Immune Regulation News Volume 4.26 | Jul 13 2012

Ultraviolet Radiation Damages Self Noncoding RNA and Is Detected by Toll-Like Receptor 3
Researchers showed that RNA is released from keratinocytes after ultraviolet B exposure and that this stimulates production of the inflammatory cytokines tumor necrosis factor α and interleukin-6 from nonirradiated keratinocytes and peripheral blood mononuclear cells. [Nat Med] Abstract | Press Release

Robust Tumor Immunity to Melanoma Mediated by Interleukin-9-Producing T Cells
Researchers determined that T cells from mice deficient in the T helper type 17 pathway genes encoding retinoid-related orphan receptor γ and IL-23 receptor produced abundant IL-9, and found substantial growth inhibition of B16F10 melanoma in these mice. [Nat Med] Abstract | Press Release

A Specific Role for TLR1 in Protective T_H17 Immunity during Mucosal Infection
Results reveal that the route of infection is central in determining which pathways provide protective immunity. They also demonstrate that toll-like receptor 2 (TLR2) has dual immune functions in the gut and identify TLR1 as a critical innate receptor for protective intestinal T_H17 immunity. [J Exp Med]
Abstract | Press Release

Chronic Lymphocytic Leukemia and Regulatory B Cells Share IL-10 Competence and Immunosuppressive Function
Researchers found that malignant IL-10-competent chronic lymphocytic leukemia cells exhibit regulatory functions comparable to normal regulatory B cells that are competent to produce interleukin (IL)-10 that may contribute to the immunosuppression observed in patients and TCL1-transgenic mice. [Leukemia] Abstract

Cytotoxic Mechanisms Employed by Mouse T Cells to Destroy Pancreatic β-Cells
Researchers used the transfer of genetically modified diabetogenic T cells into normal, mutant, and bone marrow chimeric recipients to test the contribution of major cytotoxic mechanisms in β-cell death. [Diabetes] Abstract

Altered Phenotype of Peripheral Blood Dendritic Cells in Pediatric Type 1 Diabetes
Investigators aimed to characterize the less well-known phenotypic properties of dendritic cells in type 1 diabetes. [Diabetes Care] Abstract

Innate Immune Induction and Influenza Protection Elicited by a Response-Selective Agonist of Human C5a
Researchers found that human C5a insufflation results in the rapid induction of pulmonary cytokines and chemokines. This is followed by an influx of innate immune effector cells, including neutrophils, NK cells, and dendritic cells. [PLoS One] Full Article | Press Release

Role of Gamma-Delta T Cells in Host Response Against Staphylococcus Aureus-Induced Pneumonia
The authors concluded that accumulation of gammadelta T cells in the lungs in response to S. aureus infection is beneficial for bacteria clearance and also contributes to the tissue damage. These cells were the primary source of IL-17, which might influence the recruitment of neutrophils at the early stage of infection. [BMC Immunol] Abstract | Full Article

NOXXON Initiates Phase IIa of Anti-CXCL12/SDF-1 Spiegelmer^® NOX-A12 for Treatment of Chronic Lymphocytic Leukemia
NOXXON Pharma announced the treatment of the first cohort of three chronic lymphocytic leukemia patients in a Phase IIa clinical trial of its NOX-A12 anti-CXCL12/SDF-1 (CXC Chemokine Ligand 12/Stromal Cell-Derived Factor-1) Spiegelmer^®. [NOXXON Pharma AG] Press Release

OMT Announces New Antibody Discovery Program
Open Monoclonal Technology, Inc. (OMT) announced an antibody discovery collaboration with Merck KGaA. OMT and Merck KGaA have entered into a collaboration whereby OMT will use its OmniRats™ to generate antibodies against several targets selected by Merck KGaA. [Business Wire] Press Release

The Lupus Foundation of America and the Congressional Lupus Caucus Hold Briefing on Capitol Hill to Discuss the Public Health Consequences of Lupus
The Lupus Foundation of America convened on Capitol Hill with the Congressional Lupus Caucus and lupus community partners to share with Amercian leaders the current state of lupus research. [Lupus Foundation of America, Inc.] Press Release

National Institutes of Health (United States)

Food and Drug Administration (United States)

Center for Biologics Evaluation and Research (United States)

European Medicines Agency (European Union)

Medicines and Healthcare Products Regulatory Agency (United Kingdom)

Therapeutic Goods Administration (Australia)

NEW European Macrophage & Dendritic Cell Society (EMDS) 2012 Meeting
September 1-2, 2012
Debrecen, Hungary

NEW Cytokines 2012 10^th Joint Annual Meeting
September 11-14, 2012
Geneva, Swizerland

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