TOP STORY NIH Scientists Discover Secrets of Helper T Cells Involved in Autoimmunity Scientists have redefined the roles of several cytokines involved in the generation of immune cells implicated in severe autoimmune diseases. The study in mice showed that development of Th17 immune cells can occur without the presence of transforming growth factor-beta, a mediator thought to be required for Th17 cell development. [Press release from the National Institutes of Health discussing online prepublication in Nature]
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SCIENCE NEWS Novel Regulatory Process for T Cells May Help Explain Immune System Diseases A newly identified regulatory process affecting the biology of immune system T cells should give scientists new approaches to explore the causes of autoimmunity and immune deficiency diseases. [Press release from the Cincinnati Children’s Hospital Medical Center discussing online prepublication in the Proceedings of the National Academy of Sciences USA] Elusive Protein May Lead the Fight Against Inflammatory Disease A research team has identified a protein that may be a key therapy for many inflammatory diseases, including those affecting premature babies. [Press release from the Monash Institute of Medical Research discussing online prepublication in Nature Immunology]
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) Generation of Pathogenic TH17 Cells in the Absence of TGF-Beta Signalling Here, researchers show that TH17 differentiation can occur in the absence of TGF-beta signalling. [Nature] IL-37 is a Fundamental Inhibitor of Innate Immunity Expression of IL-37 in macrophages or epithelial cells almost completely suppressed production of pro-inflammatory cytokines, whereas the abundance of these cytokines increased with silencing of endogenous IL-37 in human blood cells. [Nat Immunol] IL-35-Mediated Induction of a Potent Regulatory T Cell Population Here, researchers show that treatment of naive human or mouse T cells with IL-35 induced a regulatory population, which researchers call ‘iTR35 cells’, that mediated suppression via IL-35 but not via the inhibitory cytokines IL-10 or transforming growth factor-beta. [Nat Immunol] Intravital Imaging Reveals Distinct Dynamics for Natural Killer and CD8+ T Cells During Tumor Regression Recognition of NKG2D ligands by natural killer (NK) cells plays an important role during antitumoral responses. To address how NKG2D engagement affects intratumoral NK cell dynamics, researchers performed intravital microscopy in a Rae-1beta-expressing solid tumor. [Immunity] Histone Deacetylase Inhibitors Impair Innate Immune Responses to Toll-Like Receptor Agonists and to Infection Here, researchers describe the effects of histone deacetylase inhibitors on microbial sensing by macrophages and dendritic cells in vitro and host defenses against infection in vivo. [Blood] Bortezomib Suppresses Function and Survival of Plasmacytoid Dendritic Cells by Targeting Intracellular Trafficking of Toll-Like Receptors and Endoplasmic Reticulum Homeostasis Here, researchers show that a proteasome inhibitor bortezomib suppresses survival and immunostimulatory function of human plasmacytoid dendritic cells by targeting two critical points, intracellular trafficking of nucleic acid-sensing Toll-like receptors and endoplasmic reticulum homeostasis. [Blood] Coordination of IL-7 Receptor and T Cell Receptor Signaling By Cell-Division Cycle 42 in T Cell Homeostasis Here, researchers demonstrate that T cell-specific deletion of cell-division cycle 42 (Cdc42) GTPase causes a profound loss of mature T cells. [Proc Natl Acad Sci USA] T Cell Receptor-Driven Lymphomagenesis in Mice Derived from a Reprogrammed T Cell The lymphomagenesis in mice derived from a reprogrammed T cell demonstrates the deleterious consequences of misregulation of the T cell receptor rearrangement and signaling pathways and illustrates one case of cellular reprogramming where the identity of the cell of origin has profound consequences. [Proc Natl Acad Sci USA] The Adapters EAT-2A and -2B Are Positive Regulators of CD244- and CD84-Dependent NK Cell Functions in the C57BL/6 Mouse To evaluate whether the genetic background or the presence of a selection marker in the mutant mice could influence the regulatory mode of these adapters, researchers generated EWS/FLI1-activated transcript (EAT)-2A-, EAT-2B-, and EAT-2A/B-deficient mice using C57BL/6 embryonic stem cells. [J Immunol] On How Monospecific Memory-Like Autoregulatory CD8+ T Cells Can Blunt Diabetogenic Autoimmunity: A Computational Approach Here, researchers examine the dynamics of memory autoregulatory CD8+ T cells specific for islet-specific glucose-6-phosphatase catalytic subunit-related protein(206-214), a prevalent beta cell autoantigen; their high-avidity counterparts (dominant effectors); and all other autoreactive non-islet-specific glucose-6-phosphatase catalytic subunit-related protein(206-214)-specific CD8+ T cell specificities (subdominant effectors) in response to peptide-major histocompatibility complex-coated nanoparticle therapy. [J Immunol]
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POLICY NEWS European Medicines Agency Strengthens Rules on Conflicts of Interests of Its Scientific Experts The European Medicines Agency has published new rules on how the Agency will be handling potential conflicts of interests of its scientific experts, following endorsement by its Management Board. [European Medicines Agency, European Union] IQWiG: Law Must Prescribe Obligation to Publish All Clinical Trials If the currently discussed draft on the “Law on the Reorganization of the Pharmaceutical Market” (AMNOG) is implemented, drug manufacturers will in future have to register their clinical trials at inception and publish results after completion. [Institute for Quality and Efficiency in Health Care (IQWiG), Germany] Loss of UK Genetics Public Bodies Confirmed The official announcement from the UK Government on the future of non-departmental public bodies has confirmed the rumored abolition of a total of 192 public bodies, with a further 118 to be merged. [Foundation for Genomics and Population Health, United Kingdom] HHS to Let Secretary’s Genetics Committee Expire The Secretary’s Advisory Committee on Genetics, Health, and Society will disband next month, eight years after its founding. The committee had completed its original task, advising the Department of Health and Human Services (HHS) on a number of issues related to genomics. [Department of Health and Human Services, United States] Screening Framework Guidance for Providers of Synthetic Double-Stranded DNA (FR Doc. 2010-25728) [Department of Health and Human Services, United States] Proposed Collection; Comment Request; National Evaluation of the Clinical and Translational Science Awards (CTSA) Initiative (FR Doc. 2010-25589) [Department of Health and Human Services, United States] Agency Information Collection Request. 30-Day Public Comment Request (FR Doc. 2010-25587) [Department of Health and Human Services, United States] Partnerships To Advance the National Occupational Research Agenda (NORA) (FR Doc. 2010-25973) [Centers for Disease Control and Prevention, United States] Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc. 2010-26036) [National Institutes of Health, United States] National Human Genome Research Institute; Notice of Closed Meeting (FR Doc. 2010-25634) [National Institutes of Health, United States] Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-25595) [National Institutes of Health, United States] Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-25597) [National Institutes of Health, United States] Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2010-25598) [National Institutes of Health, United States] Center for Scientific Review; Amended Notice of Meeting (FR Doc. 2010-25601) [National Institutes of Health, United States] Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26028) [National Institutes of Health, United States] Center for Scientific Review; Notice of Closed Meetings (FR Doc. 2010-26033) [National Institutes of Health, United States] National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-25636) [National Institutes of Health, United States] National Cancer Institute; Notice of Closed Meeting (FR Doc. 2010-25640) [National Institutes of Health, United States] National Cancer Institute; Notice of Meeting (FR Doc. 2010-26032) [National Institutes of Health, United States] National Cancer Institute; Notice of Closed Meetings (FR Doc. 2010-26035) [National Institutes of Health, United States] National Institute of General Medical Sciences; Notice of Closed Meeting (FR Doc. 2010-26037) [National Institutes of Health, United States] National Institute of General Medical Sciences; Notice of Closed Meeting (FR Doc. 2010-26075) [National Institutes of Health, United States]
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EVENTS (Listed by Date) The 8th Asia Pacific Congress of Allergy, Asthma and Clinical Immunology November 7-10, 2010 Singapore GTCbio 8th Annual Vaccines: “All Things Considered” Conference November 8-9, 2010 Washington, D.C., United States 2010 Annual Meeting of the American College of Allergy, Asthma & Immunology November 11-16, 2010 Phoenix, United States Understanding Dendritic Cells and Their Ability to Regulate Immune Responses November 12, 2010 Hertfordshire, United Kingdom 39th Autumn Immunology Conference November 19-22, 2010 Chicago, United States American Association for Cancer Research (AACR): Tumor Immunology – Basic and Clinical Advances November 30-December 3, 2010 Miami, United States Cell Symposia: Influenza – Translating Basic Insights December 2-4, 2010 Washington, D.C., United States 5th Annual Stem Cell Meeting on the Mesa December 7, 2010 La Jolla, United States The 50th Midwinter Conference of Immunologists at Asilomar January 22-25, 2011 Pacific Grove, United States Phacilitate 7th Annual Cell & Gene Therapy Forum 2011 January 24-26, 2011 Washington, D.C., United States Phacilitate 9th Annual North American Vaccine Forum January 24-26, 2011 Washington, D.C., United States AACR-ACS Joint Meeting on Chemistry in Cancer Research: The Biological Chemistry of Inflammation as a Cause of Cancer January 30-February 2, 2011 San Diego, United States Keystone Symposia: Dendritic Cells and the Initiation of Adaptive Immunity February 12-17, 2011 Santa Fe, United States Keystone Symposia: Genetics, Immunology and Repair in Multiple Sclerosis February 15-20, 2011 Taos, United States BMT Tandem Meetings (ASBMT/CIBMTR) February 17-21, 2011 Honolulu, Hawaii 18th Conference on Retroviruses and Opportunistic Infections (CROI 2011) February 27-March 2, 2011 Boston, United States The 6th International Conference on Oncolytic Viruses as Cancer Therapeutics March 16-19, 2011 Las Vegas, United States 2011 American Academy of Allergy, Asthma and Immunology (AAAAI) Annual Meeting March 18-22, 2011 San Francisco, United States Microbiota and Mucosal Immunology: The Interface in Health and Disease April 14-16, 2011 San Francisco, United States GTCbio 2nd International Conference on Cancer Immunotherapy & Immunomonitoring May 2-5, 2011 Budapest, Hungary American Society of Gene and Cell Therapy (ASGCT) 14th Annual Meeting May 18-21, 2011 Seattle, United States Gordon Research Conference: Viruses & Cells May 29-June 3, 2011 Lucca (Barga), Italy Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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