CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)
CD169-Positive Macrophages Dominate Antitumor Immunity by Crosspresenting Dead Cell-Associated Antigens
The major source of tumor antigens is dead tumor cells, but little is known about how antigen-presenting cells in draining lymph nodes acquire and crosspresent these antigens. Here, researchers show that CD169+ macrophages phagocytose dead tumor cells transported via lymphatic flow and subsequently crosspresent tumor antigens to CD8+ T cells. [Immunity]
Human Blood CXCR5+CD4+ T Cells Are Counterparts of T Follicular Cells and Contain Specific Subsets that Differentially Support Antibody Secretion
Here, researchers show that human blood CXCR5+CD4+ T cells share functional properties with T follicular helper cells and appear to represent their circulating memory compartment. [Immunity]
A Highly Tilted Binding Mode by a Self-Reactive T Cell Receptor Results in Altered Engagement of Peptide and MHC
Self-reactive T cells that escape elimination in the thymus can cause autoimmune pathology, and it is therefore important to understand the structural mechanisms of self-antigen recognition. Researchers report the crystal structure of a T cell receptor from a patient with relapsing-remitting multiple sclerosis that engages its self-peptide-major histocompatibility complex ligand in an unusual manner. [J Exp Med]
Acquisition and Presentation of Follicular Dendritic Cell-Bound Antigen by Lymph Node-Resident Dendritic Cells
In this study, researchers show that follicular dendritic cell (DC)-retained antigens are continually sampled by lymph node-resident DCs for presentation to CD8 T cells. [J Exp Med]
IL-27 Promotes T Cell-Dependent Colitis through Multiple Mechanisms
Because the role of Interleukin-27 (IL-27) in human and experimental mouse colitis is controversial, researchers studied the consequences of Il27ra deletion in the mouse T cell transfer model of colitis and unexpectedly discovered a proinflammatory role of IL-27. [J Exp Med]
CD137 Stimulation Enhances the Anti-Lymphoma Activity of Anti-CD20 Antibodies
In a syngeneic murine lymphoma model and in a xenotransplanted human lymphoma model, sequential administration of anti-CD20 monoclonal antibody (mAb) followed by anti-CD137 mAb has potent anti-lymphoma activity in vivo. These results support a novel, sequential antibody approach against B cell malignancies by targeting first the tumor and then the host immune system. [Blood]
T Helper Cell Type 2 (Th2) Memory T Cell-Potentiating Cytokine IL-25 Has the Potential to Promote Angiogenesis in Asthma
Researchers hypothesized that IL-25 stimulates local angiogenesis in the asthmatic bronchial mucosa. Immunoreactive IL-25+, IL-25R+, and CD31+ (endothelial) cells in sections of bronchial biopsies from asthmatics and controls were detected by immunohistochemistry. [Proc Natl Acad Sci USA]
T Cell Receptor Ligation Induces Distinct Signaling Pathways in Naïve vs. Antigen-Experienced T Cells
Naïve T lymphocytes display weaker and slower responses than antigen-experienced cells for reasons that are not well understood. Here, researchers show that T-cell receptor stimulation induces distinct ERK and p38 phosphorylation patterns in naïve and antigen-experienced human T cells, and that these contribute to the differential responses shown by these cells. [Proc Natl Acad Sci USA]
Pattern On the Antinuclear Antibody-HEp-2 Test Is a Critical Parameter for Discriminating Antinuclear Antibody-Positive Healthy Individuals and Patients with Autoimmune Rheumatic Diseases
The purpose of the study was to identify features of antinuclear antibody (ANA)-HEp-2 test results that discriminate ANA-positive healthy individuals and patients with autoimmune rheumatic diseases. [Arthritis Rheum]
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INDUSTRY NEWS
SYMPHOGEN Raises 100 Million Euros in Private Equity Round
Symphogen, a private biopharmaceutical company developing superior antibody therapeutics (monoclonal, monoclonal mixtures and polyclonal) to treat cancer, infectious and autoimmune diseases, announced that it closed a 100 million euro placement of Preferred Stock to a group of investors. [Symphogen Press Release]
VBL Therapeutics to Present at 29th Annual J.P. Morgan Healthcare Conference
VBL Therapeutics, a clinical-stage biotechnology company committed to the development of novel treatments for immune-inflammatory diseases and cancer, announced that Dror Harats, M.D., chief executive officer, will present at the 29th Annual J.P. Morgan Healthcare Conference. [VBL Therapeutics Press Release]
Particle Sciences Develops Wax Nanoparticles that Enhance Immune Response to Antigens
Particle Sciences Inc. (PSI), a leading pharmaceutical CRO has formulated a series of wax nanoparticles that, when coupled with an antigen, enhanced its immunogenicity, increasing both systemic and the mucosal immune response. [Particle Sciences Inc. Press Release]
Amgen and Xencor Enter Option Deal to Co-Develop Xencor’s Novel Antibody for Autoimmune Diseases
Amgen and Xencor, Inc. announced that they will collaborate to develop XmAb(R)5871, an Fc- engineered monoclonal antibody dually targeting CD19 and CD32b. [Amgen Press Release]
Spirogen Ltd. Announces a Research Collaboration and License Agreement With Genentech for the Discovery and Development of Antibody Drug Conjugates
Spirogen Ltd. a leading oncology-focused company developing DNA sequence targeted agents, announced a multi-year research collaboration and license agreement with Genentech, a member of the Roche Group. [PR Newswire]
SERVIER Announces Joint Development and Commercialization with XOMA on Novel Therapeutics for Orphan Disease
Servier and XOMA Ltd., a leader in the discovery and development of therapeutic antibodies, announced the signing of an agreement to jointly develop and commercialize XOMA 052, XOMA’s anti-inflammatory drug candidate, in multiple indications. [Servier Press Release]
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