Immune Regulation News Volume 2.47 | Dec 10 2010

    By
    Justin.choi
    -
    0
    109

    Immune Regulation News 2.47, December 10, 2010.
    In this issue: Science News  |  Current Publications  |  Industry News  |  Policy News  |  EventsSubscribe  |  Unsubscribe

    TOP STORY

    Vanderbilt Study Explains Disproportionate Illness and Deaths Among Young Adults During H1N1 Pandemic Flu  ShareThis
    The study’s findings suggest people are made critically ill, or even killed, by their own immune response. [Press release from Vanderbilt University Medical Center discussing online prepublication in Nature Medicine]

    NegSelRosetteSep_645x110_v01

    SPECIAL FEATURE

    Interested in recruiting talented individuals? Post your career opportunities in Immune Regulation News at no cost. Contact us at info@connexoncreative.com

    Twitter Follow us on Twitter! @Immune_News

    SCIENCE NEWS

    Some Stem Cells Protect TB Bacteria: Study
    Certain stem cells protect tuberculosis (TB) bacteria from being destroyed, which explains why TB can lie dormant for years or even decades in the human body, researchers said. [Press release from Reuters discussing online prepublication in the Proceedings of the National Academy of Sciences]

    There’s a New ‘Officer’ in the Infection Control Army
    Scientists have identified a previously unrecognized step in the activation of infection-fighting white blood cells, the main immunity troops in the body’s war on bacteria, viruses and foreign proteins. [Press release from Johns Hopkins Medicine discussing online prepublication in Molecular Cell]

    Aggressive Blood Cancers: Adoptive Transfer of Regulatory T Cell-Depleted Donor T Helper Type 1 and T Helper Type 2 Cells Safely Accelerates Alloengraftment after Low-Intensity Chemotherapy
    Researchers conducted a clinical trial to evaluate the effectiveness of infusing cultured donor immune cells known as “T-rapa” cells after stem cell transplantation into patients being treated for blood-related cancers. [Press release from ScienceDaily discussing research presented at the 52nd Annual Meeting of the American Society of Hematology]

    MultipleMyeloma_645x110_V02

    CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

    Severe Pandemic 2009 H1N1 Influenza Disease due to Pathogenic Immune Complexes
    The observations provide a previously unknown biological mechanism for the unusual age distribution of severe cases during influenza pandemics. [Nat Med]

    The Enhancer HS2 Critically Regulates GATA-3-Mediated Il4 Transcription in T Helper Type 2 Cells
    Researchers identify the DNase I-hypersensitive site 2 (HS2) element located in the second intron of the interleukin 4 locus (Il4) as a critical enhancer strictly controlled by GATA-3 binding. [Nat Immunol]

    Control of the Differentiation of Regulatory T Cells and T Helper Type 17 Cells by the DNA-Binding Inhibitor Id3
    Scientists show that deletion of the DNA-binding inhibitor Id3 resulted in the defective generation of Foxp3+ regulatory T cells. [Nat Immunol]

    Plasmacytoid Dendritic Cell Ablation Impacts Early Interferon Responses and Antiviral NK and CD8+ T Cell Accrual
    Investigators conclude that plasmacytoid dendritic cells mediate early antiviral type I interferon responses and influence the accrual of virus-specific natural killer (NK) or CD8+ T cells in a virus-dependent manner. [Immunity]

    Antiphospholipid Antibodies Promote Leukocyte-Endothelial Cell Adhesion and Thrombosis in Mice by Antagonizing eNOS via Beta-2GPI and apoER2
    In antiphospholipid syndrome, antiphospholipid antibodies binding to beta-2 glycoprotein I (beta-2GPI) induce endothelial cell-leukocyte adhesion and thrombus formation via unknown mechanisms. Here, scientists show that in mice both of these processes are caused by the inhibition of the endothelial isoform of NOS. [J Clin Invest]

    Mycobacterium tuberculosis Evades Host Immunity by Recruiting Mesenchymal Stem Cells
    Scientists demonstrate that Mycobacterium tuberculosis suppresses T-lymphocyte responses by recruiting mesenchymal stem cells to the site of infection. [Proc Natl Acad Sci U S A]
     
    Genetic Immunization in the Lung Induces Potent Local and Systemic Immune Responses
    Genetic immunization in the lung offers a powerful platform approach to generating protective immune responses against respiratory pathogens. [Proc Natl Acad Sci U S A]

    Tumor Ablation by Gene-Modified T Cells in the Absence of Autoimmunity
    To determine whether gene-modified T cells could induce antitumor effects without associated autoimmune pathology, scientists assessed the ability of T cells expressing an anti-Her-2 chimeric receptor to eradicate tumor in Her-2 transgenic mice that express human Her-2 as a self-antigen in brain and mammary tissues. [Cancer Res]

    Potent Antirheumatic Activity of a New DNA Vaccine Targeted to B7-2/CD28 Costimulatory Signaling Pathway in Autoimmune Arthritis
    Scientists show a single intramuscular injection of their novel targeted DNA vaccine encoding Pseudomonas exotoxin A and costimulatory molecule B7-2 without autoantigens in a collagen-induced arthritis model simultaneously increased CD4+CD25+ regulatory T and CD8+CD28-suppressor T cells and selectively decreased autoreactive CD4+CD28+ T helper type 1 cells. [Hum Gene Ther]

    CD8+ T Cell Activation Predominate Early Immune Responses to Hypercholesterolemia in Apoe-/- Mice
    Researchers assessed immune responses to hypercholesterolemia induced by feeding Apoe-/- mice a high-fat diet for 4 or 8 weeks. [BMC Immunol]


    INDUSTRY NEWS

    GlaxoSmithKline and Human Genome Sciences Announce FDA Extension of Benlysta® PDUFA Target Date to 10th March 2011
    GlaxoSmithKline PLC and Human Genome Sciences, Inc. announced that the U.S. Food and Drug Administration (FDA) has extended the Prescription Drug User Fee Act target date for its priority review of the Biologics License Application for Benlysta® as a potential treatment for systemic lupus erythematosus from 9th December 2010 to 10th March 2011. [GlaxoSmithKline PLC Press Release]

    Biocon May Start Therapeutic Cancer Vaccine Trials Next Year
    Biocon Limited, in collaboration with a US-based research company, is working on creating a “therapeutic vaccine” that will help the body activate the immune system to fight cancer on its own. [Biocon Ltd. Press Release]

    SuppreMol Receives Public Research Funding to Advance its Lead Project SM101 into SLE as Further Indication
    SuppreMol GmbH announced it has been awarded research funding by the German Federal Ministry of Education and Research. [SuppreMol GmbH Press Release]

    Molecular Diagnostics Platform Will Enable Better Monitoring of Immune System in Human Disease
    Sequenta, Inc., a molecular diagnostics platform company focused on immune system profiling, announced that the company has raised $13 million in funding. [Sequenta, Inc. Press Release]

    Accentia Biopharmaceuticals Announces Strategic Agreement with Baxter
    Accentia Biopharmaceuticals, Inc. announced a strategic agreement with Baxter Healthcare Corporation to provide Accentia with the exclusive, worldwide right to purchase Baxter’s cyclophosphamide, which is marketed under the brand name Cytoxan®, for the treatment of designated autoimmune diseases including multiple sclerosis. [Accentia Biopharmaceuticals, Inc. Press Release]


    POLICY NEWS

    National Institutes of Health (United States)

    Food and Drug Administration (United States)

    Center for Biologics Evaluation and Research (United States)

    European Medicines Agency (European Union)

    Medicines and Healthcare Products Regulatory Agency (United Kingdom)

    Therapeutic Goods Administration (Australia)


    EVENTS (Listed by Date)

    The 50th Midwinter Conference of Immunologists at Asilomar
    January 22-25, 2011
    Pacific Grove, United States

    Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
    January 24-26, 2011
    Washington, D.C., United States

    Phacilitate 9th Annual North American Vaccine Forum
    January 24-26, 2011
    Washington, D.C., United States

    AACR-ACS Joint Meeting on Chemistry in Cancer Research: The Biological Chemistry of Inflammation as a Cause of Cancer
    January 30-February 2, 2011
    San Diego, United States

    Keystone Symposia: Dendritic Cells and the Initiation of Adaptive Immunity
    February 12-17, 2011
    Santa Fe, United States

    Keystone Symposia: Genetics, Immunology and Repair in Multiple Sclerosis
    February 15-20, 2011
    Taos, United States

    Lorne Infection and Immunity Conference 2011
    February 16-18, 2011
    Lorne, Australia

    18th Conference on Retroviruses and Opportunistic Infections (CROI 2011)
    February 27-March 2, 2011
    Boston, United States

    Cell Culture World Congress 2011 – Optimising Cell Culture Development for Biopharmaceutical, Bioprocessing and Manufacture
    February 28-March 2, 2011
    Munich, Germany

    PITTCON Conference & Expo 2011
    March 13-18, 2011
    Atlanta, United States

    The 6th International Conference on Oncolytic Viruses as Cancer Therapeutics
    March 16-19, 2011
    Las Vegas, United States

    2011 American Academy of Allergy, Asthma and Immunology (AAAAI) Annual Meeting
    March 18-22, 2011
    San Francisco, United States

    Microbiota and Mucosal Immunology: The Interface in Health and Disease
    April 14-16, 2011
    San Francisco, United States

    GTCbio 2nd International Conference on Cancer Immunotherapy & Immunomonitoring
    May 2-5, 2011
    Budapest, Hungary

    World Stem Cells & Regenerative Medicine Congress 2011
    May 9-11, 2011
    London, United Kingdom

    American Society of Gene and Cell Therapy (ASGCT) 14th Annual Meeting
    May 18-22, 2011
    Seattle, United States

    Gordon Research Conference: Viruses & Cells
    May 29-June 3, 2011
    Lucca (Barga), Italy

    DNA Vaccines 2011
    July 12-14, 2011
    San Diego, United States

    Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.

    JOB OPPORTUNITIES

    Lab Technologist – Human Embryonic and Induced Pluripotent Stem Cells (STEMCELL Technologies)

    Lab Technologist – Tissue Culture (STEMCELL Technologies)

    Recruit Top Talent
    Reach more than 11,000 potential candidates by posting your organization’s career opportunities with Cell Therapy News at no cost.

    Visit  here to post your career opportunities.


    Have we missed an important article or publication in Immune Regulation News? Click here to submit!



    Comments or Suggestions? Email info@connexoncreative.com with your feedback.


    Learn more about Immune Regulation News: Archives  |  Events  |  Subscribe  |  Contact Us