Immune Regulation News Volume 2.26 | Jul 16 2010

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    Immune Regulation News 2.26, July 16, 2010.
    In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  EventsSubscribe  |  Unsubscribe


    TOP STORY

    NIH-Led Scientists Find Antibodies that Prevent Most HIV Strains from Infecting Human Cells  ShareThis
    Scientists have discovered two potent human antibodies that can stop more than ninety percent of known global HIV strains from infecting human cells in the laboratory, and have demonstrated how one of these disease-fighting proteins accomplishes this feat. [Press release from the National Institutes of Health discussing online prepublication in Science]

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    SCIENCE NEWS

    Children’s Gut Bacteria Linked to Type I Diabetes
    Researchers have found that the variety of bacteria in a child’s digestive tract is strongly linked to whether that child develops type I diabetes. [Press release from the University of Florida discussing online prepublication in The ISME Journal: Multidisciplinary Journal of Microbial Ecology]

    UF Scientists Discover Clues to Inflammatory Disease
    Through the lens of two inflammation-related diseases, HIV and rheumatoid arthritis, researchers identified changes in specific proteins linked to the action of macrophages. [University of Florida Press Release]

    First Step to New Therapy for Chronic Bowel Disease
    Scientists have discovered that A20 protein plays an important protective role in diseases associated with chronic bowel inflammation. [VIB (Flanders Institute for Biotechnology) Press Release]

    After 40 Years, NIH-Supported Researchers Identify Possible New Treatment for Severe Vasculitis
    Investigators have made a major advance in treating people with a severe form of vasculitis, anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, a rare but devastating disease of blood vessels. [Press release from the National Institute of Allergy and Infectious Diseases discussing online prepublication in The New England Journal of Medicine]

    Researchers Create Tumor-Fighting Immune Cells, Watch in Real Time as They Kill Cancer
    Researchers created a large, well-armed battalion of tumor-seeking immune system cells and used positron emission tomography (PET) to watch in real time as these special forces traveled throughout the body to locate and attack dangerous melanomas. [Press release from the Jonsson Comprehensive Cancer Center discussing online prepublication in Proceedings of the National Academy of Sciences United States of America]

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    CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

    Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis
    Researchers conducted a multicenter, randomized, double-blind, double-dummy, noninferiority trial of rituximab (375 mg per square meter of body-surface area per week for 4 weeks) as compared with cyclophosphamide (2 mg per kilogram of body weight per day) for remission induction. [N Engl J Med]

    Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1
    Researchers used knowledge of HIV-1 envelope (Env) structure to develop antigenically resurfaced glycoproteins specific for the structurally conserved site of CD4 receptor binding. [Science]

    T Cells Expressing the Transcription Factor PLZF Regulate the Development of Memory-Like CD8+ T Cells
    Several gene-deficiency models promote the development of innate CD8+ T cells that have diverse T cell antigen receptors but have a memory phenotype and rapidly produce cytokines. Researchers demonstrate here that similar cells developed in mice deficient in the transcription factor KLF2. [Nat Immunol]

    Type I Interferons Regulate Cytolytic Activity of Memory CD8+ T Cells in the Lung Airways During Respiratory Virus Challenge
    Here, researchers demonstrate that although airway-resident memory CD8+ T cells were poorly cytolytic, memory CD8+ T cells recruited to the airways early during a recall response showed markedly enhanced cytolytic ability. [Immunity]

    Repetitive Antigen Stimulation Induces Stepwise Transcriptome Diversification but Preserves a Core Signature of Memory CD8+ T Cell Differentiation
    Here researchers showed that repetitive antigen stimulations induced accumulation of memory CD8+ T cells with uniform effector memory characteristics. [Immunity]

    K33-Linked Polyubiquitination of T Cell Receptor-Zeta Regulates Proteolysis-Independent T Cell Signaling
    Researchers describe that in mice deficient in the E3 ubiquitin ligases Cbl-b and Itch, T cell activation was augmented, accompanied by spontaneous autoimmunity. [Immunity]

    Kinetic Phases of Distribution and Tumor Targeting by T Cell Receptor Engineered Lymphocytes Inducing Robust Antitumor Responses
    Adoptive cell transfer of splenocytes from fully immunocompetent HLA-A2.1/Kb mice transduced with a chimeric murine/human T cell receptor specific for tyrosinase, together with lymphodepletion conditioning, dendritic cell-based vaccination, and high-dose interleukin-2, had profound antitumor activity against large established MHC- and antigen-matched tumors. [Proc Natl Acad Sci U S A]

    Toward Defining the Autoimmune Microbiome for Type I Diabetes
    High-throughput, culture-independent approaches identified bacteria that correlate with the development of type I diabetes-associated autoimmunity in young children who are at high genetic risk for this disorder. [ISME J]

    CD30 Discriminates Heat Shock Protein 60-Induced FOXP3+CD4+ T Cells with a Regulatory Phenotype
    In this study, researchers demonstrate that highly suppressive FOXP3+ regulatory T cells can be induced in vitro by the activation of CD4+CD25- T cells with the self-antigen human 60-kDa heat shock protein. [J Immunol]

    Regulatory B Cells (B10 Cells) and Regulatory T Cells Have Independent Roles in Controlling Experimental Autoimmune Encephalomyelitis Initiation and Late-Phase Immunopathogenesis
    This study demonstrates that the number of endogenous or adoptively transferred B10 cells directly influenced experimental autoimmune encephalomyelitis pathogenesis through their production of IL-10. [J Immunol]


    INDUSTRY NEWS

    RegeneRx Awarded Australian Patent for New TB4 Applications
    RegeneRx Biopharmaceuticals, Inc. announced it has received Notice of Acceptance from the Australian patent office for the use of Thymosin beta 4 (TB4), its analogues, isoforms and other derivatives in the treatment of infections and inflammatory disorders including colitis, ileitis, gastrointestinal ulcers and gingivitis, among others. [RegeneRx Biopharmaceuticals, Inc. Press Release]

    UK Biopharmaceutical Company Will be Built Based on Human Monoclonal Antibody Technology from the Sanger Institute
    Kymab and The Wellcome Trust investment division announced a 20 million (pounds) Series A equity financing. [Wellcome Trust Sanger Institute Press Release]


    POLICY NEWS

    Harold Varmus Sworn in as National Cancer Institute’s 14th Director
    Nobel Prize winner Harold E. Varmus, M.D., took the oath of office to become the National Cancer Institute’s (NCI) 14th director. NCI is one of the 27 Institutes and Centers that comprise the National Institutes of Health (NIH). [National Institutes of Health, United States]

    Britain Delays Controversial Assessment Scheme for Research
    Britain’s new science minister made good a manifesto pledge when he announced that the coalition government would delay for one year the implementation of the controversial Research Excellence Framework, a system of assessing university departments for the distribution of funding. [Ministry of Universities and Science, United Kingdom]

    Spanish Science Spending Lockdown
    Spain’s science and innovation minister said that research funding will be “frozen or minimally reduced” as a result of government-wide austerity measures. [Ministry of Science and Innovation, Spain]

    Clinical Laboratory Improvement Advisory Committee (CLIAC); Notice of Meeting [Centers for Disease Control and Prevention, United States]

    Request for Information (RFI) on the National Institutes of Health Plan to Develop the Genetic Testing Registry; Notice [National Institutes of Health, United States]

    Eunice Kennedy Shriver National Institute of Child Health and Human Development; Notice of Closed Meeting [National Institutes of Health, United States]

    National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting [National Institutes of Health, United States]

    Notice of Intent to Publish a Request for Applications for Tumor Microenvironment Network (TMEN) (NOT-CA-10-032) [National Institutes of Health, United States]


    EVENTS

    Frontiers in Immunology Research (FIRN) 2010 International Conference
    July 22-26, 2010
    Athens, Greece

    CHI’s 5th Annual Immunotherapeutics and Vaccine Summit (ImVacS)
    August 17-19, 2010
    Cambridge, United States

    14th International Congress of Immunology
    August 22-27, 2010
    Kobe, Japan

    Select Biosciences 3rd Annual Stem Cells Europe Conference
    August 24-25, 2010
    Edinburgh, Scotland

    Select Biosciences Inaugural Cellular Therapy Summit
    August 24-25, 2010
    Edinburgh, Scotland

    Select Biosciences 7th Annual RNAi & miRNA Europe
    September 14-15, 2010
    Dublin, Ireland

    Immunology & Microbiology, Genetics & Genomics, Development, Other
    September 18-22, 2010
    Barcelona, Spain

    Cell Symposia: Inflammation and Disease
    September 26-28, 2010
    Lisbon, Portugal

    11th International Symposium on Dendritic Cells in Fundamental and Clinical Immunology – DC2010: Forum on Vaccine Science
    September 26-30, 2010
    Lugano, Switzerland

    5th International Conference on Gene Regulation in Lymphocyte Development
    October 9-14, 2010
    Chania, Greece

    Autumn Immunology Conference 2010
    November 19-22, 2010
    Chicago, United States

    Cell Symposia: Influenza – Translating Basic Insights
    December 2-4, 2010
    Washington, D.C., United States

    Visit our events page  to stay up to date with the latest events in the cell, gene and immunotherapy community.


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