| Vol. 14.26 – 22 July, 2022 |
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| The authors profiled 80,000 T cells from 57 pancreatic ductal adenocarcinoma, 22 uninvolved/normal samples, and cultured tumor-infiltrating lymphocyte using single-cell transcriptomic and T cell receptor analysis. [Cancer Discovery] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Over half of intrahepatic cholangiocarcinoma (iCCA) displayed intratumoral heterogeneity of immune infiltration, and iCCA were classified into sparsely, heterogeneously, and highly infiltrated subgroups with distinct immunogenomic characteristics. [Cancer Discovery] |
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| Investigators present a novel, integrative approach in which 15-color multispectral imaging allows comprehensive cell classification based on multi-marker expression patterns. [Cell Metabolism] |
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| Flow cytometry and single-cell RNA sequencing of the lung tumors reveal that JHU083 increased CD8+ T cell and CD4+ Th1 cell infiltration, while EVax elicits robust Th1 cell-mediated immune responses and protects mice against EGFRL858R mutation-driven lung tumorigenesis. [Advanced Science] |
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| An acute graft-versus-host disease model (AGVHD) was established to observe the therapeutic effects of extracellular vesicles from mesenchymal stromal cell-derived human umbilical cords-arsenic trioxides on aGVHD. [Journal of Hematology & Oncology] |
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| The dual CDK12/CDK13 inhibitor ZSQ836 exerted potent anticancer activity in cell culture and mouse models and induced transcriptional reprogramming, including downregulation of DNA damage response genes. [Cancer Research] |
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| Wilms tumor 1-associating protein (WTAP) was upregulated in CD4+ T cells of tolerant kidney transplant recipients and positively correlated with Treg cell proportion. [Laboratory Investigation] |
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| 309 SLE-related genes were identified and found functionally enriched in several pathways related to regulation of viral defenses and T cell functions. [Disease Markers] |
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| Investigators explored the efficacy and safety of dendritic cell-cytokine-induced killer cell immunotherapy combined with chemotherapy in the treatment of locally advanced gastric cancer. [Journal of Oncology] |
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| Scientists focus on the detrimental and sometimes beneficial roles of Tregs cells in tumors, our current understanding of recruitment and stabilization of Tregs within the tumor microenvironment, and current Treg-targeted therapeutics. [Trends in Cancer] |
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| Enterome announced that it has signed a strategic R&D collaboration and license agreement with Nestlé Health Science targeting food allergies and inflammatory bowel disease. [Enyrtomr] |
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| IN8bio, Inc. announced the issuance of an additional European patent covering the composition of matter for IN8bio’s Drug Resistant Immunotherapy platform. [IN8bio, Inc.] |
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| August 28 – September 2, 2022 Asheville, North Carolina, United States |
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| University Hospital of North Norway – Tromsø, Norway |
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| Weill Cornell Medical College – New York, New York, United States |
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| Boehringer Ingelheim – Vienna, Austria |
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| LMU Klinikum – München, Germany |
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| The Chinese University of Hong Kong – Hong Kong, China |
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