| TOP STORY | Non-Canonical Inflammasome Activation Targets Caspase-11 Here researchers show, with C57BL/6 Casp11 gene-targeted mice, that caspase-11 (also known as caspase-4) is critical for caspase-1 activation and interleukin-1β production in macrophages infected with Escherichia coli, Citrobacter rodentium or Vibrio cholerae. [Nature] Abstract |
| PUBLICATIONS (Ranked by Impact Factor of the Journal) | The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine The findings reveal that RegIIIγ is a fundamental immune mechanism that promotes host-bacterial mutualism by regulating the spatial relationships between microbiota and host. [Science] Abstract | Press Release Intestinal Microbiota Promote Enteric Virus Replication and Systemic Pathogenesis Researchers found that poliovirus binds lipopolysaccharide, and exposure of poliovirus to bacteria enhanced host cell association and infection. [Science] Abstract | Press Release Transcription Factor c-Maf Mediates the TGF-β-Dependent Suppression of IL-22 Production in TH17 Cells Here researchers identify the transcription factor c-Maf, which is induced by transforming growth factor-β (TGF-β), as a downstream repressor of Il22. [Nat Immunol] Abstract Differential Expression of Ly6C and T-bet Distinguish Effector and Memory T Helper 1 CD4+ Cell Properties During Viral Infection This study provides a framework for memory CD4+ T cell development after acute viral infection. [Immunity] Abstract Functional and Epigenetic Studies Reveal Multistep Differentiation and Plasticity of In Vitro-Generated and In Vivo-Derived Follicular T Helper Cells Investigators describe the in vitro differentiation of functionally competent follicular T helper (Tfh)-like cells that expressed interleukin-21, Tfh cell markers, and Bcl6 and rescued germinal center formation in SLAM-associated protein-deficient hosts better than other T helper cells. [Immunity] Abstract Notch2 Receptor Signaling Controls Functional Differentiation of Dendritic Cells in the Spleen and Intestine Researchers report that dendritic cell (DC)-specific deletion of the Notch2 receptor caused a reduction of DC populations in the spleen. [Immunity] Abstract Opposing Signals from the Bcl6 Transcription Factor and the Interleukin-2 Receptor Generate T Helper 1 Central and Effector Memory Cells Researchers tracked endogenous Listeria monocytogenes-specific CD4+ T cells to determine how these memory cells are formed. [Immunity] Abstract Langerhans Cells Are Precommitted to Immune Tolerance Induction Here, researchers tested whether epidermal Langerhans cells can support immunogenic responses in vivo in the absence of antigen presentation by other dendritic cell subsets. [Proc Natl Acad Sci USA] Abstract | Press Release Epithelial Nuclear Factor-κB Signaling Promotes Lung Carcinogenesis via Recruitment of Regulatory T Lymphocytes To investigate whether nuclear factor-κB provides an interface between persistent lung inflammation and carcinogenesis, researchers utilized tetracycline-inducible transgenic mice expressing constitutively active IκB kinase β in airway epithelium. [Oncogene] Abstract Depleting Regulatory T Cells with Arginine-Rich, Cell-Penetrating, Peptide-Conjugated Morpholino Oligomer Targeting FOXP3 Inhibits Regulatory T-Cell Function Investigators hypothesized that targeting FOXP3 expression with a novel arginine-rich, cell-penetrating, peptide-conjugated phosphorodiamidate morpholino based antisense would eliminate CD4+CD25+ regulatory T cells and enhance the induction of effector T-cell responses. [Cancer Gene Ther] Abstract |
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