CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) Confinement-Optimized Three-Dimensional T Cell Amoeboid Motility is Modulated via Myosin IIA-Regulated Adhesions Here, researchers show that in vivo, myosin IIA-deficient T cells had a triad of defects, including overadherence to high-endothelial venules, less interstitial migration and inefficient completion of recirculation through lymph nodes. [Nat Immunol] Human CD14dim Monocytes Patrol and Sense Nucleic Acids and Viruses via TLR7 and TLR8 Receptors Here, researchers have characterized the functions of human monocytes that lack CD14 (CD14dim) and express CD16. CD14dim monocytes were genetically distinct from natural killer cells. [Immunity] Immunodominant T Cell Responses to Dengue Virus NS3 are Associated with DHF In this study, researchers set out to study T cell responses across the entire dengue virus proteome and to see whether these were related to disease severity in a cohort of dengue-infected children from Thailand. [Proc Natl Acad Sci USA] Shared Molecular Amino Acid Signature in the HLA-DR Peptide Binding Pocket Predisposes to Both Autoimmune Diabetes and Thyroiditis Type IA diabetes (T1D) and autoimmune thyroid disease (AITD) frequently occur together in the same individual, a condition classified as a variant of the autoimmune polyglandular syndrome type 3 (APS3). Because T1D and AITD are individually strongly associated with different HLA class II sequences, researchers asked which HLA class II pocket sequence and structure confer joint susceptibility to both T1D and AITD in the same individual (APS3v). [Proc Natl Acad Sci USA] Chemotherapy-Induced Genotoxic Stress Promotes Sensitivity to Natural Killer Cell Cytotoxicity by Enabling Missing-Self Recognition Here, researchers show that Clr-b is rapidly downregulated in cells undergoing genotoxic and cellular stress at the level of both RNA and surface protein. [Cancer Res] T Cells Expressing Constitutively Active Akt Resist Multiple Tumor-associated Inhibitory Mechanisms Constitutively active Akt-transduced T cells showed resistance to several evasion strategies employed by tumors and may therefore enhance the antitumor activity of adoptively transferred T lymphocytes. [Mol Ther] Combined Administration of a Mutant TGF-Beta1/Fc and Rapamycin Promotes Induction of Regulatory T Cells and Islet Allograft Tolerance In this study, researchers report the development of a long-lasting autoactive human mutant TGF-beta1/Fc fusion protein that acts in conjunction with rapamycin to inhibit T cell proliferation and induce the de novo generation of Foxp3+ regulatory T cell in the periphery, while at the same time inhibiting IL-6-mediated Th17 cell differentiation. [J Immunol] TLR Agonists that Induce IFN-Beta Abrogate Resident Macrophage Suppression of T Cells The results suggest TLR agonists that activate TRIF, and consequently induce IFN-beta, but not those that exclusively signal through MyD88, abrogate the immunosuppressive properties of resident tissue macrophages, and thus promote T cell expansion and elimination of invading microorganisms. [J Immunol] | |
POLICY NEWS NIH Expands Network Focused on How Genes Affect Drug Responses [National Institutes of Health, United States] National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting (FR Doc. 2010-22327) [National Institutes of Health, United States] National Center for Research Resources; Notice of Closed Meetings (FR Doc. 2010-22529) [National Institutes of Health, United States] Notice of Correction: Application Due Date for RFA-HG-10-012, Revolutionary Genome Sequencing Technologies – The $1000 Genome (R01) and RFA-HG-10-013, Revolutionary Genome Sequencing Technologies – The $1000 Genome (R21) (Notice Number:NOT-HG-10-021) [National Institutes of Health, United States] Knockout Mouse Production and Cryopreservation (U42) (RFA-RM-10-013) [National Institutes of Health, United States] Knockout Mouse Phenotyping Project Database (U54) (RFA-RM-10-012) [National Institutes of Health, United States] Knockout Mouse Phenotyping (U54) (RFA-RM-10-011) [National Institutes of Health, United States] Enhancing Peer Review: Reminder of and Correction to Previous Notice on A2 Resubmission Opportunities for Eligible Applications (NOT-OD-10-135) [National Institutes of Health, United States] Notice of Correction to RFA-AG-11-010, Basic Research on Self-Regulation (R21) (NOT-AG-10-011) [National Institutes of Health, United States] Agenda for the Public Workshop on Cell and Gene Therapy Clinical Trials in Pediatric Populations [Food and Drug Administration, United States]
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EVENTS (Listed by Date) Immunology & Microbiology, Genetics & Genomics, Development, Other September 18-22, 2010 Barcelona, Spain Cell Symposia: Inflammation and Disease September 26-28, 2010 Lisbon, Portugal 11th International Symposium on Dendritic Cells in Fundamental and Clinical Immunology – DC2010: Forum on Vaccine Science September 26-30, 2010 Lugano, Switzerland 5th International Conference on Gene Regulation in Lymphocyte Development October 9-14, 2010 Chania, Greece Autumn Immunology Conference 2010 November 19-22, 2010 Chicago, United States Cell Symposia: Influenza – Translating Basic Insights December 2-4, 2010 Washington, D.C., United States
Phacilitate’s 7th Annual Cell & Gene Therapy Forum January 24-26, 2011 Washington DC, United States Keystone Symposia: Dendritic Cells and the Initiation of Adaptive Immunity joint with Cancer Control by Tumor Suppressors and Immune Effectors February 12-17, 2011 Santa Fe, United States Keystone Symposia: Genetics, Immunology and Repair in Multiple Sclerosis February 15-20, 2011 Taos, United States The 6th International Conference on Oncolytic Viruses As Cancer Therapeutics March 16-19, 2011 Las Vegas, United States NEW Microbiota and Mucosal Immunology: The Interface in Health and Disease April 14-16, 2011 San Francisco, United States American Society of Gene and Cell Therapy (ASGCT) 14th Annual Meeting May 18-22, 2011 Seattle, United States Gordon Research Conferences: Viruses & Cells May 29-June 3, 2011 Lucca, Italy Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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