SCIENCE NEWS Cell Survival Protein Discovery Rewrites Immune System Story A discovery is set to rewrite a long-held belief about how the body’s immune system establishes its memory. [Press release from the Walter and Eliza Hall Institute discussing online prepublication in Science] Studying Illnesses Caused by Worms Biomedical researchers are investigating illnesses caused by these gut-dwelling worms in an effort to decipher how immune cells send and receive signals that determine the specific immune response to mount. [Press release from the Trudeau Institute discussing online prepublication in the Journal of Immunology] UT Southwestern Study to Determine Whether Leptin Helps Type I Diabetes Patients A clinical trial aims to determine whether adding the hormone leptin to standard insulin therapy might help rein in the tumultuous blood-sugar levels of people with type I diabetes. [The University of Texas Southwestern Medical Center Press Release]
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) The Structural Basis for Autonomous Dimerization of the Pre-T Cell Antigen Receptor The pre-T-cell antigen receptor (pre-TCR) comprises an invariant alpha-chain (pre-Talpha) that pairs with any TCR beta-chain (TCRbeta) following successful TCR beta-gene rearrangement. The unusual dual-chaperone-like sensing function of pre-Talpha represents a unique mechanism in nature whereby developmental quality control regulates the expression and signalling of an integral membrane receptor complex. [ Nature] Mcl-1 is Essential for Germinal Center Formation and B Cell Memory Here, researchers investigated the consequences of deleting genes encoding the anti-apoptotic molecules Mcl1 and Bcl2l1 from B cells using an inducible system synchronized with expression of activation-induced cytidine deaminase following immunization. [Science] Structures of the CXCR4 Chemokine G Protein-Coupled Receptor With Small-Molecule and Cyclic Peptide Antagonists Here, researchers report five independent crystal structures of CXCR4 bound to an antagonist small molecule IT1t and a cyclic peptide CVX15 at 2.5 to 3.2 angstrom resolution. [Science] IL-12 Initiates Tumor Rejection via Lymphoid Tissue-Inducer Cells Bearing the Natural Cytotoxicity Receptor NKp46 By systematic analysis of the IL-12-induced immune response to subcutaneous melanoma (B16), researchers found that tumor suppression was mediated independently of T lymphocytes or natural killer cells. [Nat Immunol] IL-37 is a Fundamental Inhibitor of Innate Immunity Expression of IL-37 in macrophages or epithelial cells almost completely suppressed production of pro-inflammatory cytokines, whereas the abundance of these cytokines increased with silencing of endogenous IL-37 in human blood cells. [Nat Immunol] The microRNA miR-182 Is Induced by IL-2 and Promotes Clonal Expansion of Activated Helper T Lymphocytes Here, researchers show that in the late phase of expansion, Foxo1 was no longer post-translationally regulated but was inhibited post-transcriptionally by the interleukin 2 (IL-2)-induced microRNA miR-182. [Nat Immunol] Early B Cell Factor 2 Regulates Hematopoietic Stem Cell Homeostasis in a Cell-Nonautonomous Manner Here, researchers examine the role of early B cell factor 2 (Ebf2), a transcription factor expressed in a subset of immature osteoblastic cells. Ebf2-/- mice show decreased frequencies of hematopoietic stem cells and lineage-committed progenitors. [Cell Stem Cell] Intravital Imaging Reveals Distinct Dynamics for Natural Killer and CD8+ T Cells during Tumor Regression To address how NKG2D engagement affects intratumoral natural killer cell dynamics, researchers performed intravital microscopy in a Rae-1beta-expressing solid tumor. [Immunity] Early Lymphocyte Recovery Following Intensive Timed Sequential Chemotherapy for Acute Myelogenous Leukemia: Peripheral Oligoclonal Expansion of Regulatory T Cells To test the hypothesis that lymphocyte recovery mirrors ontogeny, researchers characterized early lymphocyte recovery and attendant cytokine profiles in twenty consecutive patients undergoing induction timed sequential chemotherapy for newly diagnosed acute myelogenous leukemia. [Blood] A Nonredundant Role for IL-21 Receptor Signaling in Plasma Cell Differentiation and Protective Type 2 Immunity Against Gastrointestinal Helminth Infection In the present study, researchers identify IL-21R signaling as a critical factor in driving pathogen-specific plasma cell differentiation and protective immunity against H. polygyrus in mice. [J Immunol]
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INDUSTRY NEWS ImmunoCellular Therapeutics’ Clinical Data for ICT-107 Featured at World Stem Cell Summit ImmunoCellular Therapeutics, a biotechnology company focused on the development of novel immune-based cancer therapies, announced that the company’s clinical data from ICT-107 will be featured in two oral sessions at the World Stem Cell Summit. [ImmunoCellular Therapeutics, Ltd. Press Release] Micromet Announces FDA Acceptance of Investigational New Drug Application for BiTE Antibody MT111/MEDI-565 Micromet, Inc. announced that its licensee for MT111, MedImmune, plans to initiate a Phase I trial in patients with advanced gastrointestinal cancers based on an investigational new drug application recently accepted by the U.S. Food and Drug Administration (FDA). MT111, also known as MEDI-565, is a BiTE(R) antibody designed to direct a patient’s T cells against cancer cells that express carcinoembryonic antigen. [Micromet, Inc. Press Release] U.S. Food and Drug Administration Approves Aridol Pharmaceutical company Pharmaxis is pleased to announce the U.S. Food and Drug Administration has approved Aridol™ (mannitol inhalation powder) Bronchial Challenge Test Kit for marketing. [Pharmaxis Ltd. Press Release] STEMSOFT Connect – A Simplified Solution to a Complex Problem STEMSOFT is pleased to announce the release of their new standard interfaces, STEMSOFT Connect™. STEMSOFT Connect offers standard interface tools that easily connect commonly used applications and devices to STEMSOFT’s applications. [STEMSOFT Software Inc. Press Release]
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POLICY NEWS NIH Funds Advanced Development of Three Biodefense Vaccines The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, announced three new contracts to fund research on vaccines to protect against emerging infectious diseases and biological threats that could be used in a terror attack. [National Institutes of Health, United States] NIH Announces New Program to Accelerate Research Independence The National Institutes of Health intends to invest approximately $60 million over the next five years in the NIH Director’s Early Independence Award program to help junior investigators leapfrog over traditional post-doctoral training and move into independent academic positions at U.S. institutions, directly upon completion of their graduate research degrees. [National Institutes of Health, United States] NIH Launches Genotype-Tissue Expression Project The National Institutes of Health (NIH) announced awards to support an initiative to understand how genetic variation may control gene activity and its relationship to disease. Launched as a pilot phase, the Genotype-Tissue Expression (GTEx) project will create a resource researchers can use to study inherited susceptibility to illness and will establish a tissue bank for future biological studies. [National Institutes of Health, United States] FDA’s $25 Million Pitch for Improving Drug Regulation The U.S. Food and Drug Administration (FDA) is pressing for a big funding boost for “regulatory science”- research that can help it evaluate new treatments better and faster. [Food and Drug Administration, United States] FDA to Push for More Investment in Science Health regulators plan to spend millions of dollars to step up their scientific prowess in a move that officials say will help quickly get new treatments to patients and protect the public against possible health threats. [Food and Drug Administration, United States] FDA Issues Regulatory Science Report The U.S. Food and Drug Administration unveiled a report outlining the agency’s plans to advance regulatory science through its Regulatory Science Initiative. [Food and Drug Administration, United States] Plan to Develop a Genetic Testing Registry at the National Institutes of Health; Public Meeting; Request for Comments (FR Doc. 2010-25411) [National Institutes of Health, United States] Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2010-25171) [National Institutes of Health, United States] Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-25180) [National Institutes of Health, United States] Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-25185) [National Institutes of Health, United States]
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EVENTS (Listed by Date) The 8th Asia Pacific Congress of Allergy, Asthma and Clinical Immunology November 7-10, 2010 Singapore 2010 Annual Meeting of the American College of Allergy, Asthma & Immunology November 11-16, 2010 Phoenix, United States 39th Autumn Immunology Conference November 19-22, 2010 Chicago, United States NEW Tumor Immunology: Basic and Clinical Advances November 30-December 3, 2010 Miami, United Sates Cell Symposia: Influenza – Translating Basic Insights December 2-4, 2010 Washington, D.C., United States NEW 5th Annual Stem Cell Meeting on the Mesa December 7, 2010 La Jolla, United States The 50th Midwinter Conference of Immunologists at Asilomar January 22-25, 2011 Pacific Grove, United States Phacilitate 7th Annual Cell & Gene Therapy Forum 2011 January 24-26, 2011 Washington, DC, United States Phacilitate 9th Annual North American Vaccine Forum January 24-26, 2011 Washington, DC, United States NEW AACR-ACS Joint Meeting on Chemistry in Cancer Research: The Biological Chemistry of Inflammation as a Cause of Cancer January 30-February 2, 2011 San Diego, United Sates Keystone Symposia: Dendritic Cells and the Initiation of Adaptive Immunity joint with Cancer Control by Tumor Suppressors and Immune Effectors February 12-17, 2011 Santa Fe, United States Keystone Symposia: Genetics, Immunology and Repair in Multiple Sclerosis February 15-20, 2011 Taos, United States BMT Tandem Meetings (ASBMT/CIBMTR) February 17-21, 2011 Honolulu, Hawaii 18th Conference on Retroviruses and Opportunistic Infections (CROI 2011) February 27-March 2, 2011 Boston, United States The 6th International Conference on Oncolytic Viruses as Cancer Therapeutics March 16-19, 2011 Las Vegas, United States 2011 American Academy of Allergy, Asthma and Immunology (AAAAI) Annual Meeting March 18-22, 2011 San Francisco, United States Microbiota and Mucosal Immunology: The Interface in Health and Disease April 14-16, 2011 San Francisco, United States GTCbio: 2nd International Conference on Cancer Immunotherapy & Immunomonitoring May 2-5, 2011 Budapest, Hungary American Society of Gene and Cell Therapy (ASGCT) 14th Annual Meeting May 18-22, 2011 Seattle, United States Gordon Research Conference: Viruses & Cells May 29-June 3, 2011 Lucca (Barga), Italy Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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