 | | Vol. 14.23 – 24 June, 2022 |
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| Using Setx knock-in mice that carried the ALS4-causative L389S mutation, the authors described an immunological signature that consisted of clonally expanded, terminally differentiated effector memory CD8 T cells in the central nervous system and the blood of knock-in mice.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists discovered that the co-occupancy of TCF-1 and the architectural protein CTCF altered the structure of topologically associating domains in T cell progenitors, leading to interactions between previously insulated regulatory elements and target genes at late stages of T cell development.
[Nature Immunology] |
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| By using hair follicles (HFs) to study Treg cell–stem cell crosstalk, researchers showed an unrecognized function of the steroid hormone glucocorticoid in instructing skin-resident Treg cells to facilitate HF stem-cell activation and HF regeneration.
[Nature Immunology] |
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| The authors demonstrated that genetic ablation or therapeutic inhibition of the myeloid-specific hematopoietic cell kinase enabled the activity of antagonistic anti-programmed cell death protein 1, anti-CTLA4, or agonistic anti-CD40 immunotherapies in otherwise refractory tumors.
[Science Advances] |
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| Modulation of plasmacytoid dendritic cell versus conventional dendritic cell output from precursors by external factors may have allowed for adaptation of dendritic cell subset composition at later differentiation stages.
[Nature Communications] |
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| Scientists reported a catalytical nano-immunocomplex for precise and persistent sono-metabolic checkpoint trimodal cancer therapy, whose full activities were only triggered by sono-irradiation in tumor microenvironment.
[Nature Communications] |
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| Researchers determined whether a combination of Cowpea mosaic virus (CPMV) and anti-4-1BB monoclonal antibody agonist to stimulate tumor-resident and CPMV-recruited NK cells was an effective dual therapy approach to improve NK cell function and in situ cancer vaccination efficacy.
[Nano Letters] |
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| Investigators demonstrated that a lysine 4 histone H3 demethylase (KDM5A) impaired epithelial ovarian cancer infiltration by immune cells and inhibited antitumor immune responses.
[Cancer Immunology Research] |
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| The authors focused on the effects of lactate on Treg cells. In vitro, lactate improved Treg cell stability and function, whereas lactate degradation reduced Treg cell induction, increased antitumor immunity, and decreased tumor growth in mice.
[Cell Reports] |
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| Using a cereblon knockin mouse model that regained in vivo T cell response to lenalidomide, an immunomodulatory imide drug, scientists showed that lenalidomide reinstated the anti-tumor activity of CD28-deficient CD8+ T cells after programmed cell death protein 1 (PD-1) blockade.
[Cell Chemical Biology] |
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| Researchers examined a prime-boost strategy using a chimeric adenoviral vector that resisted pre-existing immunity followed by recombinant Listeria monocytogenes to amplify immunity to the gastrointestinal cancer antigen GUCY2C.
[NPJ Vaccines] |
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| Recent progress has increased our understanding of the cellular and pathophysiological roles of small ubiquitin-like modifiers (SUMO) modifications, extending their functions to the regulation of immunity, pluripotency, and nuclear body assembly in response to oxidative stress.
[Nature Reviews Molecular Cell Biology] |
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| The authors discuss the general pathophysiological concepts of IL-1-mediated autoinflammation, the epidemiological and clinical features of specific diseases, diagnostic challenges and approaches, and current and future perspectives for therapy.
[Nature Reviews Rheumatology] |
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| Investigators review the multifaceted roles of mitochondria during T cell differentiation, focusing on CD8+ cytotoxic T lymphocytes (CTLs) and consider how mitochondrial dysfunction can contribute to CTL exhaustion.
[Trends in Cell Biology] |
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| Mustang Bio, Inc. announced that the US FDA has granted Orphan Drug Designation to MB-106, Mustang’s CD20-targeted, autologous CAR T cell therapy for the treatment of Waldenstrom macroglobulinemia, a rare type of B-cell non-Hodgkin lymphoma.
[Mustang Bio, Inc.] |
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| Alladapt Immunotherapeutics has refilled the bank balance with $119 million in institutional financing from the likes of Novartis, which will be used to follow the biotech’s dream of developing the first FDA-approved therapy to treat the majority of food allergy patients.
[Fierce Biotech] |
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| September 19 – 20, 2022
Vejle, Denmark |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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| | National University of Ireland Galway – Galway, Ireland |
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| | Aarhus University – Aarhus, Denmark |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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