Immune Regulation News Volume 4.13 | Apr 13 2012

Dynamic Transformations of Genome-Wide Epigenetic Marking and Transcriptional Control Establish T Cell Identity
To define molecular mechanisms controlling T cell developmental progression, researchers probed five stages spanning the commitment process using RNA-seq and ChIP-seq to track genome-wide shifts in transcription, cohorts of active transcription factor genes, histone modifications at diverse classes of cis-regulatory elements, and the binding repertoires of GATA-3 and PU.1, transcription factors with complementary roles in T cell development. [Cell] Abstract | Press Release

Ubc13 Maintains the Suppressive Function of Regulatory T Cells and Prevents Their Conversion into Effector-Like T Cells
Researchers found that T regulatory cell-specific ablation of Ubc13, a Lys63-specific ubiquitin-conjugating enzyme, caused aberrant T cell activation and autoimmunity. [Nat Immunol] Abstract

The Development and Fate of Follicular Helper T Cells Defined by an Interleukin-21 Reporter Mouse
The authors demonstrated that follicular helper T cells were not terminally differentiated but instead retained the flexibility to be recruited into other helper T cell subsets and nonlymphoid tissues. [Nat Immunol]
Abstract | Press Release

Transcriptional Profiling of Stroma from Inflamed and Resting Lymph Nodes Defines Immunological Hallmarks
Researchers used comparative transcriptomic analyses of mouse lymph node stromal cell subsets and demonstrated the expression of important immune mediators, growth factors and previously unknown structural components. [Nat Immunol] Abstract

Unbiased Identification of Target Antigens of CD8⁺ T Cells with Combinatorial Libraries Coding for Short Peptides
Researchers describe a technology for the unbiased identification of the antigenic peptides presented by major histocompatibility complex class I molecules. [Nat Med] Abstract

Notch Receptors and Smad3 Signaling Cooperate in the Induction of Interleukin-9-Producing T Cells
Scientists analyzed the costimulatory requirements for the induction of T helper 9 cells, and demonstrated that the Notch pathway cooperated with TGF-β signaling to induce interleukin-9. [Immunity] Abstract

12/15-Lipoxygenase Orchestrates the Clearance of Apoptotic Cells and Maintains Immunologic Tolerance
Scientists discovered a role for the enzyme 12/15-lipoxygenase as a central factor governing the sorting of apoptotic cells into differentially activated monocyte subpopulations. [Immunity] Abstract

The Dendritic Cell Receptor Clec9A Binds Damaged Cells via Exposed Actin Filaments
Researchers identified the Clec9A ligand as a filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins and propose that Clec9A provides targeted recruitment of the adaptive immune system during infection and can also be utilized to enhance immune responses generated by vaccines. [Immunity] Abstract

Redox Signal-Mediated Sensitization of Transient Receptor Potential Melastatin 2 (TRPM2) to Temperature Affects Macrophage Functions
Scientists suggest that TRPM2 sensitization plays important roles in macrophage functions. [Proc Natl Acad Sci USA] Abstract

Regulation of Monocyte Functional Heterogeneity by miR-146a and Relb
Considering the evidence that monocytes exist in at least two subsets committed to divergent functions, the authors investigated whether distinct factors regulate the balance between monocyte subset responses in vivo. [Cell Reports] Abstract

New $2.25 Million Infusion of NIH Funds for EpiVax’ Tregitope, Proposed “Paradigm-­Shifting” Treatment
EpiVax, Inc. was awarded a new National Institutes of Health (NIH) Small Business Innovation Research (SBIR) Phase II grant totaling $1.5 million in funding from the NIH’s National Institute of Diabetes and Digestive and Kidney Diseases to explore formulation, dose, route and delivery vehicle for Tregitope through the NIH SBIR program. [EpiVax, Inc.] Press Release

Shire Adds New Technology Platform and Phase II Product Candidate to its Regenerative Medicine Business
Shire plc announced that it has signed an agreement to acquire a substantial portion of the assets of Pervasis Therapeutics. [Shire plc] Press Release

£180 Million in Government Funding to Bridge the ‘Valley of Death’ for Medical Breakthroughs
A £180 million government scheme that will provide grant funding for innovative small and medium sized enterprises and academics to develop solutions to healthcare challenges will open for applications at the end of April. [Technology Strategy Board] Press Release

AnaptysBio Announces Strategic Antibody Discovery Partnership with Celegene Corporation
AnaptysBio, Inc. announced a strategic partnership with Celgene Corporation to develop novel antibodies against multiple therapeutic targets. [AnaptysBio] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW World Stem Cells & Regenerative Medicine Congress 2012
May 21-23, 2012
London, United Kingdom

NEW Cell Symposia – Human Immunity
August 19-21, 2012
Lisbon, Portugal

Visit our events page to see a complete list of events in the immune regulation community.

Scientist – Endothelial Cells (STEMCELL Technologies, Inc.)

Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.)

Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.)

Scientist – Hematology (STEMCELL Technologies, Inc.)

Scientist – hPSC (STEMCELL Technologies, Inc.)

Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)

Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)

Business Analyst – Product Management (STEMSOFT Software, Inc.)  

Postdoctoral Position in Molecular Immunology (Karmanos Cancer Institute)

Postdoctoral Fellowship – Central Nervous System and Immunological Disorders (UCB)


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