Scientists Use Genetically Altered Virus to Get Tumors to Tattle on Themselves
Scientists have used a genetically re-engineered herpes virus that selectively hunts down and infects cancerous tumors and then delivers genetic material that prompts cancers to secrete a biomarker and reveal their presence. [Press release from the Cincinnati Children’s Hospital Medical Center discussing online prepublication in PLoS ONE]
Scripps Research Scientists Show How Shifts in Temperature Prime Immune Response
Researchers have found a temperature-sensing protein within immune cells that, when tripped, allows calcium to pour in and activate an immune response. [Press release from The Scripps Research Institute discussing online prepublication Nature Chemical Biology]
Immune System Malfunction May Trigger Inflammatory Bowel Disease
Researchers have identified a previously unknown sensor regulating the composition of certain intestinal bacterial microflora. They also found the absence of this regulating sensor results in a dramatic alteration of the microbial environment of the intestines – increasing the risk of developing inflammatory bowel disease. [Press release from Yale University discussing online prepublication in Cell]
Important Step in Breakdown of HIV Proteins is Critical to Immune System Recognition, Destruction of Infected Cells
Researchers have found that – as HIV proteins are broken down within cells, a process that should lead to labeling infected cell for destruction by CD8 T cells – there is a great variability in the stability of resulting protein segments, variations that could significantly change how well cells are recognized by the immune system. [Press release from the Ragon Institute of MGH, MIT and Harvard discussing online prepublication in The Journal of Clinical Investigation]
Inovio Pharmaceuticals Reports Long-Term Immune Responses from Therapeutic Cervical Dysplasia and Cancer DNA Vaccine
Strong, persistent T cell responses in 91% of assessed patients in the Phase I study further validate vaccine’s potential utility in current Phase II study. [Press release from Inovio Pharmaceuticals discussing data presented at the 15th Annual Conference on Women’s Health Care Issues]
Non-Human Primate Studies Reveal Promising Vaccine Approach for HIV
Research conducted has developed a vaccine candidate in non-human primates that may eventually lead to a vaccine against Human Immunodeficiency Virus (HIV). [Press release from Oregon Health & Science University discussing online prepublication in Nature]