TOP STORY New Class of ‘Dancing’ Dendritic Cells Derived from Blood Monocytes Dendritic cells are still notoriously difficult to study in humans. Samples, which come primarily from bone marrow or lymphoid tissue, are simply too difficult to obtain. But new research has shown scientists a way to study “authentic” dendritic cells from mouse monocytes, which are abundant in the blood, a much more accessible source in humans. [Press release from The Rockefeller University discussing online prepublication in Cell]
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CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal) Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell Areas Dendritic cells (DCs), critical antigen-presenting cells for immune control, normally derive from bone marrow precursors distinct from monocytes. It is not yet established if the large reservoir of monocytes can develop into cells with critical features of DCs in vivo . Researchers now show that fully differentiated monocyte-derived DCs develop in mice and DC-SIGN/CD209a marks the cells. [Cell] The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation To define host genetic effects on the outcome of a chronic viral infection, researchers performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and analyzed the effects of individual amino acids within the classical HLA proteins. [Science] A Role for IL-27p28 as an Antagonist of gp130-Mediated Signaling Here, researchers show that IL-27 subunits p28 (IL-27p28), independently of EBI3, antagonized cytokine signaling through gp130 and IL-6-mediated production of IL-17 and IL-10. [Nat Immunol] Immunosuppressive CD14(+)HLA-DR(low/neg) Monocytes in B Cell Non-Hodgkin’s Lymphoma Researchers examined the immunophenotype of 40 non-Hodgkin’s lymphoma patients and 27 age-matched controls to better understand systemic immune suppression. [Blood] Ubiquitination Regulates MHC Class II-Peptide Complex Retention and Degradation in Dendritic Cells Researchers now show that ubiquitination of MHC class II-peptide complex (pMHC-II) by the E3 ubiquitin ligase membrane-associated RING-CH 1 regulates surface expression, intracellular distribution, and survival of pMHC-II in dendritic cells. [Proc Natl Acad Sci USA] Role of Antigen Persistence and Dose for CD4+ T Cell Exhaustion and Recovery Here, researchers dissected the behavior of primed CD4+ T cells exposed to persistent antigen using an inducible transgenic mouse system that allowed them to control antigen presentation as the only experimental variable, independent of the persistent inflammation and disease progression that complicate infectious models. [Proc Natl Acad Sci USA] Increased B7-H1 Expression on Dendritic Cells Correlates with Programmed Death 1 Expression on T Cells in Simian Immunodeficiency Virus-Infected Macaques and May Contribute to T Cell Dysfunction and Disease Progression Using the rhesus macaque model, researchers show B7-H1 (programmed death [PD]-L1) is expressed on lymphoid and mucosal dendritic cells (DCs) (both myeloid DCs and plasmacytoid DCs), and its expression significantly increases after simian immunodeficiency virus infection. [J Immunol] Mesenchymal Stem Cells Contribute to the Abnormal Bone Marrow Microenvironment in Patients with Chronic Idiopathic Neutropenia by Overproduction of Transforming Growth Factor-Beta1 In this study, researchers investigated the possible involvement of bone marrow (BM) mesenchymal stem cells (MSCs) in the pathophysiology of chronic idiopathic neutropenia by assessing the frequency and function of BM MSCs in terms of the proliferative/clonogenic characteristics, the differentiation capacity, the potential to produce pro-inflammatory cytokines and the ability to suppress T cell proliferation. [Stem Cells Dev] Indoleamine 2,3-Dioxygenase and Regulatory Dendritic Cells Contribute to the Allograft Protection Induced by Infusion of Donor-Specific Splenic Stromal Cells Here, researchers have used both murine skin and cardiac allograft transplantation models to explore whether in vivo alloresponses can be regulated by infusion with donor-derived splenic stromal cells (SSCs) and to investigate the possible mechanisms by which SSCs exert regulatory effects to prevent allograft rejection. [Cell Mol Immunol]
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EVENTS (Listed by Date) 39th Autumn Immunology Conference November 19-22, 2010 Chicago, United States American Association for Cancer Research (AACR) Tumor Immunology – Basic and Clinical Advances November 30-December 3, 2010 Miami, United States Cell Symposia: Influenza – Translating Basic Insights December 2-4, 2010 Washington, D.C., United States 5th Annual Stem Cell Meeting on the Mesa December 7, 2010 La Jolla, United States The 50th Midwinter Conference of Immunologists at Asilomar January 22-25, 2011 Pacific Grove, United States Phacilitate 7th Annual Cell & Gene Therapy Forum 2011 January 24-26, 2011 Washington, D.C., United States Phacilitate 9th Annual North American Vaccine Forum January 24-26, 2011 Washington, D.C., United States AACR-ACS Joint Meeting on Chemistry in Cancer Research: The Biological Chemistry of Inflammation as a Cause of Cancer January 30-February 2, 2011 San Diego, United States Keystone Symposia: Dendritic Cells and the Initiation of Adaptive Immunity February 12-17, 2011 Santa Fe, United States Keystone Symposia: Genetics, Immunology and Repair in Multiple Sclerosis February 15-20, 2011 Taos, United States Lorne Infection and Immunity Conference 2011 February 16-18, 2011 Lorne, Australia 18th Conference on Retroviruses and Opportunistic Infections (CROI 2011) February 27-March 2, 2011 Boston, United States The 6th International Conference on Oncolytic Viruses as Cancer Therapeutics March 16-19, 2011 Las Vegas, United States 2011 American Academy of Allergy, Asthma and Immunology (AAAAI) Annual Meeting March 18-22, 2011 San Francisco, United States Microbiota and Mucosal Immunology: The Interface in Health and Disease April 14-16, 2011 San Francisco, United States GTCbio 2nd International Conference on Cancer Immunotherapy & Immunomonitoring May 2-5, 2011 Budapest, Hungary American Society of Gene and Cell Therapy (ASGCT) 14th Annual Meeting May 18-21, 2011 Seattle, United States Gordon Research Conference: Viruses & Cells May 29-June 3, 2011 Lucca (Barga), Italy Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
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