Immune Regulation News Volume 14.28 | Aug 5 2022

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    2022-08-05 | IRN 14.28


    Immune Regulation News by STEMCELL Technologies
    Vol. 14.28 – 5 August, 2022
    TOP STORY

    A Conserved Bacteroidetes Antigen Induces Anti-Inflammatory Intestinal T Lymphocytes

    The authors identified β-hexosaminidase, a conserved enzyme across commensals of the Bacteroidetes phylum, as a driver of CD4IEL differentiation.
    [Science]

    Abstract
    Find out the estimated cell frequencies and percentages of more than 35 cell types in normal human blood-related sources.
    PUBLICATIONSRanked by the impact factor of the journal

    Manipulating Offense and Defense Signaling to Fight Cold Tumors with Carrier-Free Nanoassembly of Fluorinated Prodrug and siRNA

    A new kind of carrier-free nanoparticle was developed to simultaneously deliver chemotherapeutic drug, cytolytic peptide, and anti-TOX small interfering RNA using a fluorinated prodrug strategy.
    [Advanced Materials]

    Abstract

    Combinations of Anti-GITR Antibody and CD28 Superagonist Induce Permanent Allograft Acceptance by Generating Type 1 Regulatory T Cells

    The authors reported the combined use of a CD28 superagonist and anti–glucocorticoid-induced tumor necrosis factor receptor–related protein monoclonal antibody (G3c) to induce Tr1 cells in vivo.
    [Science Advances]

    Full Article

    Modulation of Pre-mRNA Structure by hnRNP Proteins Regulates Alternative Splicing of MALT1

    Investigators demonstrated that MALT1 splicing depended on RNA structural elements that sequestered the splice sites of the alternatively spliced exon7.
    [Science Advances]

    Full Article

    In Mouse Chronic Pancreatitis CD25+FOXP3+ Regulatory T Cells Control Pancreatic Fibrosis by Suppression of the Type 2 Immune Response

    The authors identified regulatory T cells as central regulators of the fibroinflammatory reaction by a selective depletion of FOXP3-positive cells in a transgenic mouse model of experimental chronic pancreatitis.
    [Nature Communications]

    Full Article

    Elp3-Mediated Codon-Dependent Translation Promotes mTORC2 Activation and Regulates Macrophage Polarization

    The metabolic reprogramming linked to M2 macrophage polarization relied on Elp3 and the translation of multiple candidates, including the mitochondrial ribosome large subunit proteins Mrpl3, Mrpl13, and Mrpl47.
    [EMBO Journal]

    Full ArticleGraphical Abstract

    Store-Operated Calcium Entry Controls Innate and Adaptive Immune Cell Function in Inflammatory Bowel Disease

    T cell-specific deletion of CRAC channel genes in mice showed that Orai1, Stim1, and Stim2-deficient T cells had quantitatively distinct defects in store-operated Ca2+ entry , which correlated with gradually more pronounced impairment of cytokine production by Th1 and Th17 cells and the severity of inflammatory bowel disease.
    [EMBO Molecular Medicine]

    Full ArticleGraphical Abstract

    Tyrosine Kinase Inhibition Alters Intratumoral CD8+ T Cell Subtype Composition and Activity

    To identify limitations imposed by imatinib on the antitumor immune response, investigators performed bulk RNA sequencing, single-cell RNAseq, and flow cytometry to phenotype CD8+ T cell subsets in a genetically engineered mouse model of gastrointestinal stromal tumor.
    [Cancer Immunology Research]

    Abstract

    A Novel EGFRvIII-T Cell Bispecific Antibody for the Treatment of Glioblastoma

    Researchers designed and developed a novel 2+1 epidermal growth factor receptor variant III (EGFRvIII)-T cell bispecific antibodies with optimal pharmacological characteristics and potent anti-tumor activity.
    [Molecular Cancer Therapeutics]

    Abstract

    Human Umbilical Cord Mesenchymal Stem Cells Derived Extracellular Vesicles Regulate Acquired Immune Response of Lupus Mouse In Vitro

    Scientists investigated whether human umbilical cord mesenchymal stem cells derived extracellular vesicles could regulate abnormal immune responses of T cells or B cells in systemic lupus erythematosus.
    [Scientific Reports]

    Full Article

    Explore this validated protocol for high-efficiency CRISPR-Cas9 gene editing of Human Primary T Cells.
    REVIEWS

    Neuroinflammation: Extinguishing a Blaze of T Cells

    Investigators focus on the control of the immune response by regulatory T cells and describe the counteracting processes that preserve their identity under inflammatory challenges.
    [Immunological Reviews]

    Abstract

    Regulatory T Cells in Skeletal Muscle Repair and Regeneration: Recent Insights

    Tregs regulate homeostasis within the immune system and self-immune tolerance, and play a crucial role in skeletal muscle repair and regeneration.
    [Cell Death & Disease]

    Abstract

    Regulatory T Cells (Tregs) in Lymphoid Malignancies and the Impact of Novel Therapies

    The authors discuss studies investigating Treg immunobiology in B cell lymphoid malignancies, focusing on clinical correlations, mechanisms of accumulation, phenotype, and function.
    [Frontiers in Immunology]

    Full Articl
    INDUSTRY AND POLICY NEWS

    Gilead Sciences to Acquire MiroBio

    Gilead Sciences, Inc. and MiroBio, abiotechnology company focused on restoring immune balance with agonists targeting immune inhibitory receptors, announced that the companies have entered into a definitive agreement pursuant to which Gilead will acquire MiroBio for approximately $405 million in cash.
    [Gilead Sciences, Inc.]

    Press Release

    Sanofi and Innovent Biologics Enter Strategic Collaboration to Accelerate Development of Oncology Medicines and Expand Presence in China

    Sanofi and Innovent Biologics announced a collaboration to bring innovative medicines to patients in China with difficult-to-treat cancers. This strategic partnership demonstrates Sanofi and Innovent’s commitment to bringing high quality oncology medicines to patients in China.
    [Sanofi]

    Press Release
    FEATURED EVENT

    Neuroimmunometabolism – Obesity at the Crossroads between Neuroimmunity and Immunometabolism

    October 7 – 10, 2022
    Beaver Run Resort, Colorado, United States

    > See All Events

    JOB OPPORTUNITIES

    Staff Associate – Dependencies in Esophageal and Gastric Cancer.

    Columbia University – New York, New York, United States

    Postdoctoral Researcher – Immuno-Oncology

    Essen University Hospital – Essen, Germany

    Lecturer/Senior Lecturer – Immunomodulation

    King’s College London – London, United Kingdom

    Research Associate – Pluripotent Stem Cells

    The University of British Columbia – Vancouver, British Columbia, Canada

    Research Scientist – Inflammation

    Gilead Sciences, Inc. – Foster City, California, United States

    > See All Jobs

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