifax, Nova Scotia, Canada |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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| | Van Andel Institute – Grand Rapids, Michigan, United States |
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| | National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States |
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| | The Ohio State University – Columbus, Ohio, United States |
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| | Karolinska Institute – Stockholm, Sweden |
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