CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)
A Thymus Candidate in Lampreys Here researchers identify discrete thymus-like lympho-epithelial structures, termed thymoids, in the tips of the gill filaments and the neighbouring secondary lamellae (both within the gill basket) of lamprey larvae. [Nature] Interferon-Gamma Links Ultraviolet Radiation to Melanomagenesis in Mice Here researchers introduce a mouse model permitting fluorescence-aided melanocyte imaging and isolation following in vivo UV irradiation. Researchers use expression profiling to show that activated neonatal skin melanocytes isolated following a melanomagenic UVB dose bear a distinct, persistent interferon response signature, including genes associated with immunoevasion. [Nature] Tumor Regression in Patients With Metastatic Synovial Cell Sarcoma and Melanoma Using Genetically Engineered Lymphocytes Reactive With NY-ESO-1 The current trial was carried out to evaluate the ability of adoptively transferred autologous T cells transduced with a T-cell receptor directed against NY-ESO-1 to mediate tumor regression in patients with metastatic melanoma and synovial cell sarcoma. [J Clin Oncol] Activation-Induced Cytidine Deaminase Induces Reproducible DNA Breaks at Many Non-Ig Loci in Activated B Cells Using a nonbiased genome-wide approach, researchers have identified hundreds of reproducible, activation-induced cytidine deaminase (AID)-dependent double-strand DNA breaks in mouse splenic B cells shortly after induction of antibody class switch recombination in culture. [Mol Cell] B Cell Depletion Reactivates B Lymphopoiesis in the BM and Rejuvenates the B Lineage in Aging Researchers show here that age-related changes in the B lineage are mediated by the accumulating long-lived B cells. [Blood] The Dual Impact of HIV-1 Infection and Aging on Naïve CD4+ T-Cells: Additive and Distinct Patterns of Impairment As naïve T-cells are critically important in responses to neoantigens, researchers first analyzed two subsets (CD45RA+CD31+ and CD45RA+CD31-) within the naïve CD4+ T-cell compartment in young (20-32 years old) and older (39-58 years old), antiretroviral therapy-naïve, HIV-1 seropositive individuals within 1-3 years of infection and in age-matched seronegative controls. [PLoS ONE] Acquisition of HIV-1 Resistance in T Lymphocytes Using an ACA-Specific E. coli mRNA Interferase Here researchers take a genetic approach to suppress HIV-1 replication based on Tat-dependent production of MazF, an ACA-specific endoribonuclease (mRNA interferase) from Escherichia coli (E. coli). [Hum Gene Ther] Potency of Mature CD40L RNA Electroporated Dendritic Cells Correlates With IL-12 Secretion by Tracking Multifunctional CD8+/CD28+ Cytotoxic T-cell Responses In vitro results presented herein reveal a correlation between the priming of CD28+ antigen-reactive effector memory cytotoxic T lymphocytes displaying 3 or 4 simultaneous effector functions and the quantity of IL-12 produced by postmaturation electroporation-CD40L dendritic cells. [J Immunother] Co-Delivery of PSA and PSMA DNA Vaccines With Electroporation Induces Potent Immune Responses Scientists sought to test the hypothesis that a broader collection of antigens would improve the breadth and effectiveness of a prostate cancer (PCa) immune therapy approach. They developed highly optimized DNA vaccines encoding prostate-specific antigen (PSA) and prostate-specific membrane antigen (PSMA) as a dual antigen approach to immune therapy of PCa. [Hum Vaccin] Manipulating the Bioenergetics of Alloreactive T Cells Causes Their Selective Apoptosis and Arrests Graft-Versus-Host Disease Investigators found that bone marrow (BM) cells proliferating after BM transplantation increased aerobic glycolysis but not oxidative phosphorylation (OXPHOS), whereas T cells proliferating in response to alloantigens during graft-versus-host disease increased both aerobic glycolysis and OXPHOS. [Sci Trans Med]
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