| PUBLICATIONS (Ranked by Impact Factor of the Journal) | Regulatory T-Cell Responses to Low-Dose Interleukin-2 in HCV-Induced Vasculitis Investigators reasoned that interleukin-2, a cytokine that promotes regulatory T cell survival and function, could be beneficial for patients with vasculitis that is resistant to hepatitis C virus (HCV) therapy. [N Engl J Med] Abstract Response to Self Antigen Imprints Regulatory Memory in Tissues Here researchers show that upon expression of self antigen in a peripheral tissue, thymus-derived regulatory T cells become activated, proliferate and differentiate into more potent suppressors, which mediate resolution of organ-specific autoimmunity in mice. [Nature] Abstract | Press Release Combined Genetic Inactivation of ß2-Microglobulin and CD58 Reveals Frequent Escape from Immune Recognition in Diffuse Large B Cell Lymphoma Scientists report that diffuse large B cell lymphoma commonly fails to express cell-surface molecules necessary for the recognition of tumor cells by immune-effector cells. [Cancer Cell] Abstract Identification of Bcl-6-Dependent Follicular Helper NKT Cells that Provide Cognate Help for B Cell Responses Here researchers show that in vivo, natural killer T (NKT) cells engaged in stable and prolonged cognate interactions with B cells and induced the formation of early germinal centers. [Nat Immunol] Abstract Invariant Natural Killer T Cells Direct B Cell Responses to Cognate Lipid Antigen in an IL-21-Dependent Manner Here scientists found that cognate invariant natural killer T cell (iNKT cell) help resulted in a B cell differentiation program characterized by extrafollicular plasmablasts, germinal-center formation, affinity maturation and a robust primary immunoglobulin G antibody response that was uniquely dependent on iNKT cell–derived interleukin 21 (IL-21). [Nat Immunol] Abstract Priming Microenvironments Dictate Cytokine Requirements for T Helper 17 Cell Lineage Commitment Here, investigators have discovered that the cytokine requirements for T helper 17 cell polarization depend on the site of priming. [Immunity] Abstract The NF-κB1 Transcription Factor Prevents the Intrathymic Development of CD8 T Cells with Memory Properties Here, scientists show that mice lacking NF-κB1 develop a unique population of conventional CD8 single-positive thymocytes with memory T cell-like properties that populate peripheral immune organs. [EMBO J] Abstract Antitumor Activity from Antigen-Specific CD8 T Cells Generated In Vivo from Genetically Engineered Human Hematopoietic Stem Cells Here, researchers present the generation of functional tumor-specific human T cells in vivo from genetically modified human hematopoietic stem cells using a human/mouse chimera model. [Proc Natl Acad Sci USA] Abstract Quantitative Differences in CD45 Expression Unmask Functions for CD45 in B-Cell Development, Tolerance, and Survival Although high expression of CD45 inhibits T-cell receptor signaling, researchers show that CD45 plays a purely positive regulatory role during B-cell receptor signaling. [Proc Natl Acad Sci USA] Abstract CCAAT/Enhancer Binding Protein-δ Expression by Dendritic Cells Regulates CNS Autoimmune Inflammatory Disease Researchers’ findings identify CCAAT enhancer binding protein-δ as an important dendritic cell transcription factor in CNS autoimmune inflammatory disease by virtue of its capacity to alter the T helper 17:regulatory T cell balance in an interleukin-10 dependent fashion. [J Neurosci] Abstract |
| INDUSTRY NEWS | Ablynx Reports Positive Phase I Data for ALX-0061 in Rheumatoid Arthritis Ablynx announced positive Phase I data from the single ascending dose part of the Phase I/II study with ALX-0061, the anti-IL-6R Nanobody, in patients with rheumatoid arthritis. [Ablynx NV] Press Release Horizon Pharma Announces U.S. Food and Drug Administration Acceptance of LODOTRA® New Drug Application for Review for the Treatment of Rheumatoid Arthritis Horizon Pharma, Inc. announced that the United States Food and Drug Administration has accepted for filing and review its New Drug Application for LODOTRA® for the treatment of rheumatoid arthritis in adults, and set a PDUFA date of July 26, 2012, based on the standard 10 month review. [Horizon Pharma, Inc.] Press Release Lloyd J. Old, M.D., Father of Modern Tumor Immunology, Dies at 78 of Prostate Cancer The Cancer Research Institute (CRI) announced that CRI founding scientific and medical director Lloyd J. Old, M.D., regarded as the “Father of Modern Tumor Immunology,” died at his home in New York City from prostate cancer. [Cancer Research Institute] Press Release |
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