| TOP STORY | IL-10 Elicits IFNγ-Dependent Tumor Immune Surveillance Researchers demonstrate that IL-10 induces several essential mechanisms for effective antitumor immune surveillance: infiltration and activation of intratumoral tumor-specific cytotoxic CD8+ T cells, expression of the Th1 cytokine interferon-γ (IFNγ) and granzymes in CD8+ T cells, and intratumoral antigen presentation molecules. [Cancer Cell] Abstract |
| PUBLICATIONS (Ranked by Impact Factor of the Journal) | Asymmetric B Cell Division in the Germinal Center Reaction Here, researchers show that germinal center B lymphocytes asymmetrically segregate the transcriptional regulator Bcl6, the receptor for interleukin-21, and the ancestral polarity protein atypical PKC to one side of the plane of division, generating unequal inheritance of fate-altering molecules by daughter cells. [Science] Abstract Therapeutic Blockade of PD-L1 and LAG-3 Rapidly Clears Established Blood-Stage Plasmodium Infection Here investigators show that infection of humans with Plasmodium falciparum resulted in higher expression of the inhibitory receptor PD-1 associated with T cell dysfunction. [Nat Immunol] Abstract Plasmacytoid Dendritic Cells Are Crucial for the Initiation of Inflammation and T Cell Immunity In Vivo Here researchers report a critical role for plasmacytoid dendritic cells (pDCs) in the regulation of inflammation and T cell immunity in vivo by using gene-targeted mice with a deficiency of Siglec-H and conditional ablation of pDCs. [Immunity] Abstract Th17 Cells Induce Ectopic Lymphoid Follicles in Central Nervous System Tissue Inflammation Here scientists showed that in experimental autoimmune encephalomyelitis, Th17 cells specifically induced ectopic lymphoid follicles in the central nervous system. [Immunity] Abstract The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells Here, researchers have shown that the aryl hydrocarbon receptor plays an essential role in RORγt+ innate lymphoid cell maintenance and function. [Immunity] Abstract Cytosolic RIG-I–Like Helicases Act as Negative Regulators of Sterile Inflammation in the CNS Results identify RIG-I–like helicases (RLHs) as negative regulators of TH1 and TH17 responses in the CNS, demonstrate a protective role of the RLH pathway for brain inflammation, and establish oligonucleotide ligands of RLHs as potential therapeutics for the treatment of multiple sclerosis. [Nat Neurosci] Abstract Antigen-Specific CD4 T-Cell Help Rescues Exhausted CD8 T Cells during Chronic Viral Infection Whether function can be restored in already exhausted CD8 T cells by providing CD4 T-cell help at a later time remains unexplored. In this study, researchers used a mouse model of chronic lymphocytic choriomeningitis virus infection to address this question. [Proc Natl Acad Sci USA] Abstract | Press Release Natural Killer Cell Activation Enhances Immune Pathology and Promotes Chronic Infection by Limiting CD8+ T-Cell Immunity Here investigators demonstrate that natural killer cells have a negative impact on the development of T-cell immunity by using the murine lymphocytic choriomeningitis virus. [Proc Natl Acad Sci USA] Abstract Polyfunctional Responses by Human T Cells Result from Sequential Release of Cytokines Here, scientists used serial, time-dependent, single-cell analysis of primary human T cells to resolve the temporal dynamics of cytokine secretion from individual cells after activation ex vivo. [Proc Natl Acad Sci USA] Abstract Modulation of Autoimmune Demyelination by Laquinimod via Induction of Brain-Derived Neurotrophic Factor Researchers investigated the effect of laquinimod in experimental autoimmune encephalomyelitis using a conditional brain-derived neurotrophic factor (BDNF) knockout strain lacking BDNF expression in myeloid cells and T cells. [Am J Pathol] Abstract | Press Release |
|
|
|