Immune Regulation News Volume 14.20 | Jun 3 2022

    By
    lbeveridge
    -
    0
    172







    2022-06-03 | IRN 14.20


    Immune Regulation News by STEMCELL Technologies
    Vol. 14.20 – 3 June, 2022
    TOP STORY

    Brain Motor and Fear Circuits Regulate Leukocytes during Acute Stress

    Scientists showed that distinct brain regions shaped leukocyte distribution and function throughout the body during acute stress in mice.
    [Nature]

    AbstractPress Release
    ON903-COVID-19 Digital Resources 728 x 90
    PUBLICATIONSRanked by the impact factor of the journal

    The CD8α–PILRα Interaction Maintains CD8+ T Cell Quiescence

    Investigators showed that CD8α was critical for the maintenance of CD8+ T cells in a physiologically quiescent state in peripheral lymphoid organs.
    [Science]

    AbstractPress Release

    Cancer Immunotherapy Based on Image-Guided STING Activation by Nucleotide Nanocomplex-Decorated Ultrasound Microbubbles

    Scientists developed an ultrasound-guided cancer immunotherapy platform using nanocomplexes composed of 2′3′-cyclic guanosine monophosphate-adenosine monophosphate electrostatically bound to biocompatible branched cationic biopolymers that are conjugated onto antigen-presenting cell-targeting microbubbles.
    [Nature Nanotechnology]

    AbstractPress Release

    Single-Cell RNA Sequencing Reveals Evolution of Immune Landscape during Glioblastoma Progression

    Using single-cell transcriptomics and flow cytometry, investigators unveiled large-scale comprehensive longitudinal changes in immune cell composition throughout tumor progression in an epidermal growth factor receptor-driven genetic mouse glioblastoma model.
    [Nature Immunology]

    Full Article

    Type 2 Cytokines in the Thymus Activate Sirpα+ Dendritic Cells to Promote Clonal Deletion

    In an effort to eliminate SIRPα+ classic dendritic cell 2 subsets, researchers discovered that a substantial proportion expressed the surface lectin, CD301b, in the thymus.
    [Nature Immunology]

    Abstract

    Rgs16 Promotes Antitumor CD8+ T Cell Exhaustion

    By performing lineage tracing using reporter mice in which mCherry marked Rgs16-expressing cells, the authors identified that Rgs16+CD8+ tumor-infiltrating lymphocytes were terminally differentiated, expressed low levels of T cell factor 1, and underwent apoptosis as early as six days after the onset of Rgs16 expression.
    [Science Immunology]

    Abstract

    Persistent CAD Activity in Memory CD8+ T Cells Supports rRNA Synthesis and Ribosomal Biogenesis Required at Rechallenge

    Scientists identified a role for the initial and continued activation of the trifunctional rate-limiting enzyme of the de novo pyrimidine synthesis pathway CAD (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase) as critical in promoting the rapid recall response of previously activated CD8+ T cells.
    [Science Immunology]

    Abstract

    Amelioration of Systemic Antitumor Immune Responses in Cocktail Therapy by Immunomodulatory Nanozymes

    To overcome the bottlenecks of single-mode nanozymes, including “off-target” toxicity and ineffectiveness toward metastatic cancers, researchers designed magnetic nanoparticle-based multifunctional visualized immunomodulatory nanozymes.
    [Science Advances]

    Full Article

    Omega-3 Fatty Acid Epoxides Produced by PAF-AH2 in Mast Cells Regulate Pulmonary Vascular Remodeling

    The authors showed that ω-3 fatty acid-derived epoxides released from mast cells by PAF-AH2, an oxidized phospholipid-selective phospholipase A2, negatively regulated pulmonary hypertension.
    [Nature Communications]

    Full Article

    The Ube2m-Rbx1 Neddylation-Cullin-RING-Ligase Proteins Are Essential for the Maintenance of Regulatory T Cell Fitness

    Investigators showed that mice with Treg cell-specific deletion of Rbx1, a dual E3 for both neddylation and ubiquitylation by CRLs, developed an early-onset fatal inflammatory disorder, characterized by disrupted Treg cell homeostasis and suppressive functions.
    [Nature Communications]

    Full Article

    Corneal Tissue-Resident Memory T Cells Form a Unique Immune Compartment at the Ocular Surface

    The authors used intravital 2-photon microscopy to examine T cell responses in the cornea in mice. They showed that recruitment of CD8+ T cells in response to ocular virus infection resulted in the formation of tissue-resident memory T cells.
    [Cell Reports]

    Full ArticlePress ReleaseGraphical Abstract

    Mitochondrial Damage-Associated Molecular Patterns Trigger Arginase-Dependent Lymphocyte Immunoregulation

    Scientists described the lymphocyte response to damage-associated molecular patterns, including those of mitochondrial origin (mitoDAMPs). Using primary cells from mice and human donors, they demonstrated that NK cells and T cells adopted regulatory phenotypes and functions in response to mitoDAMPs.
    [Cell Reports]

    Full ArticleGraphical Abstract
    Cell Preparation For Crossmatch Assays
    REVIEWS

    Signaling Pathway(s) of TNFR2 Required for the Immunoregulatory Effect of CD4+Foxp3+ Regulatory T Cells

    The authors summarize and discuss the latest progress in the studies on the downstream signaling pathways of TNF-TNFR2 for controlling Treg homeostasis, differentiation and proliferation.
    [International Immunopharmacology]

    Press Release
    INDUSTRY AND POLICY NEWS

    After Oncology Wind-Down, TG’s Pivot to MS Faces Setback as FDA Pushes Approval Decision

    After winding down its oncology program to pivot to multiple sclerosis (MS), TG Therapeutics has suffered a fresh setback as its lead candidate faces an additional three-month wait for an FDA decision.
    [Fierce Biotech]

    Press Release

    Lupus Research Alliance and Lupus Therapeutics Response to Positive Data from Phase 2 Study on Potential First-in-class Lupus Treatment

    The Lupus Research Alliance and its clinical trial arm Lupus Therapeutics respond to Bristol Myers Squibb’s new positive results from a Phase II trial of its investigational agent deucravacitinib for the treatment of systemic lupus erythematosus
    [Lupus Research Alliance]

    Press Release
    FEATURED EVENT

    Biology of Acute Respiratory Infection

    September 11 – September 16, 2022
    Ventura, California, United States

    > See All Events

    JOB OPPORTUNITIES

    Researchers – Biology and Medicine

    China Medical University – Shenyang, China

    Postdoctoral Fellow – Human Genomics

    Human Technopole – Milan, Italy

    Postdoctoral Fellow – Immunology, Epigenetics, and Cellular Metabolism 

    Van Andel Institute – Grand Rapids, Michigan, United States

    Postdoctoral Fellow – Microenvironment and Signaling

    Albert Einstein College of Medicine – New York, New York, United States

    Director – Vaccine Research Center

    National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Immune Regulation News Twitter