Immune Regulation News Volume 4.36 | Sep 21 2012

    0
    90

    Immune Regulation News 4.36 September 21, 2012
         In this issue: Publications | Reviews | Science News | Industry News | Policy News | Events | Jobs
    Cell Therapy News Facebook  Immune Regulation News Twitter

    TOP STORY
    BATF-JUN Is Critical for IRF4-Mediated Transcription in T Cells
    The authors showed that activator protein-1 (AP1) and interferon regulatory factor 4 (IRF4) complexes cooperatively promote transcription of the Il10 gene, which is expressed in TH17 cells and potently regulated by IL-21. These findings reveal that IRF4 can signal via complexes containing ETS or AP1 motifs depending on the cellular context, thus indicating new approaches for modulating IRF4-dependent transcription. [Nature] Abstract

    View Lectures, Tools, Protocols and Other Resources on the Human Immunology Portal (www.humanimmunologyportal.com)

    PUBLICATIONS (Ranked by impact factor of the journal)

    The Cytokines Interleukin 27 and Interferon-γ Promote Distinct Treg Cell Populations Required to Limit Infection-Induced Pathology
    Researchers found that interferon-γ and interleukin-27 (IL-27) have different roles in regulatory T (Treg) cell biology and IL-27 is a key cytokine that promotes the development of Treg cells specialized to control T helper 1 cell-mediated immunity at local sites of inflammation. [Immunity] Abstract

    Tet2 Facilitates the Derepression of Myeloid Target Genes during CEBPα-Induced Transdifferentiation of Pre-B Cells
    Researchers’ observations indicated that Tet2 helps CEBPα rapidly derepress myeloid genes during the conversion of pre-B cells into macrophages. [Mol Cell] Abstract

    Outer Membrane Vesicles of a Human Commensal Mediate Immune Regulation and Disease Protection
    Investigators revealed that Bacteroides fragilis releases polysaccharide (PSA) in outer membrane vesicles (OMVs) that induce immunomodulatory effects and prevent experimental colitis. Dendritic cells sense OMV-associated PSA through TLR2, resulting in enhanced regulatory T cells and anti-inflammatory cytokine production. [Cell Host Microbe] Abstract

    Mutant Huntingtin Fragmentation in Immune Cells Tracks Huntington’s Disease Progression
    Peripheral immune cells have been implicated in Huntington’s disease (HD) pathogenesis, but huntingtin (HTT) levels in these cells have not been quantified before. A recently described time-resolved Förster resonance energy transfer immunoassay was used to quantify mutant and total HTT protein levels in leukocytes from patients with HD. [J Clin Invest] Full Article | Press Release

    TAp73 Is Required for Macrophage-Mediated Innate Immunity and the Resolution of Inflammatory Responses
    Scientists investigated whether TAp73 contributes to innate immunity and septic shock. Their data indicated that TAp73 has a role in macrophage polarization and innate immunity, enhancing the action field of this important regulatory molecule. [Cell Death Differ] Abstract

    Cell-Intrinsic Abrogation of TGF-β Signaling Delays but Does Not Prevent Dysfunction of Self/Tumor-Specific CD8 T Cells in a Murine Model of Autochthonous Prostate Cancer
    Researchers used a model of autochthonous murine prostate cancer to evaluate the effect of cell-intrinsic abrogation of TGF-β signaling in self/tumor-specific CD8 T cells used in adoptive T cell therapy to target the tumor in situ. [J Immunol] Abstract

    B7x in the Periphery Abrogates Pancreas-Specific Damage Mediated by Self-Reactive CD8 T Cells
    Results suggest that B7x in nonlymphoid organs prevents peripheral autoimmunity partially through inhibiting proliferation of tissue-specific CD8 T cells, and that local overexpression of B7x on pancreatic β cells is sufficient to abolish CD8 T cell-induced diabetes. [J Immunol] Abstract

    Airway Epithelial Cells Condition Dendritic Cells to Express Multiple Immune Surveillance Genes
    Findings suggest that airway epithelial cell conditioning facilitates the capacity of dendritic cells to react to danger signals, to enhance leukocyte recruitment, especially of Th1 effector cells, and to interact with other immune cell populations while minimizing the risks of excessive inflammation leading to tissue damage. [PLoS One] Full Article

    Toll-Like Receptor 3 Activation Differentially Regulates Phagocytosis of Bacteria and Apoptotic Neutrophils by Mouse Peritoneal Macrophages
    Researchers found that Toll-like receptor 3 activation promotes bacterial uptake through the activation of interferon-regulating factor 3 and inhibits phagocytosis of apoptotic neutrophils through the activation of nuclear factor-κB by mouse peritoneal macrophages. [Immunol Cell Biol] Abstract

    PneumaCult™-ALI Medium for Bronchial Epithelial Cells: Watch the Video

    REVIEWS

    Metabolic Checkpoints in Activated T Cells
    The availability of specific metabolites and the pathways that process them interconnect with signaling events in the cell to influence cell cycle, differentiation, cell death and immunological function. Researchers defined ‘metabolic checkpoints’ that represent such interconnections and provide examples of how these checkpoints sense metabolic status and transduce signals to affect T lymphocyte responses. [Nat Immunol] Abstract

    T Cells Out of Control-Impaired Immune Regulation in the Inflamed Joint
    This review summarizes the latest findings on changes in effector T cell homeostasis in autoimmune disease and focuses on how mechanisms that normally regulate these cells are affected in the inflamed joints of patients with arthritis. [Nat Rev Rheumatol] Abstract

    SCIENCE NEWS
    Jennerex Presents Positive Clinical Data from Phase II Trial of JX594 in Sorafenib-Refractory Liver Cancer Patients
    Jennerex, Inc. presented Phase II clinical data of JX594 delivered first intravenously and subsequently through intra-tumoral route demonstrating safety as well as disease control and tumor responses in patients with hepatocellular carcinoma. [Press release from Jennerex, Inc. discussing research presented at the International Liver Cancer Association (ILCA) Annual Meeting, Berlin] Press Release

    INDUSTRY NEWS

    NewLink Announces an Investigator Initiated Phase II Study of Sipuleucel-T Plus Indoximod in the Treatment of Certain Men with Advanced Prostate Cancer
    NewLink Genetics announced that it will begin an investigator initiated, randomized, double blind placebo controlled Phase II study entitled “Phase II Study of sipuleucel-T (PROVENGE®) plus indoximod (D-1MT/NLG8189) in the treatment of patients with asymptomatic or minimally symptomatic metastatic hormone refractory prostate cancer.” [NewLink Genetics Corporation] Press Release

    China to Cut Prices of Cancer, Immunology and Blood Drugs
    China will cut the maximum retail prices of 95 cancer, immunology and blood-related drugs by about 17 percent to try to reduce the growing number of chronic, ageing-related diseases in the country and make healthcare more affordable. [Reuters] Press Release

    POLICY NEWS

    National Institutes of Health (United States)

    Food and Drug Administration (United States)

    Center for Biologics Evaluation and Research (United States)

    European Medicines Agency (European Union)

    Medicines and Healthcare Products Regulatory Agency (United Kingdom)

    Therapeutic Goods Administration (Australia)

    EVENTS
    NEW BIT’s 3rd Annual World Congress of Molecular & Cell Biology (CMCB 2013)
    June 14-16, 2013
    Suzhou, China

    Visit our events page to see a complete list of events in the immune regulation community.

    JOB OPPORTUNITIES

    Research Technologist – Media Development (STEMCELL Technologies, Inc.)

    Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

    Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

    Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

    Product Manager – Hematopoietic (STEMCELL Technologies, Inc.)

    Postdoctoral Position – Immunology (San Raffaele Scientific Institute)

    Postdoctoral Positions – Immunity and Inflammation (CNRS & University of Toulouse, France)

    Research Associate – Quality Assurance (University of California)

    Postdoctoral Research Fellow (Singapore Immunology Network [A*STAR])

    Recruit Top Talent: Reach more than 50,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

    Have we missed an important article or publication in Immune Regulation News? Click here to submit!

    Comments or Suggestions? Email info@connexoncreative.com with your feedback.

    Learn more about Immune Regulation News: Archives | Events | Contact Us