Immune Regulation News Volume 4.07 | Feb 24 2012

The Earliest Thymic T Cell Progenitors Sustain B Cell and Myeloid Lineage Potential
Here researchers provide functional and molecular evidence at the single-cell level that the earliest progenitors in the neonatal thymus had combined granulocyte-monocyte, T lymphocyte and B lymphocyte lineage potential but not megakaryocyte-erythroid lineage potential. [Nat Immunol] Abstract

Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity
SOCS3 (suppressor of cytokine signaling-3) is a major regulator of janus kinase (JAK) signaling and here researchers investigate the molecular basis of its mechanism of action. [Immunity] Abstract | Press Release

Intravital Imaging of Thymopoiesis Reveals Dynamic Lympho-Epithelial Interactions
Here, researchers describe transgenic zebrafish lines enabling the in vivo observation of thymopoiesis. [Immunity] Abstract | Press Release

An NLRP7-Containing Inflammasome Mediates Recognition of Microbial Lipopeptides in Human Macrophages
Here researchers describe identification and characterization of an NLRP7 inflammasome in human macrophages, which is induced in response to microbial acylated lipopeptides. [Immunity] Abstract

Tolerance to Apoptotic Cells Is Regulated by Indoleamine 2,3-Dioxygenase
Researchers demonstrate that pharmacologic inhibition of indoleamine 2,3-dioxygenase skewed the immune response to apoptotic cells, resulting in increased proinflammatory cytokine production and increased effector T-cell responses toward apoptotic cell-associated antigens. [Proc Natl Acad Sci USA]
Abstract | Press Release

CC Chemokine Receptor 4 Is Required for Experimental Autoimmune Encephalomyelitis by Regulating GM-CSF and IL-23 Production in Dendritic Cells
This study demonstrates that expression of CC chemokine receptor 4 by dendritic cells is required for experimental autoimmune encephalomyelitis induction. [Proc Natl Acad Sci USA] Abstract

Plasmacytoid Dendritic Cells Sequester High Prion Titres at Early Stages of Prion Infection
Whilst prions were detectable in B and T lymphocytes and in antigen-presenting cells like dendritic cells and macrophages, highest infectious titers were determined in two cell types that have previously not been associated with prion pathogenesis, plasmacytoid dendritic and natural killer cells. [PLoS Pathog] Abstract

Efficient Capture of Infected Neutrophils by Dendritic Cells in the Skin Inhibits the Early Anti-Leishmania Response
Researchers’ findings suggest that following their rapid uptake by neutrophils in the skin, Leishmania major exploits the immunosuppressive effects associated with the apoptotic cell clearance function of dendritic cells to inhibit the development of acquired resistance until the acute neutrophilic response is resolved. [PLoS Pathog] Abstract

Dissection of a Circulating and Intrahepatic CD4⁺Foxp3⁺ T-Cell Subpopulation in Chronic Hepatitis B Virus (HBV) Infection: A Highly Informative Strategy for Distinguishing Chronic HBV Infection States
Investigators found that circulating and intrahepatic CD4⁺CD45RA^–Foxp3^hi-activated regulatory T cells were selectively increased in patients with chronic active hepatitis B and acute-on-chronic liver failure but not in asymptomatic carriers. [J Infect Dis] Abstract

γδ T Cells Augment Rejection of Skin Grafts by Enhancing Cross-Priming of CD8 T Cells to Skin-Derived Antigen
In this study, researchers explored the role of γδ T cells in cutaneous immunity using a skin transplantation model. [J Invest Dermatol] Abstract

NW Bio Teams with the American Red Cross in DCVac® Program
Northwest Biotherapeutics (NW Bio) announced that it has entered into an agreement with the American Red Cross to provide blood collection services through which immune cells are obtained to make DCVax®-L treatments for brain cancer patients. [Northwest Biotherapeutics, Inc.] Press Release

UCB Announces Start of C-EARLY™ Study for Cimzia® (Certolizumab Pegol) in Rheumatoid Arthritis
UCB announced the start of C-EARLY™ – a phase III study that will evaluate the efficacy and safety of Cimzia^® in combination with methotrexate for inducing and sustaining clinical response in adults with early, progressive, active, moderate to severe rheumatoid arthritis, who have not previously been treated with disease-modifying antirheumatic drugs. [UCB S.A.] Press Release

AKC Canine Health Foundation Funds Project to Battle Lymphoma
Through the American Kennel Club (AKC) Canine Health Foundation’s support, Texas A&M University is continuing a ground-breaking lymphoma treatment therapy research project that uses laboratory expanded T-cells to help extend the lives of dogs that develop cancer. [American Kennel Club Canine Health Foundation, Inc.] Press Release

National Institute of Allergy and Infectious Diseases; Notice of Closed Meetings (FR Doc No: 2012-4099) [National Institutes of Health, United States]

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW European Group for Blood and Marrow Transplantation (EBMT) 2012
April 1-4, 2012
Geneva, Switzerland

NEW Canadian Society for Immunology (CSI) 2012 Meeting
June 15-18, 2012
St. John’s, Canada

Visit our events page to see a complete list of events in the immune regulation community.

Scientist – Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Research Technologist (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)  

Immunology Investigator (BloodCenter of Wisconsin)

Postdoctoral Fellow – Program in Children’s Regenerative Medicine (The University of Texas Medical School at Houston)

Postdoctoral Positions in Allergy and Immunology (University of Southern California)


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