SCIENCE NEWS Important Control Mechanism Behind Autoimmune Diseases Discovered Researchers have discovered a new control mechanism in our immune system. The discovery is of potential significance to the treatment of serious diseases such as multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus. [Press release from Karolinska Institutet discussing online prepublication in The Journal of Experimental Medicine] Self-Help, Tumors Promote Their Own Metastasis Current research suggests that tumor-secreted exosomes inhibit the immune response, enhancing tumor metastasis. [Press release from Biocompare discussing online prepublication in The American Journal of Pathology] FDA Approval of New Prostate Treatment Shows Promise of Cancer Immunotherapy The U.S. Food and Drug Administration approval of Dendreon’s Provenge® (sipuleucel-T) to treat certain men with advanced prostate cancer marks a significant advance in the development of biological therapy for cancer treatment. [International Society for Biological Therapy of Cancer Press Release]
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CURRENT PUBLICATIONS NLRC5 Negatively Regulates the NF-KappaB and Type I Interferon Signaling Pathways Here, researchers show that NLRC5, a member of the highly conserved NOD-like protein family, can inhibit the IKK complex and RIG-I/MDA5 function. [Cell] The Transcription Factor PU.1 is Required for the Development of IL-9-Producing T Cells and Allergic Inflammation Researchers show that the ETS-family transcription factor PU.1 was required for the development of an interleukin 9-secreting subset of helper T cells. [Nat Immunol] Autonomous Role of Medullary Thymic Epithelial Cells in Central CD4+ T Cell Tolerance Their data document an autonomous contribution of medullary thymic epithelial cells to both dominant and recessive mechanisms of CD4+ T cell tolerance and support an avidity model of regulatory T cell development versus deletion. [Nat Immunol] Early B Cell Factor 1 Regulates B Cell Gene Networks by Activation, Repression, and Transcription- Independent Poising of Chromatin To gain insight into the molecular basis of Ebf1 function in early-stage B cells, researchers combined a genome-wide ChIP sequencing analysis with gain- and loss-of-function transcriptome analyses. [Immunity] Transcription Factors Foxo3a and Foxo1 Couple the E3 Ligase Cbl-B to the Induction of Foxp3 Expression in Induced Regulatory T Cells This study reveals that Foxo factors promote transcription of the Foxp3 gene in induced regulatory T cells, and thus provides new mechanistic insight into Foxo-mediated T cell regulation. [J Cell Biol] Invariant NKT Cells Limit Activation of Autoreactive CD1d-Positive B Cells Here, researchers identify a suppressive role for invariant natural killer T cells in a model where autoantibody production is triggered by an increased load of circulating apoptotic cells, resembling the situation in systemic lupus erythematosus patients. [J Cell Biol] Treatment of Autoimmune Arthritis Using RNA Interference-Modulated Dendritic Cells Here, researchers describe the induction of RNA interference through administering short interfering RNA as a means of specifically generating tolerogenic dendritic cells. [J Immunol] Identification and Characterization of a Lupus Suppressor 129 Locus on Chromosome 3 In this study, researchers have generated a B6 congenic strain harboring the 129 allele of Sle18 and intercrossed this line with the lupus-prone B6.129-Sle16 strain. [J Immunol] Contribution of MyD88 to the Tumor Exosome-Mediated Induction of Myeloid Derived Suppressor Cells In this study, researchers observed that mice pretreated with tumor exosomes had a significant acceleration of tumor metastasis in the lung. Tumor metastasis correlated significantly with an increase in recruitment of more myeloid-derived suppressor cells in the lung of C57BL/6j (B6) mice pretreated with tumor exosomes. [Am J Pathol]
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POLICY NEWS Details of New Wellcome Trust Investigator Awards Announced The Wellcome Trust announces further details of its Investigator Awards, a major new scheme to support world-class researchers to tackle ambitious research questions about health and disease. [Wellcome Trust Press Release] Science Panel Cuts Authorization Levels for Three COMPETES Agencies The House of Representatives Science and Technology Committee scaled back proposed funding levels for three key science agencies as part of its reauthorization of the America COMPETES Act. [The House of Representatives Science and Technology Committee, United States] Commission to Boost Research and Innovation by Making it Easier to Apply for and Manage European Union Grants The European Commission has unveiled a plan to simplify the procedures for taking part in European Union-funded research projects. [European Research, Innovation and Science Commissioner, European Union] Final Opportunity to Attend a 2010 NIH Regional Seminar on Program Funding & Grants Administration: Register Now for Portland, OR (June 24-25, 2010) (NOT-OD-10-092) [National Institutes of Health, United States] Frequently Asked Questions (FAQ) for: Centers of Research Translation (CORT) (P50) RFA-AR-11-002 (NOT-AR-10-035) [National Institutes of Health, United States] Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Predoctoral Fellows in PharmD/PhD Programs (F31) (PA-10-178) [National Institutes of Health, United States] Extension of Expiration Date for PA-07-277, PA-06-367, and PA-06-368: Research on Ethical Issues in Human Subjects Research (NOT-OD-10-086) [National Institutes of Health, United States] Guidance for Industry: Requalification Method for Reentry of Blood Donors Deferred Because of Reactive Test Results for Antibody to Hepatitis B Core Antigen (Anti-HBc); Availability (Docket No. FDA-2008-D-0263) [Food and Drug Administration, United States] Emerging Infectious Diseases: Evaluation to Implementation for Transfusion and Transplantation Safety and Quantitative Risk Assessment: Blood Safety and Availability; Public Workshops (Docket No. FDA-2010-N-0001) [Food and Drug Administration, United States]
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EVENTS 29th Congress of the European Academy of Allergy and Clinical Immunology (EAACI) June 5-9, 2010 London, United Kingdom Keystone Symposia: Innate Immunity – Mechanisms Linking with Adaptive Immunity (D3) June 7-12, 2010 Dublin, Ireland Federation of Clinical Immunology Societies (FOCIS) 2010 June 24-27, 2010 Boston, United States The 2nd International Conference on Regulatory T Cells and TH17 Cells and Clinical Application in Human Diseases July 17-20, 2010 Shanghai, China Frontiers in Immunology Research (FIRN) 2010 International Conference July 22-26, 2010 Athens, Greece 14th International Congress of Immunology August 22-27, 2010 Kobe, Japan Select BioSciences 7th Annual RNAi & miRNA Europe September 14-15, 2010 Dublin, Ireland 5th International Conference on Gene Regulation in Lymphocyte Development October 9-14, 2010 Chania, Greece Autumn Immunology Conference 2010 November 19-22, 2010 Chicago, United States Cell Symposia: Influenza – Translating Basic Insights December 2-4, 2010 Washington, D.C., United States Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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