CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)
Quiescent Hematopoietic Stem Cells are Activated by IFN-Gamma in Response to Chronic Infection
Here researchers show, using an in vivo mouse model of Mycobacterium avium infection, that an increased proportion of long-term repopulating hematopoietic stem cells proliferate during M. avium infection, and that this response requires interferon-gamma but not interferon-alpha signalling. [Nature]
Tumor-Induced Tolerance and Immune Suppression Depend on the C/EBP(Beta) Transcription Factor
Researchers showed that among factors produced by various experimental tumors, the cytokines GM-CSF, G-CSF, and IL-6 allowed a rapid generation of myeloid-derived suppressor cells from precursors present in mouse and human bone marrow. [Immunity]
Inhibition of Lipid Antigen Presentation in Dendritic Cells by HIV-1 Vpu Interference with CD1d Recycling from Endosomal Compartments
Given that the interaction with CD1d-expressing Dendritic cells is central to the ability of natural killer T (NKT) cells to regulate immunity, these data suggest that interference with the CD1d antigen presentation pathway represents an HIV-1 strategy to evade innate cellular immune responses, and imply a role for the innate-like CD1d-restricted NKT cells in the host defense against HIV-1. [Blood]
Allosteric Inhibition of Macrophage Migration Inhibitory Factor Revealed by Ibudilast
As described herein, the phosphodiesterase (PDE) inhibitor AV411 (ibudilast; 3-isobutyryl-2-isopropylpyrazolo-[1,5-a]pyridine) and its PDE-inhibition-compromised analog AV1013 inhibit the catalytic and chemotactic functions of the proinflammatory protein, macrophage migration inhibitory factor. [Proc Natl Acad Sci U S A]
Systemically Dispersed Innate IL-13-Expressing Cells in Type 2 Immunity
Here, researchers use IL-4 and IL-13 reporter mice to track lineage-negative innate cells that arise during type 2 immunity or in response to IL-25 and IL-33 in vivo. [Proc Natl Acad Sci U S A]
Identification of an IL-27/Osteopontin Axis in Dendritic Cells and its Modulation by IFN-Gamma Limits IL-17-Mediated Autoimmune Inflammation
The results identify a previously unknown pathway by which IFN-gamma limits IL-17-mediated autoimmune inflammation through differential regulation of osteopontin and IL-27 expression in dendritic cells. [Proc Natl Acad Sci U S A]
Enzymatically Active Single Chain Caspase-8 Maintains T Cell Survival During Clonal Expansion
Here, researchers show that caspase-8-deficient T cell survival was rescued by enzymatically active, but not inactive, casp8-expressing retroviruses. [Cell Death Differ]
TLR4-Mediated Skin Carcinogenesis is Dependent on Immune and Radioresistant Cells
The results suggest that the initial release of high mobility group box-1 protein triggers a TLR4-dependent inflammatory response that leads to tumour development. [EMBO J]
Control of T Cell Reactivation by Regulatory Qa-1-Restricted CD8+ T Cells
These experiments provide new insight into a CD8+ T cell compartment that regulates the immediate reactivation of conventional T cells and natural killer T cells. [J Immunol]
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INDUSTRY NEWS
Idera Pharmaceuticals Announces Preliminary Data from Phase I Clinical Trial of IMO-3100, a Toll-like Receptor Antagonist Drug Candidate for Autoimmune and Inflammatory Diseases
Idera Pharmaceuticals, Inc. announced preliminary results from a Phase I clinical trial of IMO-3100, its lead Toll-like Receptor (TLR) 7 and TLR9 antagonist drug candidate for potential applications in autoimmune and inflammatory diseases. [Idera Pharmaceuticals, Inc. Press Release]
VBL Therapeutics Present Data on VB-201 for Rheumatoid Arthritis at EULAR Annual Meeting
VBL Therapeutics announced the presentation of preclinical data from the company’s lead program, VB-201, at the European League Against Rheumatism (EULAR) Annual European Congress of Rheumatology. [VBL Therapeutics Press Release]
Cytheris Closes $15 Million Series D Financing
Cytheris SA, a clinical stage biopharmaceutical company focused on research and development of new therapies for immune modulation, announced that it has completed a $15 million Series D financing. [Cytheris SA Press Release]
The Iacocca Family Foundation and Kineta Announce New Partnership on Type I Diabetes Mellitus Drug Development Program
Kineta, Inc. joined with The Iacocca Family Foundation to announce a new investment partnership to speed development of Kineta’s preclinical autoimmune drug candidate, ShK-186, and its multiple applications to treat Type I diabetes mellitus. [Kineta, Inc. Press Release]
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POLICY NEWS
STAR METRICS: New Way to Measure the Impact of Federally Funded Research
A new initiative–Science and Technology for America’s Reinvestment: Measuring the Effect of Research on Innovation, Competitiveness and Science, or STAR METRICS–promises to monitor the impact of federal science investments on employment, knowledge generation, and health outcomes. [National Institutes of Health, United States]
Market Withdrawal of GAMMAGARDLIQUID, Immune Globulin Intravenous (Human)
This voluntary market withdrawal is being conducted as a precautionary measure due to an increased number of adverse event reports of allergic reactions. [Food and Drug Administration, United States]
FDA Announces Collaboration with Drugs.com
The U.S. Food and Drug Administration announced that it will collaborate with the website Drugs.com to expand access to the FDA’s consumer health information. [Food and Drug Administration, United States]
Administrative Supplements to Increase Public Awareness of Pediatric Cancers and Available Treatments and Research (NOT-CA-10-026) [National Institutes of Health, United States]
2010 Biological License Application Approvals [Food and Drug Administration, United States]
2010 Biological Device Application Approvals [Food and Drug Administration, United States]
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EVENTS
Phacilitate Vaccine & Immunotherapy Forum 2010
June 21-23, 2010
Barcelona, Spain
Federation of Clinical Immunology Societies (FOCIS) 2010
June 24-27, 2010
Boston, United States
The Second International Conference on Regulatory T Cells and Th17 Cells and Clinical Application in Human Diseases
July 17-20, 2010
Shanghai, China
Frontiers in Immunology Research (FIRN) 2010 International Conference
July 22-26, 2010
Athens, Greece
14th International Congress of Immunology
August 22-27, 2010
Kobe, Japan
Select Biosciences 7th Annual RNAi & miRNA Europe
September 14-15, 2010
Dublin, Ireland
5th International Conference on Gene Regulation in Lymphocyte Development
October 9-14, 2010
Chania, Greece
Autumn Immunology Conference 2010
November 19-22, 2010
Chicago, United States
Cell Symposia: Influenza – Translating Basic Insights
December 2-4, 2010
Washington, D.C., United States
Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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