| TOP STORY | T Cells ‘Hunt’ Parasites Like Animal Predators Seek Prey A cross-disciplinary team has arrived at a surprising finding: T cells use a movement strategy to track down parasites that is similar to strategies that predators such as monkeys, sharks and blue-fin tuna use to hunt their prey. [Press release from the University of Pennsylvania discussing online prepublication in Nature] Press Release | Abstract |
| PUBLICATIONS (Ranked by impact factor of the journal) | Inhibitory Receptors Bind ANGPTLs and Support Blood Stem Cells and Leukaemia Development Researchers found that the immune-inhibitory receptor human leukocyte immunoglobulin-like receptor B2 and its mouse orthologue paired immunoglobulin-like receptor are receptors for several Angiopoietin-like proteins (ANGPTLs). [Nature] Abstract | Press Release Regulation of Type 2 Helper T Cell Development by CXCR5+ Dendritic Cells and Lymphotoxin-Expressing B Cells Researchers found that, after infection with an intestinal nematode, antigen-bearing dendritic cells and CD4+ T cells upregulated the chemokine receptor CXCR5 and localized together outside the T cell zone by a mechanism dependent on the chemokine CXCL13, B cells and lymphotoxin. [Nat Immunol] Abstract | Press Release TGF-β Signaling to T Cells Inhibits Autoimmunity during Lymphopenia-Driven Proliferation When researchers deleted the receptor for transforming growth factor-β (TGF-β) through the use of Cre driven by a promoter that is active much later in T cell development, adult mice in which most peripheral CD4+ or CD8+ T cells lacked the receptor for TGF-β showed no signs of autoimmunity. [Nat Immunol] Abstract Live Imaging of Tumor Initiation in Zebrafish Larvae Reveals a Trophic Role for Leukocyte-Derived Prostaglandin E2 Researchers took advantage of the translucency and genetic tractability of zebrafish larvae to investigate the involvement of inflammatory cells at cancer initiation, when transformed cells first arise in tissues. [Curr Biol] Abstract C/EBP Homologous Protein Contributes to Cytokine-Induced Pro-Inflammatory Responses and Apoptosis in β-Cells Data suggest that the C/EBP homologous protein (CHOP) has a dual role in promoting β-cell death: CHOP directly contributes to cytokine-induced β-cell apoptosis by promoting cytokine-induced mitochondrial pathways of apoptosis; and, by supporting the NF-κB activation and subsequent cytokine/chemokine expression, CHOP may contribute to apoptosis and the chemo attraction of mononuclear cells to the islets during insulitis. [Cell Death Differ] Abstract Loss of Mucosal CD103+ Dendritic Cells and IL-17+ and IL-22+ Lymphocytes Is Associated with Mucosal Damage in SIV Infection By investigating alterations in mucosal immunity during Simian immunodeficiency virus (SIV) infection, researchers found that damage to the colonic epithelial barrier was associated with loss of multiple lineages of interleukin (IL)-17-producing lymphocytes, cells that microarray analysis showed expressed genes important for enterocyte homeostasis, including IL-22. [Mucosal Immunol] Abstract NKT Cells Stimulated by Long Fatty Acyl Chain Sulfatides Significantly Reduces the Incidence of Type 1 Diabetes in Nonobese Diabetic Mice Data suggest that C24:0 stimulated type II NKT cells may regulate protection from T1D by activating DCs to secrete IL-10 and suppress the activation and expansion of type I iNKT cells and diabetogenic T cells. [PLoS One] Full Article Mincle Polarizes Human Monocyte and Neutrophil Responses to Candida albicans This study identified an unusual pattern of reciprocal expression of Mincle on peripheral blood monocytes or neutrophils isolated from the same donor. [Immunol Cell Biol] Abstract |
| JOB OPPORTUNITIES | Research Associate – Chemistry (STEMCELL Technologies, Inc.) Research Associate – Particle Chemistry (STEMCELL Technologies, Inc.) Research Technologist – Contract Assay Services (STEMCELL Technologies, Inc.) Research Technologist – Media Development (STEMCELL Technologies, Inc.) Scientist – Induced Pluripotent Stem Cells (STEMCELL Technologies, Inc.) Scientist – Epithelial Cell Research (STEMCELL Technologies, Inc.) Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.) Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.) Business Analyst – Product Management (STEMSOFT Software, Inc.) Postdoctoral Position – Protein Chemistry/Immuno-Receptor Biology (Genentech) Postdoctoral Position – Antigen Recognition by Human T Lymphocytes (Singapore Immunology Network) Faculty Openings – Molecular Microbiology and Immunology (University of Vienna) Postdoctoral Positions – Immunology (La Jolla Institute for Allergy and Immunology) Recruit Top Talent: Reach more than 50,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost. |
|
|
|