Immune Regulation News Volume 2.12 | Apr 9 2010

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    Immune Regulation News 2.12, April 9, 2010.
    In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  EventsSubscribe  |  Unsubscribe


    TOP STORY

    Immune System Key: New Study Questions Earlier Conclusions about the Kinetics of T Cell Receptors
    Based on two techniques that mechanically study receptors as they operate on T cell membranes, the findings could lead to a reevaluation of prior conclusions. [Press release from Georgia Institute of Technology discussing online prepublication in Nature]

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    SCIENCE NEWS

    Researchers Use Nanoparticle “Vaccine” to Cure Type 1 Diabetes in Mice
    Using an innovative nanotechnology-based “vaccine,” researchers were able to successfully restore normal blood sugar in mice with type 1 diabetes, and also slow the onset of diabetes in mice at risk for the disease. [Press release from Juvenile Diabetes Research Foundation discussing online prepublication in Immunity]

    University of Central Florida Professor Harnesses Plant ‘Power’ to Fight Hemophilia
    Treating hemophilia can sometimes be deadly because many patients suffer fatal allergic reactions to the expensive protein that doctors use to make their blood clot. Now researchers have devised a way that could help patients develop a tolerance to the therapeutic protein before they seek treatment to prevent the potentially deadly reactions. [Press release from University of Central Florida discussing online prepublication in Proceedings of the National Academy of Sciences U S A]

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    CURRENT PUBLICATIONS

    Conversion of Adult Pancreatic Alpha-Cells to Beta-Cells After Extreme Beta-Cell Loss
    Researchers show beta-cell regeneration in a transgenic model of diphtheria-toxin-induced acute selective near-total beta-cell ablation. [Nature]

    The Kinetics of Two-Dimensional TCR and pMHC Interactions Determine T Cell Responsiveness
    2D data suggest rapid antigen sampling by T cells and serial engagement of a few agonist peptide-major histocompatibility complexes (pMHCs) by T cell receptor (TCR)s in a large self pMHC background. Thus, the cellular environment amplifies the intrinsic TCR-pMHC binding to generate broad affinities and rapid kinetics that determine T cell responsiveness. [Nature]

    Protein Kinase C-Theta Mediates Negative Feedback on Regulatory T Cell Function
    Inhibition of PKC-theta protected regulatory T cell (Treg) from inactivation by TNF-alpha, restored activity of defective Treg from rheumatoid arthritis patients, and enhanced protection of mice from inflammatory colitis. [Science]

    Induction of Lymphoidlike Stroma and Immune Escape by Tumors That Express the Chemokine CCL21
    Researchers suggest that by altering the tumor microenvironment, CCL21-secreting tumors shift the host immune response from immunogenic to tolerogenic, thereby facilitating tumor progression. [Science]

    T Helper Type 1 and 17 Cells Determine Efficacy of Interferon-Beta in Multiple Sclerosis and Experimental Encephalomyelitis
    Investigators have found congruence in outcome between responses to interferon-beta in experimental autoimmune encephalomyelitis and relapsing-remitting multiple sclerosis. [Nat Med]

    Reversal of Autoimmunity by Boosting Memory-like Autoregulatory T Cells
    Researchers show that progression to autoimmune diabetes results in the conversion of naive low-avidity autoreactive CD8+ T cells into memory-like autoregulatory cells that can be expanded in vivo with nanoparticles coated with disease-relevant peptide-major histocompatibility complexes. [Immunity]

    TRAF6 Inhibits Th17 Differentiation and TGF-Beta-Mediated Suppression of IL-2
    Here researchers report that CD4+ T cells lacking the molecular adaptor TNF receptor-associated factor 6 (TRAF6) exhibit a specific increase in Th17 differentiation in vivo and in vitro. [Blood]

    Toll-Like Receptor Induced Changes in Glycolytic Metabolism Regulate Dendritic Cell Activation
    These data pinpoint toll-like receptor-mediated metabolic conversion as essential for dendritic cell maturation and function, and reveal it as a potential target for intervention in the control of excessive inflammation and inappropriately regulated immune responses. [Blood]

    Plasmacytoid Dendritic Cells Resident in Human Thymus Drive Natural Regulatory T Cell Development
    Here researchers report that plasmacytoid dendritic cells (pDCs) resident in the human thymus, when activated with CD40L plus IL-3, efficiently promoted the generation of CD4+CD25+Foxp3+ natural regulatory T cells from autologous thymocytes. [Blood]

    Lentiviral-Mediated Foxp3 RNAi Suppresses Tumor Growth of Regulatory T Cell-Like Leukemia in a Murine Tumor Model
    Inhibiting Foxp3 gene expression by shRNAs effectively decreases tumor growth of regulatory T cell-like leukemia. [Gene Ther]

    INDUSTRY NEWS

    US Seeks to Make Science Free For All
    Moves to make research funded by the US government available to everyone could mark a turning point in a publishing revolution. [Nature News]

    CureDM Partners Novel Diabetes Treatment With Sanofi-Aventis
    CureDM, LLC announced that an agreement has been signed with Sanofi-Aventis for the exclusive worldwide license of Pancreate™, a novel islet neogenesis agent for the treatment of type 1 and type 2 diabetes. [CureDM, LLC. Press Release]

    Portola Pharmaceuticals Announces Initiation of Phase I Clinical Trial of PRT062607, an Oral, Syk-Specific Inhibitor for Chronic Inflammatory Disease Indications
    Portola Pharmaceuticals, Inc. announced that it has initiated its first in human Phase I trial in healthy volunteers of PRT062607, a novel, oral Syk-specific kinase inhibitor in development to treat chronic inflammatory diseases, including rheumatoid arthritis, and certain cancers, including non-Hodgkin’s lymphoma and chronic lymphocytic leukemia. [Portola Pharmaceuticals, Inc. Press Release]

    POLICY NEWS

    Enhancing Peer Review: Updated Processes for the Review of All Ruth L. Kirschstein National Research Service Award Fellowship Applications (NOT-OD-10-071) [National Institutes of Health, United States]

    NIH Will Require the Electronic Submission of Appointment Forms and Termination Notices via xTrain for Research Training, Fellowship, Education, and Career Awards Beginning January 2011 (NOT-OD-10-072) [National Institutes of Health, United States]

    Small Business Innovation Research Award Levels Adjusted to $150,000 (Phase I) and $1,000,000 (Phase II) (NOT-OD-10-079) [National Institutes of Health, United States]

    Notice of Change in Expiration Date for Program Announcement on Bioengineering Research Partnerships (PAR-07-352) (NOT-EB-10-001) [National Institutes of Health, United States]

    Revision of the Requirements for Constituent Materials (Docket No. FDA-2010-N-0099) [Food and Drug Administration, United States]

    Voting and Nonvoting Consumer Representative Members on Public Advisory Committees and Panels; Notice of Public Meeting (Docket No. FDA-2010-N-0001) [Food and Drug Administration, United States]

    Determination of Regulatory Review Period for Purposes of Patent Extension; LUSEDRA (Docket Nos. FDA-2009-E-0202 and FDA-2009-E-0204) [Food and Drug Administration, United States]

    Revision of Organization and Conforming Changes to Regulations (Docket No. FDA-2010-N-0148) [Food and Drug Administration, United States]

    Administrative Practices and Procedures; Good Guidance Practices; Technical Amendment (Docket No. FDA-1999-N-3539) [Food and Drug Administration, United States]

    2010 Biological License Application Supplement Noteworthy Approvals [Food and Drug Administration, United States]

    EVENTS

    American Association for Cancer Research (AACR) 101st Annual Meeting 2010
    April 17-21, 2010
    Washington, DC, United States

    23rd Annual Canadian Society for Immunology (CSI) Conference
    April 23-26, 2010
    Niagara Falls, Canada

    97th Annual Meeting of the American Association of Immunologists (AAI)
    May 7-11, 2010
    Baltimore, United States

    29th Congress of the European Academy of Allergy and Clinical Immunology (EAACI)
    June 5-9, 2010
    London, United Kingdom

    Keystone Symposia: Innate Immunity – Mechanisms Linking with Adaptive Immunity (D3)
    June 7-12, 2010
    Dublin, Ireland

    Federation of Clinical Immunology Societies (FOCIS) 2010
    June 24-27, 2010
    Boston, United States

    Frontiers in Immunology Research (FIRN) 2010 International Conference
    July 22-26, 2010
    Athens, Greece

    14th International Congress of Immunology
    August 22-27, 2010
    Kobe, Japan

    7th Annual RNAi & miRNA Europe Select BioSciences
    September 14-15, 2010
    Dublin, Ireland

    5th International Conference on Gene Regulation in Lymphocyte Development
    October 9-14, 2010
    Chania, Greece

    Autumn Immunology Conference 2010
    November 19-22, 2010
    Chicago, United States

    Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

     

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