SCIENCE NEWS Why Do Certain Diseases Go Into Remission During Pregnancy? During pregnancy, many women experience remission of autoimmune diseases like multiple sclerosis and uveitis. Now, scientists have described a biological mechanism responsible for changes in the immune system that helps to explain the remission. [Press release from the University of Michigan discussing online prepublication in the American Journal of Reproductive Immunology] Insulin Peptide May Point to Solution for Type 1 Diabetes Researchers have identified the precise protein fragment, or peptide, that can trigger diabetes in mice. [Press release from National Jewish Health discussing online prepublication in Proceedings of the National Academy of Sciences USA] Blood Deficiencies are Strong Predictors of Poor Outcome For healthcare professionals diagnosing primary Sjögren’s Syndrome, the incidence of blood based deficiencies is the strongest predictor of a poor outcome in patients according to the results of a study presented at EULAR 2010, the Annual Congress of the European League Against Rheumatism in Rome, Italy. [Press release from EurekAlert! discussing research presented at the Annual Congress of the European League Against Rheumatism in Rome (EULAR 2010)]
|
|
CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells Researchers report that autoimmune arthritis was strongly attenuated in the K/BxN mouse model under germ-free conditions, accompanied by reductions in serum autoantibody titers, splenic autoantibody-secreting cells, germinal centers, and the splenic T helper 17 cell population. [Immunity] Discrete Roles of STAT4 and STAT6 Transcription Factors in Tuning Epigenetic Modifications and Transcription during T Helper Cell Differentiation Using chromatin immunoprecipitation and massive parallel sequencing, researchers quantitated the full complement of STAT-bound genes, concurrently assessing global STAT-dependent epigenetic modifications and gene transcription by using cells from cognate STAT-deficient mice. [Immunity ] Apoptosis Threshold Set by Noxa and Mcl-1 after T Cell Activation Regulates Competitive Selection of High-Affinity Clones Here researchers showed that upon T cell activation, the proapoptotic molecule Noxa (encoded by Pmaip1) and its antagonist Mcl-1 were induced. [Immunity] Revised Map of the Human Progenitor Hierarchy Shows the Origin of Macrophages and Dendritic Cells in Early Lymphoid Development Here researchers provide a comprehensive analysis of the human hematopoietic hierarchy by clonally mapping the developmental potential of seven progenitor classes from neonatal cord blood and adult bone marrow. [Nat Immunol] Inducible Foxp3+ Regulatory T Cell Development by a Commensal Bacterium of the Intestinal Microbiota Researchers report that a prominent human commensal, Bacteroides fragilis, directs the development of Foxp3+ regulatory T cells with a unique “inducible” genetic signature. [Proc Natl Acad Sci U S A] Exploiting Cross-Priming to Generate Protective CD8 T Cell Immunity Rapidly Here, researchers demonstrate that in vivo cross-priming with cell-associated antigens or antigen-coated, biodegradable microspheres in the absence of adjuvant quickly generates CD8 T cells that display the phenotype and function of long-term memory populations. [Proc Natl Acad Sci U S A] Critical Role for TNF in the Induction of Human Antigen-Specific Regulatory T Cells by Tolerogenic Dendritic Cells Researchers studied the role of TNF in the induction of antigen-specific regulatory T cells by tolerogenic vitamin D3-modulated human dendritic cells, which previously were shown to release high amounts of soluble TNF upon maturation with LPS. [J Immunol] NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses To investigate the role of nucleotide-binding domain, leucine-rich repeat containing protein family, pyrin domain containing 3 (NLRP3) protein in multiple sclerosis (MS), researchers used a mouse model of MS, experimental autoimmune encephalomyelitis. [J Immunol] Altered Effector CD4+ T Cell Function in IL-21R-/- CD4+ T Cell-Mediated Graft-Versus-Host Disease It was previously shown that transplantation with IL-21R gene-deficient splenocytes resulted in less severe graft-versus-host disease than was observed with wild type splenocytes. In this study, researchers sought to find mechanism(s) explaining this observation. [J Immunol] Tumor Cells Engineered to Codisplay on Their Surface 4-1BBL and LIGHT Costimulatory Proteins as a Novel Vaccine Approach for Cancer Immunotherapy Researchers herein demonstrate that TC-1 tumor cells can be rapidly and efficiently engineered to codisplay on their surface two costimulatory proteins, SA-4-1BBL and SA-LIGHT, simultaneously. [Cancer Gene Ther] Leukocyte Pyruvate Kinase Expression is Reduced in Normal Human Pregnancy but not in Pre-Eclampsia To examine the immunoregulatory role of glycolysis in pregnancy, researchers evaluated the properties of pyruvate kinase in leukocytes from non-pregnant women and those with normal pregnancy and pre-eclampsia. [Amer J Reprod Immunol]
|
|
INDUSTRY NEWS CIRM Allocates $25 Million to Overcome Immune Rejection of Stem Cell Transplantation Therapies The Governing Board of the California Institute for Regenerative Medicine, the state stem cell agency created by proposition 71, approved $25 million to fund 19 projects intended to overcome immune rejection of transplanted stem cells. [California Institute for Regenerative Medicine Press Release] Lupus Research Institute Underscores Urgent Need for Research in Pediatric Lupus at International Lupus Congress The Lupus Research Institute National Coalition of state and local lupus groups, alarmed at the crucial need for answers to the devastating effects of lupus when diagnosed in the young, is sponsoring key programming in lupus pediatrics at the International Lupus Congress in Vancouver. [Lupus Research Institute Press Release] Anthera Enrolls First Patients in Pivotal Varespladib Phase III Clinical Study Anthera Pharmaceuticals, Inc. announced patient enrollment has commenced in the Company’s pivotal VISTA-16 (Vascular Inflammation Suppression to Treat Acute Coronary Syndrome for 16 Weeks) Phase III clinical study of varespladib (A-002). [Anthera Pharmaceuticals, Inc. Press Release] Tolera Therapeutics Granted Orphan Drug Designation For Treatment Of Type I Diabetes Mellitus Tolera Therapeutics, Inc., was granted orphan drug status by the United States Food and Drug Administration for TOL101 (anti-TCR murine monoclonal antibody, type IgM), for treatment of recent onset immune-mediated Type I diabetes mellitus. [Tolera Therapeutics Inc. Press Release]
|
|
POLICY NEWS Hospital Clínic de Barcelona Obtained the First Accreditation for Cell Therapy Research The certification, awarded for the first time in Catalonia, allows the Hospital Clínic de Barcelona to produce drugs in gene therapy, cell therapy and tissue engineering. [Spanish Medicines Agency, Spain] New Videos Reveal How NIH Identifies the Most Promising Research Applications The National Institutes of Health’s Center for Scientific Review released a new video to show new applicants and others how NIH assesses over 80,000 grant applications each year to help find those with the most merit. [National Institutes of Health, United States] NIH and Wellcome Trust Announce Partnership to Support Genomic, Population-Based Studies in Africa The National Institutes of Health (NIH) and the Wellcome Trust announced a partnership with African researchers to conduct genetic and environmental studies in Africa of common, non-communicable disorders, such as heart disease and cancer, as well as communicable diseases, such as malaria. [National Institutes of Health, United States] Publication of New Enforcement Strategy A new enforcement strategy has been published by the Inspection, Enforcement and Standards Division. [Medicines and Healthcare Products Regulatory Agency, United Kingdom] FDA/CDRH Public Meeting: Oversight of Laboratory Developed Tests (LDTs), Date July 19-20, 2010 [Food and Drug Administration, United States] Drugs Designated as Orphan Drugs [Therapeutic Goods Administration, Australia] Therapeutic Goods Committee (TGC) (Updated) [Therapeutic Goods Administration, Australia]
|
|
EVENTS The Second International Conference on Regulatory T Cells and Th17 Cells and Clinical Application in Human Diseases July 17-20, 2010 Shanghai, China Frontiers in Immunology Research (FIRN) 2010 International Conference July 22-26, 2010 Athens, Greece CHI’s 5th Annual Immunotherapeutics and Vaccine Summit (ImVacS) August 17-19, 2010 Cambridge, United States 14th International Congress of Immunology August 22-27, 2010 Kobe, Japan Select Biosciences 3rd Annual Stem Cells Europe Conference August 24-25, 2010 Edinburgh, Scotland Select Biosciences Inaugural Cellular Therapy Summit August 24-25, 2010 Edinburgh, Scotland Select Biosciences 7th Annual RNAi & miRNA Europe September 14-15, 2010 Dublin, Ireland 5th International Conference on Gene Regulation in Lymphocyte Development October 9-14, 2010 Chania, Greece Autumn Immunology Conference 2010 November 19-22, 2010 Chicago, United States Cell Symposia: Influenza – Translating Basic Insights December 2-4, 2010 Washington, D.C., United States Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
JOB OPPORTUNITIES Senior Scientist – Magnetic Cell Separation (STEMCELL Technologies) Business Development Manager Europe – Cell Therapy Products (Pall Corporation) Manager/Sr. Manager, Therapeutic Cell Solutions, Process Development (Lonza) Recruit Top Talent Reach more than 11,000 potential candidates by posting your organization’s career opportunities with Cell Therapy News. Visit here to post your career opportunities.
Have we missed an important article or publication in Immune Regulation News? Click here to submit! Comments or Suggestions? Email info@connexoncreative.com with your feedback.
|
| |
|