Immune Regulation News Volume 14.26 | Jul 22 2022

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    2022-07-22 | IRN 14.26


    Immune Regulation News by STEMCELL Technologies
    Vol. 14.26 – 22 July, 2022
    TOP STORY

    Single Cell Sequencing Reveals Trajectory of Tumor-Infiltrating Lymphocyte States in Pancreatic Cancer

    The authors profiled 80,000 T cells from 57 pancreatic ductal adenocarcinoma, 22 uninvolved/normal samples, and cultured tumor-infiltrating lymphocyte using single-cell transcriptomic and T cell receptor analysis.
    [Cancer Discovery]

    Abstract
    ON1099-728 x 90
    PUBLICATIONSRanked by the impact factor of the journal

    Geospatial Immune Heterogeneity Reflects the Diverse Tumor-Immune Interactions in Intrahepatic Cholangiocarcinoma

    Over half of intrahepatic cholangiocarcinoma (iCCA) displayed intratumoral heterogeneity of immune infiltration, and iCCA were classified into sparsely, heterogeneously, and highly infiltrated subgroups with distinct immunogenomic characteristics.
    [Cancer Discovery]

    Abstract

    Integrating Multiplex Immunofluorescent and Mass Spectrometry Imaging to Map Myeloid Heterogeneity in Its Metabolic and Cellular Context

    Investigators present a novel, integrative approach in which 15-color multispectral imaging allows comprehensive cell classification based on multi-marker expression patterns.
    [Cell Metabolism]

    Full ArticleGraphical Abstract

    Targeting Glutamine Metabolism to Enhance Immunoprevention of EGFR-Driven Lung Cancer

    Flow cytometry and single-cell RNA sequencing of the lung tumors reveal that JHU083 increased CD8+ T cell and CD4+ Th1 cell infiltration, while EVax elicits robust Th1 cell-mediated immune responses and protects mice against EGFRL858R mutation-driven lung tumorigenesis.
    [Advanced Science]

    Full Article

    hUC-EVs-ATO Reduce the Severity of Acute GVHD by Resetting Inflammatory Macrophages toward the M2 Phenotype

    An acute graft-versus-host disease model (AGVHD) was established to observe the therapeutic effects of extracellular vesicles from mesenchymal stromal cell-derived human umbilical cords-arsenic trioxides on aGVHD.
    [Journal of Hematology & Oncology]

    Full Article

    Dual Inhibition of CDK12/CDK13 Targets Both Tumor and Immune Cells in Ovarian Cancer

    The dual CDK12/CDK13 inhibitor ZSQ836 exerted potent anticancer activity in cell culture and mouse models and induced transcriptional reprogramming, including downregulation of DNA damage response genes.
    [Cancer Research]

    Abstract

    The N6-Methyladenosine Writer WTAP Contributes to the Induction of Immune Tolerance Post Kidney Transplantation by Targeting Regulatory T Cells

    Wilms tumor 1-associating protein (WTAP) was upregulated in CD4+ T cells of tolerant kidney transplant recipients and positively correlated with Treg cell proportion.
    [Laboratory Investigation]

    Full Article

    Predicted Immune-Related Genes and Subtypes in Systemic Lupus Erythematosus Based on Immune Infiltration Analysis

    309 SLE-related genes were identified and found functionally enriched in several pathways related to regulation of viral defenses and T cell functions.
    [Disease Markers]

    Full Article

    Efficacy of DC-CIK Immunotherapy Combined with Chemotherapy on Locally Advanced Gastric Cancer

    Investigators explored the efficacy and safety of dendritic cell-cytokine-induced killer cell immunotherapy combined with chemotherapy in the treatment of locally advanced gastric cancer.
    [Journal of Oncology]

    Abstract

    Learn about immunological considerations for hPSC banking by watching Dr. David Turner's webinar from the Nature Research Round Table on hPSC Quality
    REVIEWS

    Therapeutic Targeting of Regulatory T Cells in Cancer

    Scientists focus on the detrimental and sometimes beneficial roles of Tregs cells in tumors, our current understanding of recruitment and stabilization of Tregs within the tumor microenvironment, and current Treg-targeted therapeutics.
    [Trends in Cancer]

    Abstract
    INDUSTRY AND POLICY NEWS

    Enterome Signs Major Strategic R&D Collaboration with Nestlé Health Science to Develop and Commercialize New AllerMimics™ and EndoMimics™ Immunotherapies for Food Allergies and Inflammatory Bowel Disease

    Enterome announced that it has signed a strategic R&D collaboration and license agreement with Nestlé Health Science targeting food allergies and inflammatory bowel disease.
    [Enyrtomr]

    Press Release

    Newly Issued European Patent Broadens IN8bio’s Drug Resistant Immunotherapy (DRI) Platform

    IN8bio, Inc. announced the issuance of an additional European patent covering the composition of matter for IN8bio’s Drug Resistant Immunotherapy platform.
    [IN8bio, Inc.]

    Press Release
    FEATURED EVENT

    The Translational Neuroimmunology Conference: From Bench to Bedside and Back

    August 28 – September 2, 2022
    Asheville, North Carolina, United States

    > See All Events

    JOB OPPORTUNITIES

    Scientist – PET Imaging

    University Hospital of North Norway – Tromsø, Norway

    Postdoctoral Scientists – Pluripotent Stem Cells and Developmental Biology

    Weill Cornell Medical College – New York, New York, United States

    Principal Scientist – Cancer Immunology Drug Discovery

    Boehringer Ingelheim – Vienna, Austria

    Postdoctoral Position – Vascular Biology

    LMU Klinikum – München, Germany

    Associate Professor – Thematic Research Programs

    The Chinese University of Hong Kong – Hong Kong, China

    > See All Jobs

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