Immune Regulation News Volume 2.02 | Jan 22 2010

    0
    90

    Immune Regulation News 2.02, January 22, 2010.
    In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  Events Subscribe  |  Unsubscribe

    TOP STORY

    Cancer Stem Cells Suppress Immune Response Against Brain Tumor
    Cancer-initiating cells that launch glioblastoma multiforme, the most lethal type of brain tumor, also suppress an immune system attack on the disease. [M. D. Anderson Cancer Center, Houston]

    Request A Poster 
    Isolate Untouched Cells for
    Antigen Processing and Presentation
    with EasySep®
     
     
    REQUEST A POSTERSTEMCELL Technologies Inc
     

    SPECIAL FEATURE

    Video – RoboSep® – Product Tour


    SCIENCE NEWS

    How Anticancer Immune Responses Are Suppressed
    Scientists have identified a molecular pathway that enhances the immunosuppressive functions of tumor-associated mouse and human myeloid-derived suppressor cells. [Science Daily]

    Identified: Switch that Turns On Allergic Disease in People
    A new study in human cells has singled out a molecule that specifically directs immune cells to develop the capability to produce an allergic response. The signaling molecule, called thymic stromal lymphopoietin, is key to the development of allergic diseases such as asthma, atopic dermatitis (eczema) and food allergy. [M. D. Anderson Cancer Center, Houston]

    Babraham Discovery May Aid Transplantation and Regenerative Medicine
    Research provides new insights into how our immune system produces T cells, a type of white blood cell that is an essential part of the body’s immune surveillance system for fighting infection. [Babraham Institute, Cambridge]

    EasySep_645x110_v01


    CURRENT PUBLICATIONS

    Effectors and Memories: Bcl-6 and Blimp-1 in T and B Lymphocyte Differentiation
    The new findings unexpectedly point to the Bcl-6 and Blimp-1 regulatory axis as a ubiquitous mechanism for controlling effector and memory lymphocyte differentiation and function. [Nat Immunol]

    Membrane-Associated Hsp72 from Tumor-Derived Exosomes Mediates STAT3-Dependent Immunosuppressive Function of Mouse and Human Myeloid-Derived Suppressor Cells
    Here, researchers have isolated tumor-derived exosomes (TDEs) from mouse cell lines and shown that an interaction between TDE-associated Hsp72 and myeloid-derived suppressor cells (MDSCs) determines the suppressive activity of the MDSCs via activation of Stat3. [J Clin Invest]

    The Architectural Pattern of FOXP3-Positive T Cells in Follicular Lymphoma is an Independent Predictor of Survival and Histologic Transformation
    Researchers conclude that FOXP3+ cell distribution significantly predicts survival and risk of transformation in follicular lymphoma. [Blood]

    Tolerogenic Dendritic Cells Generated with Different Immunosuppressive Cytokines Induce Antigen-Specific Anergy and Regulatory Properties in Memory CD4+ T Cells
    In this study, researchers generated human monocyte-derived dendritic cells (DCs) by culture with GM-CSF and IL-4 (control DCs), as well as tolerogenic DCs (tDCs) by adding IL-10, IL-10/TGF-(beta)1, or IL-10/IL-6. [J Immunol]

    Myelin Basic Protein Priming Reduces the Expression of FOXP3 in T Cells Via Nitric Oxide
    The present study was undertaken to investigate the crosstalk between nitric oxide and regulatory T cells. [J Immunol]

    Dendritic Cells Support Homeostatic Expansion of FOXP3+ Regulatory T Cells in Foxp3.LuciDTR Mice
    For the investigation of regulatory T cell (Treg) homeostatic expansion, researchers introduced in this study novel BAC transgenic mice, designated Foxp3.LuciDTR, coexpressing enhanced GFP, luciferase for bioluminescence imaging of Tregs, and the diphtheria toxin receptor for specific ablation of Tregs. [J Immunol]

    Ex Vivo Monitoring of Human Cytomegalovirus-Specific CD8+ T Cell Responses Using the QuantiFERON(R)-CMV Assay in Allogeneic Hematopoietic Stem Cell Transplant Recipients Attending an Irish Hospital
    The QuantiFERON®-CMV assay for cellular human cytomegalovirus-specific immunity was evaluated in allogeneic hematopoietic stem cell transplant recipients recipients (n = 43) and patients with hematological malignancies (n = 29) attending a tertiary-care Irish hospital.  [J Med Virol]

    Book A Demo 
    Isolate Cells Directly from
    Leukapheresis Products
    with the "Easy 50" EasySep® Magnet
     
     
    BOOK A DEMOSTEMCELL Technologies Inc
     

    INDUSTRY NEWS

    Novartis Edges Ahead of Merck KGaA in Multiple Sclerosis Race
    Swiss drugmaker Novartis has edged ahead of German rival Merck KGaA in the race to get the first oral multiple sclerosis treatment to market, having now filed for approval in the United States and Europe. [Reuters Press Release]

    Fast Forward, Juvenile Diabetes Research Foundation And Axxam SpA Join Forces To Develop Treatments For Multiple Sclerosis And Type 1 Diabetes
    Fast Forward, LLC, and the Juvenile Diabetes Research Foundation announced a collaborative partnership with Axxam SpA to develop new treatments for two autoimmune diseases, multiple sclerosis and type 1 diabetes. [Axxam SpA Press Release]


    POLICY NEWS

    Advisory Committees; Tentative Schedule of Meetings for 2010 [Food and Drug Administration, United States]

    Proposed FDA Rulemaking on Informed Consent Requirements (NOT-OD-10-046) [National Institutes of Health, United States]

    PHS 2010-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (PA-10-051) [National Institutes of Health, United States]

    IACUC 101 and 201 PLUS Workshops: February 24-25, 2010 in Lafayette, LA (NOT-OD-10-044) [National Institutes of Health, United States]


    EVENTS

    9th International Conference on New Trends in Immunosuppression and Immunotherapy
    February 4-6, 2010
    Geneva, Switzerland

    13th International Conference on Lymphocyte Activation and Immune Regulation: Inflammasome and Inflammation
    February 5-7, 2010
    Newport Beach, United States

    Keystone Symposia: Tolerance and Autoimmunity
    February 21-26, 2010
    Taos, United States

    World Immune Regulation Meeting – IV
    March 29-April 1, 2010
    Davos, Switzerland

    IMMUNOLOGY 2010
    May 7-11, 2010
    Baltimore, United States

    14th International Congress of Immunology
    August 22-27, 2010
    Kobe, Japan

    Visit our events page  to stay up to date with the latest events in the cell, gene and immunotherapy community.



    JOB OPPORTUNITIES

    Business Development Europe – Cell Therapy Products (PALL Corporation)

    Scientific Communications & Publishing Coordinator (STEMCELL Technologies)

    Information Systems Manager (STEMCELL Technologies)

    Human Resources Generalist (STEMCELL Technologies)

    Manufacturing & Repair Manager, Automation Instruments (STEMCELL Technologies)

    Research & Development Scientist – Pancreatic Cell Biology (STEMCELL Technologies)

    Research & Development Scientist – Endothelial Cell Biology (STEMCELL Technologies)

    Research & Development Scientist – Epithelial Cell Biology (STEMCELL Technologies)

    Customer Service Representative (STEMCELL Technologies)

    Data Entry Assistant – Marketing (STEMCELL Technologies)

    Recruit Top Talent

    Reach more than 11,000 potential candidates by posting your organization’s career opportunities with Cell Therapy News.

    Visit here to post your career opportunities.



    Have we missed an important article or publication in Immune Regulation News? Click here to submit!

     

    Learn more about Immune Regulation News: Archives  |  Events  |  Subscribe  |  Contact Us