SCIENCE NEWS
Mice Engrafted with Human Immune Cells May Provide Clues to Better Prevention and Treatment of Typhoid Fever
Better treatments and prevention for typhoid fever may emerge from a laboratory model that has just been developed for the disease. The model is based on transplanting human immune stem cells from umbilical cord blood into mice that are susceptible to infections. [Press release from the University of Washington discussing online prepublication in Proceedings of the National Academy of Sciences USA]
Bacteria Identified That May Lead to Inflammatory Bowel Disease in Genetically Susceptible Individuals
Certain bacteria that inhabit the intestine provide the environmental trigger that initiates and perpetuates chronic intestinal inflammation in individuals who are genetically susceptible to inflammatory bowel disease, a study has found. [Press release from Harvard School of Public Health discussing online prepublication in Cell Host & Microbe]
Discovery Highlights Promise of New Immune System-Based Therapies
A new focus on the immune system’s ability to both unleash and restrain its attack on disease has led scientists to identify cells in mice that prevent the immune system from attacking the animals’ own cells, protecting them from autoimmune diseases such as multiple sclerosis, type I diabetes, and lupus. [Press release from the Dana-Farber Cancer Institute discussing online prepublication in Nature]
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)
Inhibition of Follicular T Helper Cells by CD8+ Regulatory T Cells is Essential for Self Tolerance
Here, researchers delineate a CD8+ regulatory T cell lineage that is essential for the maintenance of self tolerance and prevention of murine autoimmune disease. [Nature]
The S1P1-mTOR Axis Directs the Reciprocal Differentiation of TH1 and Treg Cells
Researchers found that the differentiation of proinflammatory T helper type 1 cells and anti-inflammatory Foxp3+ regulatory T cells was reciprocally regulated by S1P1, a receptor for the bioactive lipid sphingosine 1-phosphate. [Nat Immunol]
The Transcription Factor PU.1 Controls Dendritic Cell Development and Flt3 Cytokine Receptor Expression in a Dose-Dependent Manner
Here, researchers showed that the transcription factor PU.1 (encoded by Sfpi1) was essential for dendritic cell (DC) development in vivo and that conditional ablation of PU.1 in defined precursors, including the common DC progenitor, blocked Flt3 ligand-induced DC generation in vitro. [Immunity]
Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses
Here, researchers report that miR-146a, one of the miRNAs prevalently expressed in regulatory T cells, is critical for their suppressor function. [Immunity]
Scid IL2r-Gamma-Null Mice are Susceptible to Lethal Salmonella Typhi Infection”>Humanized Nonobese Diabetic-scid IL2r-Gamma-Null Mice are Susceptible to Lethal Salmonella Typhi Infection
Here, researchers show that S. Typhi can replicate in vivo in nonobese diabetic-scid IL2r-gamma-null mice engrafted with human hematopoietic stem cells (hu-SRC-SCID mice) to cause a lethal infection with pathological and inflammatory cytokine responses resembling human typhoid. [Proc Natl Acad Sci USA]
Promoting Tolerance to Proteolipid Protein-Induced Experimental Autoimmune Encephalomyelitis through Targeting Dendritic Cells
Here, researchers report that anti-DEC205-mediated delivery of the self-peptide proteolipid protein (PLP)139-151 to dendritic cells ameliorated clinical symptoms in the PLP-induced SJL model of experimental autoimmune encephalomyelitis. [Proc Natl Acad Sci USA]
Cutting Edge: NLRP12 Controls Dendritic and Myeloid Cell Migration to Affect Contact Hypersensitivity
Researchers found that murine Nlrp12 , a nucleotide-binding domain leucine-rich repeat linked to atopic dermatitis and hereditary periodic fever in humans, is prominently expressed in dendritic cells and neutrophils. [J Immunol]
Soluble CD93 Induces Differentiation of Monocytes and Enhances TLR Responses
In the current study, researchers analyzed the functional effects of a soluble form of CD93 on THP-1 monocytic cells and human primary monocytes. [J Immunol]
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INDUSTRY NEWS
OncoMethylome Sciences Signs Agreement for the Potential Use of Its Technology Platform in GlaxoSmithKline Biologicals Immunotherapy Development Program
OncoMethylome Sciences announced that it has entered into an agreement with GlaxoSmithKline Biologicals S.A. (GSK) for the potential use of one of its DNA methylation specific PCR biomarkers in GSKs immunotherapy development program. [OncoMethylome Sciences Press Release]
ProtoKinetix in Partnership Discussions with Diabetes Specific Foundations and Research Organizations
ProtoKinetix Inc., over the last several weeks, has been in discussions with several diabetes specific organizations with a view to testing in two key areas in the treatment of diabetes. [ProtoKinetix Inc. Press Release]
Anthera Pharmaceuticals Announces Pricing of $31.5 Million PIPE Financing
Anthera Pharmaceuticals, Inc. announced that it has entered into definitive agreements with certain accredited investors in connection with a private placement, or PIPE, financing transaction pursuant to Section 4(2) of the Securities Act of 1933, as amended, and Regulation D promulgated thereunder. [Anthera Pharmaceuticals, Inc. Press Release]
Novartis Gains FDA Approval for Gilenya(TM), A Novel First-Line Multiple Sclerosis Treatment Shown to Significantly Reduce Relapses and Delay Disability Progression
Novartis announced that the US Food and Drug Administration approved the oral multiple sclerosis treatment Gilenya(TM) (fingolimod) 0.5 mg daily, a first-line treatment for relapsing forms of multiple sclerosis – the most common forms of the disease. [Novartis Press Release]
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EVENTS (Listed by Date)
Cell Symposia – Inflammation and Disease
September 26-28, 2010
Lisbon, Portugal
11th International Symposium on Dendritic Cells in Fundamental and Clinical Immunology – DC2010: Forum on Vaccine Science
September 26-30, 2010
Lugano, Switzerland
NEW American Society for Histocompatibility & Immunogenetics 36th Annual Meeting
September 26-30, 2010
Hollywood, United States
NEW Cytokines 2010: Cytokines in Infectious Diseases, Autoimmune Disorders and Cancer
October 3-7, 2010
Chicago, United States
5th International Conference on Gene Regulation in Lymphocyte Development
October 9-14, 2010
Chania, Greece
NEW The 8th Asia Pacific Congress of Allergy, Asthma and Clinical Immunology
November 7-10, 2010
Singapore
NEW 2010 Annual Meeting of the American College of Allergy, Asthma & Immunology
November 11-16, 2010
Phoenix, United States
39th Autumn Immunology Conference
November 19-22, 2010
Chicago, United States
Cell Symposia: Influenza – Translating Basic Insights
December 2-4, 2010
Washington, D.C., United States
NEW The 50th Midwinter Conference of Immunologists at Asilomar
January 22-25, 2011
Pacific Grove, United States
Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington, DC, United States
NEW Phacilitate 9th Annual North American Vaccine Forum
January 24-26, 2011
Washington, DC, United States
Keystone Symposia: Dendritic Cells and the Initiation of Adaptive Immunity joint with Cancer Control by Tumor Suppressors and Immune Effectors
February 12-17, 2011
Santa Fe, United States
Keystone Symposia: Genetics, Immunology and Repair in Multiple Sclerosis
February 15-20, 2011
Taos, United States
NEW BMT Tandem Meetings (ASBMT/CIBMTR)
February 17-21, 2011
Honolulu, Hawaii
NEW 18th Conference on Retroviruses and Opportunistic Infections (CROI 2011)
February 27-March 2, 2011
Boston, United States
The 6th International Conference on Oncolytic Viruses as Cancer Therapeutics
March 16-19, 2011
Las Vegas, United States
NEW 2011 American Academy of Allergy, Asthma and Immunology (AAAAI) Annual Meeting
March 18-22, 2011
San Francisco, United States
Microbiota and Mucosal Immunology: The Interface in Health and Disease
April 14-16, 2011
San Francisco, United States
NEW GTCbio: 2nd International Conference on Cancer Immunotherapy & Immunomonitoring
May 2-5, 2011
Budapest, Hungary
American Society of Gene and Cell Therapy (ASGCT) 14th Annual Meeting
May 18-22, 2011
Seattle, United States
Gordon Research Conference: Viruses & Cells
May 29-June 3, 2011
Lucca (Barga), Italy
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